RetrogeneDB ID: retro_fcat_1331

Retrocopy location

• Organism: Cat (Felis catus)
• Coordinates: C2:38749757..38751521(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: HSPA8
• Ensembl ID: ENSFCAG00000001132
• Aliases: None
• Description: heat shock 70kDa protein 8 [Source:HGNC Symbol;Acc:5241]

Sequence

>retro_fcat_1331
GATGCTGCAAAGAATCAAGTTGCAATGAATCCCAACACAGTTTTTGATGCCAAACATCTGATTGGAGGTAGATTCGACAA
TGCTGTCATCCAATCTGATATGAAGCATTGGCCCTTCATGGTGGTGAACAATGCTGGCAGGCCCAAGGTCCAAGTAGAAT
ACGAGGAAGAGACCAAAAGTTTCTATCCAGAGGAGGTGTCTTCTATGGTTTTGACAAAGATGAAGGAAATCACAGAGGCT
TACCTTGGGAAGACTGTTACCAATGCTGTAGTCACAGCACCTGCCTATTTTAACAAGTCTCAGCATTAGGCTACCAAACA
TGCTGGAAATATTGCTGGTCTTAATGTACTACGAATCATCAGTGAGCCAACTGCTGCTGCTATTGCTTATGGCTTAGACA
AAAAGGTTGGAGCTGAAAGGAATGTGTTGATCTTTGACTTGGGAGGTGGCACTTTTGATGTGTCAATCCTCACTATTGAA
GATGGGATCTTTGAGGTCAAATCTGCTGGAGACACCCACTTAGGTGGAGAAGACTTTCACAACCAAATGGTAAACCATTT
TATTGCAGAGTTCAAATGAAAACATAAGCAGGACATCAGTGAGAACAAGCGGGCAGCACGTTGCCTCCATACTGCTTGCG
AGCGCACCAAGCGCACACTTTCTTCCAGCACTCAGGCCAGTATTGAGGTTGATTCTCTATATGAAGGAATGGACTTTTAT
ACTTCTATTACTCGTGCCTGGTTTGAAGAATTAAATGCTGACCTGTTCCGTGGCATCCTGGACCCTGTAGAGAAAGCCCT
TCGGGATGCCAAGTTTGACAAGTCTCAGATCCACGATATTGTCTTGATGGGTGGTTCTGCAAGTATCCCCAAGATTCAGA
AACTTCTACAAGACTTTTTCAATGGGAAGGAACTGAATAAGAGCATCAACCCTGATGAGGCTGTCGCTTATGGTGCAGCT
GTCCAGGCAGCCATCCTTTCTGGAGACAAATCTGAAAATACTCAAGATTTGCTGCTGTTGGATGTCACTCTTCTTTCTCT
TCGCATTGAAACTGCTGGTGGAGTCATGACTGTTCTCATCAAGCACAATACTACCATTCCTACCAAACATACCCAAACCT
TCACTACCTACTCTGACAACCAGCCTGGTGTGCTCATTCAGGTTTATGAAGGTGAGCGTGCCATGACCAAGGATAACAAC
CTACTTGGCAAGTTTGAACTCACAGGCATACCTCCTGCCCCCCGGGGTGTTCCTCAGATTGGGGTTACCTTTGATATTGA
TGCTAATGGCATTCTCAGTGTCTCTGCTGTGGATAAGAGTACAGGAAAAGAGAACAAGATCACCATCGCAAATGACAAAG
GTCGCATGAGCCAGGAAGACATTGAGCACATGGTCCAGGAAGCTGAGAAGCACAAAGCTGAAGATGAGAAGCAGCGAGAC
AAGGTGTCCTTCAAGCATTCAGTTGAATCTTATGCATTCAACATGAAAGCAGCTGTTGAAGACAAAAAGCTTCAGGGTAA
AATCAGCGATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATCATCAACTGGCTGGATAAGAACCAGACTGCAG
TAAAAGAAGAATTTGAGCATCGGCAGAAAGAGCTGGAGAAGGTCTGCAATCCCGTCATTACGAAGCTGTACCAGAGTGCA
GGAGGCATGCCTGGAGGCTTCCCTGGTGGTGGAGCTCCCCCATCTGGAGGTGCCTCCTCTGGGCCCACCATTGAAGAGGT
TGAT

