RetrogeneDB ID: retro_mmul_83

Retrocopy location

• Organism: Rhesus macaque (Macaca mulatta)
• Coordinates: 5:97885753..97887472(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSMMUG00000020941
• Aliases: None
• Status: KNOWN_PROTEIN_CODING

Parental gene information

• Parental gene symbol: MMU.4183
• Ensembl ID: ENSMMUG00000010489
• Aliases: None
• Description: 60 kDa heat shock protein, mitochondrial [Source:RefSeq peptide;Acc:NP_001182445]

Sequence

>retro_mmul_83
ATGCTTCGGTTACCCACAGTCTTTCGCCAGATGAGACCGGTGTCCAGAGTACTGGCTCCTCATCTCACTCGGGCTTATGC
CAAAGATGTAAAATTTGGTGCAGATGCCCGAGCCTTAATGCTTCAAGGTGTAGACCTTTTAGCCGATGCTGTGGCTGTTA
CAATGGGGCCAAAGGGAAGAACAGTGATTATTGAGCAGAGCTGGGGAAGTCCCAAAGTAACAAAAGATGGTGTGACTGTT
GCAAAGTCAATTGACTTAAAGGATAAATATAAAAACATTGGAGCTAAACTTGTTCAAGATGTTGCCAATAACACAAATGA
AGAGGCTGGGGATGGCACTACCACTGCTACTGTACTGGCACGCTCTATAGCCAAGGAAGGCTTCGAGAAGATTAGCAAAG
GTGCTAATCCCGTGGAAATCAGGAAAGGTGTGATGTTAGCTGTTGATGCTGTAATTGCTGAACTTAAAAAGCAGTCTAAA
CCTGTGACCACCCCTGAAGAAATTGCACAGGTTGCTACAATTTCTGCAAATGGAGACAAAGAAATTGGCAATATCATCTC
TGATGCAATAAAAAAGGTTGGAAGAAAGGGTGTCATCACAGTAAAGGATGGAAAAACACTGAATGATGAATTAGAAATTA
TCGAAGGCATGAAGTTTGATCGAGGCTATATTTCTCCATACTTTATTAATACATCAAAAGGTCAGAAATGTGAATTCCAG
GATGCCTATGTTCTGCTGAGTGAAAAGAAAATTTCTAGTGTCCAGTCCATTGTACCTGCTCTTGAAATTGCCAATGCTCA
CCGTAAGCCTTTGGTCATAATAGCTGAAGACGTTGATGGAGAAGCTTTAAGTACACTCGTCTTGAATAGGCTAAAGGTTG
GTCTTCAGGTTGTGGCAGTCAAGGCTCCAGGGTTTGGTGACAATAGAAAGAACCAGCTTAAAGATATGGCTATTGCTACT
GGTGGTGCAGTGTTTGGAGAAGAGGGGTTGACCATAAATGTTGAAGACGTTCAGCCTCATGACTTAGGAAAAGTTGGAGA
GGTCATTGTGACCAAAGACGATGCCATGCTCTTAAAAGGAAAAGGTGACAAGGTTAAAATTGAAAAACGTATTCAAGAAA
TCATTGAGCAGTTAGATGTCACAACTAGTGAATATGAAAAGGAAAAACTGAATGAACGGCTGGCAAAACTTTCAGATGGA
GTAGCTGTGCTGAAGGTTGGTGGGACAAGTGATGTTGAAGTGAATGAAAGGAAAGACAGAGTTACAGATGCACTTAATGC
TACAAGAGCTGCTGTTGAAGAAGGCATTGTTTTGGGAGGGGGTTGTGCCCTGCTTCGATGCATTCCAGCCTTGGACTCAT
TGACTCCAGCTAATGAAGATCAAAAAATTGGTATAGAAATTATTAAAAGAACACTCAAAATTCCAGCAATGACCATTGCT
AAGAATGCAGGTGTTGAAGGATCTTTGATAGTTGAGAAAATTATGCAGAGTTCCTCAGAAGTTGGTTATGATGCTATGGC
TGGAGATTTTGTGAATATGGTGGAAAAAGGAATTATTGTCCCAACAAAGGTTGTGAGAACTGCTTTATTGGATGCTGCTG
GTGTGGCCTCTCTGTTAACTACAGCAGAAGTTGTCGTCACAGAAATTCCTAAAGAAGAGAAGGACCCTGGAATGGGTGCA
ATGAGTGGAATGGGAGGTGGTATGGGAGGTGGCATGCCT

Alignment

ORF - retro_mmul_83 Open Reading Frame is conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 98.78 %
• Parental protein coverage: 99.83 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGS
          MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGS
Retrocopy MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGS

Parental  PKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEI
          PKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEI
Retrocopy PKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEI

Parental  RRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKASDGKTLN
          R.GVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDA.KKVGRKGVITVK..DGKTLN
Retrocopy RKGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAIKKVGRKGVITVK--DGKTLN

Parental  DELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDV
          DELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDV
Retrocopy DELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDV

Parental  DGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTINVEDVQPHDLGKVGEV
          DGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTINVEDVQPHDLGKVGEV
Retrocopy DGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTINVEDVQPHDLGKVGEV

Parental  IVTKDDAMLLKGKGDKVKIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKK
          IVTKDDAMLLKGKGDKVKIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNE.K
Retrocopy IVTKDDAMLLKGKGDKVKIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNERK

