RetrogeneDB ID: retro_mmul_2632

Retrocopy location

• Organism: Rhesus macaque (Macaca mulatta)
• Coordinates: X:119324040..119325528(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: MMU.5357
• Ensembl ID: ENSMMUG00000004696
• Aliases: None
• Description: heat shock cognate 71 kDa protein [Source:RefSeq peptide;Acc:NP_001248586]

Sequence

>retro_mmul_2632
ACTCAGCATCAGGCTAACAAAGATGCTGGAACTATTGCTGGTCTCAATGTACTTAGAATTATTAATGAACCAACTGCTGA
TGCTATTGCTTACAGCTTAGACAAAAAGGTTAGAGCAGAAAGAAACATGCTGATTTTTGACCTGGGAGGCGGCACTTTTG
ATGTGTCAATCCTCAATACTGAGGATGGAATCTTTGAGGCCAAATCTACAGCCAGAGACACCCACTTGGGTGAAGAAGAT
TTTGACAACCGAATGGTCTACCGTTTTATTGCTGAGTTCAAGCACAAGCACAAGCCCAAGAAGGACATCAGTGAGAAAAA
GAGAGCTGTAAGACGCCTCCGTACTGCTTGTGAACGTGCTAAGAGTACTCTCTCTTCCAGCACCCATGCCAGTATTGAGA
TAGATTTTCTCTCTGAAGGAATCGACTTCTATACCTCCAATACCCATGCCTGATTTGAAGAATTGAATGCTGACCTGTTC
CATAGAACCCTGGACCTGGCAGAGAAAGCCCTTCGAGATGCCAAACTAGACAAGTCACAGATTCACAATATTGTCCTGGT
TGGTATTTCTACTCATATCCCCAAGATTCAGAATCTTCTCCAAGACTTCTCCCATGAAAAATAACTGAATAAGAGCATCA
ACCCTGATGAAGCTGTTGCTTATGGTGCAGCTGTCCAGGCAGCCATCCTGTCTGGAGACAAGTCTGAAAATGTTCAAGAT
TTGCTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTGAAACTGCTGGTGGAGTCATGACCGACCTCATCAAACATAC
TACTACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTCTGACAACCAGCCTGGTGTGCTTATTCAGGTTTATG
AAGGTGAGCATACCATGACCAAGGATGACAACCTGCTTGACAAGTTTGAACTCACAGGCATACCTCCTGCACCCTGAGGT
GTTCCTCAGATTGAAGTCACTTTTGACACTGATGCCAATGGCATCTTCAATGTCTCTGCTGTGGACAAGAGTACAAGAAA
AAAGAATAAGATTACTATCACTAACGACAAGGGCCATTTGAGCAAGGAAGACATTGAACATATGGTCCAGGAAGCTGAGA
AGTACAAAGTTGAAGATAAGAAGCAGAGGGACGAAGTGTCATCCAAGAATTCACTTGACTCCTGTGAATTCAACATGAAA
GCAACTCTCAAAGATGAGAAAATTCAAGGCAAGATTAACGATGAAGACAAACAGAAGATTCTGCACGAGTATAATGAAAT
TATCAACTGGCTCAATAAGAATCAGACTGCTGAGAAGGAAGAATTTGAACATCAGCAGAAACAGCTGGAGAAAGTCTGCA
ACCCCATCATTACCAAGCTGTACTTGAGGGCAGGAGGCAAGCCAGGAGGAATGCCTGGGGGATTTCCTGGTGGTGGAGCT
CCTCCCTCTGGTGGTGCTTCATCAGGGCTCACCATTGAAGAGGTTGAT

Alignment

ORF - retro_mmul_2632 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 86.09 %
• Parental protein coverage: 76.47 %
• Number of stop codons detected: 3
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  SQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKST
          .Q.QA.KDAGTIAGLNVLRIINEPTA.AIAY.LDKKV.AERN.LIFDLGGGTFDVSIL..EDGIFE.KST
Retrocopy TQHQANKDAGTIAGLNVLRIINEPTADAIAYSLDKKVRAERNMLIFDLGGGTFDVSILNTEDGIFEAKST

Parental  AGDTHLGGEDFDNRMVNHFIAEFKRKHK--KDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEG
          A.DTHLG.EDFDNRMV..FIAEFK.KHK..KDISE.KRAVRRLRTACERAK.TLSSST.ASIEID.L.EG
Retrocopy ARDTHLGEEDFDNRMVYRFIAEFKHKHKPKKDISEKKRAVRRLRTACERAKSTLSSSTHASIEIDFLSEG

Parental  IDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELN
          IDFYTS.T.A.FEELNADLF..TLD..EKALRDAKLDKSQIH.IVLVG.ST.IPKIQ.LLQDF...K.LN
Retrocopy IDFYTSNTHA*FEELNADLFHRTLDLAEKALRDAKLDKSQIHNIVLVGISTHIPKIQNLLQDFSHEK*LN

Parental  KSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTT
          KSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMT.LIK..TTIPTKQTQTFTT
Retrocopy KSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTDLIKHTTTIPTKQTQTFTT

Parental  YSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENK
          YSDNQPGVLIQVYEGE..MTKD.NLL.KFELTGIPPAP.GVPQIEVTFD.DANGI.NVSAVDKST.K.NK
Retrocopy YSDNQPGVLIQVYEGEHTMTKDDNLLDKFELTGIPPAP*GVPQIEVTFDTDANGIFNVSAVDKSTRKKNK