Alignment

ORF - retro_fcat_1331 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 90.24 %
• Parental protein coverage: 91.95 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  DAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSM
          DAAKNQVAMNP.NTVFDAK.LIG.RFD.AV.QSDMKHWPFMVVN.AGRPKVQVEY..ETKSFYPEEVSSM
Retrocopy DAAKNQVAMNP-NTVFDAKHLIGGRFDNAVIQSDMKHWPFMVVNNAGRPKVQVEYEEETKSFYPEEVSSM

Parental  VLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAE
          VLTKMKEI.EAYLGKTVTNAVVT.PAYFN.SQ..ATK.AG.IAGLNVLRII.EPTAAAIAYGLDKKVGAE
Retrocopy VLTKMKEITEAYLGKTVTNAVVTAPAYFNKSQH*ATKHAGNIAGLNVLRIISEPTAAAIAYGLDKKVGAE

Parental  RNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRR
          RNVLIFDLGGGTFDVSILTIEDGIFEVKS.AGDTHLGGEDF.N.MVNHFIAEFK.KHK.DISENKRA.R.
Retrocopy RNVLIFDLGGGTFDVSILTIEDGIFEVKS-AGDTHLGGEDFHNQMVNHFIAEFK*KHKQDISENKRAARC

Parental  LRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIH
          L.TACER.KRTLSSSTQASIE.DSLYEG.DFYTSITRA.FEELNADLFRG.LDPVEKALRDAK.DKSQIH
Retrocopy LHTACERTKRTLSSSTQASIEVDSLYEGMDFYTSITRAWFEELNADLFRGILDPVEKALRDAKFDKSQIH

Parental  DIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLG
          DIVL.GGS..IPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSEN.QDLLLLDVT.LSL.
Retrocopy DIVLMGGSASIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENTQDLLLLDVTLLSLR

Parental  IETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVP
          IETAGGVMTVLIK.NTTIPTK.TQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVP
Retrocopy IETAGGVMTVLIKHNTTIPTKHTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVP

Parental  QIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSL
          QI.VTFDIDANGIL.VSAVDKSTGKENKITI.NDKGR.S.EDIE.MVQEAEK.KAEDEKQRDKVS.K.S.
Retrocopy QIGVTFDIDANGILSVSAVDKSTGKENKITIANDKGRMSQEDIEHMVQEAEKHKAEDEKQRDKVSFKHSV

Parental  ESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQ
          ESYAFNMKA.VED.KLQGKI.DEDKQKILDKCNEIINWLDKNQTA.KEEFEH.QKELEKVCNP.ITKLYQ
Retrocopy ESYAFNMKAAVEDKKLQGKISDEDKQKILDKCNEIINWLDKNQTAVKEEFEHRQKELEKVCNPVITKLYQ

Parental  SAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
          SAGGMPGG....FPGGGAPPSGGASSGPTIEEVD
Retrocopy SAGGMPGG----FPGGGAPPSGGASSGPTIEEVD

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP017611_brain	3.33 RPM	1350.76 RPM
SRP017611_kidney	2.47 RPM	1074.48 RPM
SRP017611_liver	1.31 RPM	606.03 RPM

ChIP-Seq

Felis catus was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_fcat_1331 retrocopy.

TSS

Felis catus was not studied using FANTOM5 data.

Lab

retro_fcat_1331 was not experimentally validated.

Homology

Retrocopy orthology:

Felis catus does not belong to any of the species groups (eutheria, teleost or neognath), studied for retrocopy-based homology. For more information about studied groups, please go to help section.

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Parental genes homology:

Parental genes homology involve 32 parental genes, and 108 retrocopies.