Parental  DRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGS
          DRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGS
Retrocopy DRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGS

Parental  LIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGM
          LIVEKIMQSSSEVGYDAMAGDFVNMVEKGII.PTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGM
Retrocopy LIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIVPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGM

Parental  GAMGGMGGGMGGGM
          GAM.GMGGGMGGGM
Retrocopy GAMSGMGGGMGGGM

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	0.00 RPM	40.34 RPM
SRP007412_brain_prefrontal_cortex	2.38 RPM	66.16 RPM
SRP007412_cerebellum	0.26 RPM	39.84 RPM
SRP007412_heart	0.35 RPM	65.72 RPM
SRP007412_kidney	0.23 RPM	132.51 RPM
SRP007412_liver	2.57 RPM	89.30 RPM
SRP007412_testis	0.26 RPM	21.37 RPM

ChIP-Seq

Macaca mulatta was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_mmul_83 retrocopy.

TSS

Macaca mulatta was not studied using FANTOM5 data.

Lab

retro_mmul_83 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmul_83 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 25 parental genes, and 94 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000013770	1 retrocopy	retro_amel_771,
Bos taurus	ENSBTAG00000012586	1 retrocopy	retro_btau_988,
Canis familiaris	ENSCAFG00000010865	4 retrocopies	retro_cfam_1185, retro_cfam_1620, retro_cfam_2165, retro_cfam_614,
Choloepus hoffmanni	ENSCHOG00000007401	5 retrocopies	retro_chof_1105, retro_chof_1300, retro_chof_1822, retro_chof_2000, retro_chof_2397,
Callithrix jacchus	ENSCJAG00000003990	6 retrocopies	retro_cjac_1516, retro_cjac_1534, retro_cjac_1975, retro_cjac_3172, retro_cjac_3400, retro_cjac_4096,
Dasypus novemcinctus	ENSDNOG00000013226	3 retrocopies	retro_dnov_1990, retro_dnov_2113, retro_dnov_2512,
Echinops telfairi	ENSETEG00000009184	4 retrocopies	retro_etel_1440, retro_etel_426, retro_etel_885, retro_etel_925,
Homo sapiens	ENSG00000144381	7 retrocopies	retro_hsap_1006, retro_hsap_2770, retro_hsap_2987, retro_hsap_3151, retro_hsap_3494, retro_hsap_3930, retro_hsap_4018,
Gorilla gorilla	ENSGGOG00000008267	6 retrocopies	retro_ggor_1927, retro_ggor_2069, retro_ggor_2361, retro_ggor_2698, retro_ggor_800, retro_ggor_985,
Loxodonta africana	ENSLAFG00000000053	1 retrocopy	retro_lafr_476,
Macropus eugenii	ENSMEUG00000011987	2 retrocopies	retro_meug_1688, retro_meug_224,
Myotis lucifugus	ENSMLUG00000000871	4 retrocopies	retro_mluc_1458, retro_mluc_2280, retro_mluc_2348, retro_mluc_601,
Macaca mulatta	ENSMMUG00000010489	1 retrocopy	retro_mmul_83 ,
Monodelphis domestica	ENSMODG00000012289	3 retrocopies	retro_mdom_427, retro_mdom_493, retro_mdom_756,
Mustela putorius furo	ENSMPUG00000007818	3 retrocopies	retro_mputfur_1118, retro_mputfur_245, retro_mputfur_434,
Mus musculus	ENSMUSG00000025980	5 retrocopies	retro_mmus_1225, retro_mmus_2494, retro_mmus_3206, retro_mmus_439, retro_mmus_706,
Nomascus leucogenys	ENSNLEG00000006874	7 retrocopies	retro_nleu_1349, retro_nleu_2238, retro_nleu_229, retro_nleu_657, retro_nleu_675, retro_nleu_691, retro_nleu_787,
Otolemur garnettii	ENSOGAG00000034053	5 retrocopies	retro_ogar_2335, retro_ogar_2420, retro_ogar_2740, retro_ogar_3221, retro_ogar_3497,
Pongo abelii	ENSPPYG00000013046	5 retrocopies	retro_pabe_2040, retro_pabe_2244, retro_pabe_2476, retro_pabe_2887, retro_pabe_848,
Pteropus vampyrus	ENSPVAG00000008306	1 retrocopy	retro_pvam_250,
Rattus norvegicus	ENSRNOG00000014525	9 retrocopies	retro_rnor_1000, retro_rnor_1006, retro_rnor_1308, retro_rnor_1578, retro_rnor_1585, retro_rnor_2812, retro_rnor_2835, retro_rnor_596, retro_rnor_905,
Ictidomys tridecemlineatus	ENSSTOG00000028470	1 retrocopy	retro_itri_224,
Tarsius syrichta	ENSTSYG00000000513	6 retrocopies	retro_tsyr_1091, retro_tsyr_1181, retro_tsyr_1445, retro_tsyr_2082, retro_tsyr_395, retro_tsyr_804,
Tursiops truncatus	ENSTTRG00000003417	3 retrocopies	retro_ttru_1661, retro_ttru_1798, retro_ttru_951,
Xenopus tropicalis	ENSXETG00000007509	1 retrocopy	retro_xtro_63,