Parental  ITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKI
          ITITNDKG.LSKEDIE.MVQEAEKYK.ED.KQRD.VSSKNSL.S..FNMKAT..DEK.QGKINDEDKQKI
Retrocopy ITITNDKGHLSKEDIEHMVQEAEKYKVEDKKQRDEVSSKNSLDSCEFNMKATLKDEKIQGKINDEDKQKI

Parental  LDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGP
          L...NEIINWL.KNQTAEKEEFEHQQK.LEKVCNPIITKLY..AGG.PGGMPGGFPGGGAPPSGGASSG.
Retrocopy LHEYNEIINWLNKNQTAEKEEFEHQQKQLEKVCNPIITKLYLRAGGKPGGMPGGFPGGGAPPSGGASSGL

Parental  TIEEVD
          TIEEVD
Retrocopy TIEEVD

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	0.11 RPM	1399.06 RPM
SRP007412_brain_prefrontal_cortex	0.32 RPM	1177.02 RPM
SRP007412_cerebellum	0.13 RPM	1090.15 RPM
SRP007412_heart	0.00 RPM	748.79 RPM
SRP007412_kidney	0.00 RPM	1404.90 RPM
SRP007412_liver	0.04 RPM	789.22 RPM
SRP007412_testis	0.00 RPM	185.00 RPM

ChIP-Seq

Macaca mulatta was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_mmul_2632 retrocopy.

TSS

Macaca mulatta was not studied using FANTOM5 data.

Lab

retro_mmul_2632 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmul_2632 has 4 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_4896
Pan troglodytes	retro_ptro_3264
Gorilla gorilla	retro_ggor_3057
Pongo abelii	retro_pabe_3808

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Parental genes homology:

Parental genes homology involve 27 parental genes, and 74 retrocopies.

Species	Parental gene accession	Retrocopies number
Anolis carolinensis	ENSACAG00000004884	2 retrocopies	retro_acar_21, retro_acar_6,
Ailuropoda melanoleuca	ENSAMEG00000008425	1 retrocopy	retro_amel_126,
Anas platyrhynchos	ENSAPLG00000010667	1 retrocopy	retro_apla_6,
Bos taurus	ENSBTAG00000013162	1 retrocopy	retro_btau_354,
Canis familiaris	ENSCAFG00000011666	3 retrocopies	retro_cfam_140, retro_cfam_191, retro_cfam_509,
Ciona intestinalis	ENSCING00000009665	1 retrocopy	retro_cint_12,
Cavia porcellus	ENSCPOG00000004169	3 retrocopies	retro_cpor_1072, retro_cpor_619, retro_cpor_938,
Ciona savignyi	ENSCSAVG00000008588	1 retrocopy	retro_csav_3,
Dipodomys ordii	ENSDORG00000015467	1 retrocopy	retro_dord_16,
Echinops telfairi	ENSETEG00000010996	1 retrocopy	retro_etel_43,
Ficedula albicollis	ENSFALG00000005812	1 retrocopy	retro_falb_18,
Felis catus	ENSFCAG00000001132	6 retrocopies	retro_fcat_132, retro_fcat_1331, retro_fcat_1571, retro_fcat_1775, retro_fcat_556, retro_fcat_79,
Homo sapiens	ENSG00000109971	8 retrocopies	retro_hsap_2384, retro_hsap_2710, retro_hsap_2758, retro_hsap_340, retro_hsap_3698, retro_hsap_4892, retro_hsap_4896, retro_hsap_68,
Gallus gallus	ENSGALG00000006512	1 retrocopy	retro_ggal_8,
Loxodonta africana	ENSLAFG00000030312	4 retrocopies	retro_lafr_1218, retro_lafr_391, retro_lafr_790, retro_lafr_797,
Meleagris gallopavo	ENSMGAG00000001929	1 retrocopy	retro_mgal_9,
Myotis lucifugus	ENSMLUG00000004834	3 retrocopies	retro_mluc_1800, retro_mluc_2300, retro_mluc_777,
Macaca mulatta	ENSMMUG00000004696	7 retrocopies	retro_mmul_1536, retro_mmul_2188, retro_mmul_2628, retro_mmul_2632 , retro_mmul_580, retro_mmul_778, retro_mmul_963,
Monodelphis domestica	ENSMODG00000012958	2 retrocopies	retro_mdom_127, retro_mdom_99,
Mustela putorius furo	ENSMPUG00000005810	9 retrocopies	retro_mputfur_1048, retro_mputfur_1056, retro_mputfur_1144, retro_mputfur_131, retro_mputfur_188, retro_mputfur_309, retro_mputfur_627, retro_mputfur_694, retro_mputfur_958,
Oreochromis niloticus	ENSONIG00000004759	1 retrocopy	retro_onil_2,
Pelodiscus sinensis	ENSPSIG00000012450	2 retrocopies	retro_psin_17, retro_psin_5,
Pan troglodytes	ENSPTRG00000004404	5 retrocopies	retro_ptro_1743, retro_ptro_2507, retro_ptro_272, retro_ptro_3259, retro_ptro_3264,
Taeniopygia guttata	ENSTGUG00000000491	1 retrocopy	retro_tgut_7,
Takifugu rubripes	ENSTRUG00000005265	1 retrocopy	retro_trub_30,
Tursiops truncatus	ENSTTRG00000011139	6 retrocopies	retro_ttru_1507, retro_ttru_1650, retro_ttru_1696, retro_ttru_35, retro_ttru_741, retro_ttru_808,
Xiphophorus maculatus	ENSXMAG00000001602	1 retrocopy	retro_xmac_20,