Species	Parental gene accession	Retrocopies number
Anolis carolinensis	ENSACAG00000004884	2 retrocopies	retro_acar_21, retro_acar_6,
Ailuropoda melanoleuca	ENSAMEG00000008425	1 retrocopy	retro_amel_126,
Anas platyrhynchos	ENSAPLG00000010667	1 retrocopy	retro_apla_6,
Bos taurus	ENSBTAG00000013162	1 retrocopy	retro_btau_354,
Canis familiaris	ENSCAFG00000011666	3 retrocopies	retro_cfam_140, retro_cfam_191, retro_cfam_509,
Ciona intestinalis	ENSCING00000009665	1 retrocopy	retro_cint_12,
Callithrix jacchus	ENSCJAG00000007648	5 retrocopies	retro_cjac_2388, retro_cjac_3306, retro_cjac_3898, retro_cjac_4057, retro_cjac_721,
Cavia porcellus	ENSCPOG00000004169	3 retrocopies	retro_cpor_1072, retro_cpor_619, retro_cpor_938,
Ciona savignyi	ENSCSAVG00000008588	1 retrocopy	retro_csav_3,
Dipodomys ordii	ENSDORG00000015467	1 retrocopy	retro_dord_16,
Echinops telfairi	ENSETEG00000010996	1 retrocopy	retro_etel_43,
Ficedula albicollis	ENSFALG00000005812	1 retrocopy	retro_falb_18,
Felis catus	ENSFCAG00000001132	6 retrocopies	retro_fcat_132, retro_fcat_1331 , retro_fcat_1571, retro_fcat_1775, retro_fcat_556, retro_fcat_79,
Homo sapiens	ENSG00000109971	8 retrocopies	retro_hsap_2384, retro_hsap_2710, retro_hsap_2758, retro_hsap_340, retro_hsap_3698, retro_hsap_4892, retro_hsap_4896, retro_hsap_68,
Gallus gallus	ENSGALG00000006512	1 retrocopy	retro_ggal_8,
Gorilla gorilla	ENSGGOG00000008381	8 retrocopies	retro_ggor_1053, retro_ggor_1810, retro_ggor_1888, retro_ggor_1918, retro_ggor_2501, retro_ggor_3054, retro_ggor_3057, retro_ggor_360,
Loxodonta africana	ENSLAFG00000030312	4 retrocopies	retro_lafr_1218, retro_lafr_391, retro_lafr_790, retro_lafr_797,
Meleagris gallopavo	ENSMGAG00000001929	1 retrocopy	retro_mgal_9,
Myotis lucifugus	ENSMLUG00000004834	3 retrocopies	retro_mluc_1800, retro_mluc_2300, retro_mluc_777,
Macaca mulatta	ENSMMUG00000004696	7 retrocopies	retro_mmul_1536, retro_mmul_2188, retro_mmul_2628, retro_mmul_2632, retro_mmul_580, retro_mmul_778, retro_mmul_963,
Monodelphis domestica	ENSMODG00000012958	2 retrocopies	retro_mdom_127, retro_mdom_99,
Mustela putorius furo	ENSMPUG00000005810	9 retrocopies	retro_mputfur_1048, retro_mputfur_1056, retro_mputfur_1144, retro_mputfur_131, retro_mputfur_188, retro_mputfur_309, retro_mputfur_627, retro_mputfur_694, retro_mputfur_958,
Mus musculus	ENSMUSG00000015656	8 retrocopies	retro_mmus_2244, retro_mmus_2584, retro_mmus_26, retro_mmus_2621, retro_mmus_2840, retro_mmus_316, retro_mmus_351, retro_mmus_620,
Oryctolagus cuniculus	ENSOCUG00000015533	4 retrocopies	retro_ocun_1308, retro_ocun_53, retro_ocun_584, retro_ocun_753,
Oreochromis niloticus	ENSONIG00000004759	1 retrocopy	retro_onil_2,
Pongo abelii	ENSPPYG00000003987	9 retrocopies	retro_pabe_183, retro_pabe_2193, retro_pabe_2254, retro_pabe_2260, retro_pabe_2261, retro_pabe_3153, retro_pabe_355, retro_pabe_3804, retro_pabe_3808,
Pelodiscus sinensis	ENSPSIG00000012450	2 retrocopies	retro_psin_17, retro_psin_5,
Pan troglodytes	ENSPTRG00000004404	5 retrocopies	retro_ptro_1743, retro_ptro_2507, retro_ptro_272, retro_ptro_3259, retro_ptro_3264,
Taeniopygia guttata	ENSTGUG00000000491	1 retrocopy	retro_tgut_7,
Takifugu rubripes	ENSTRUG00000005265	1 retrocopy	retro_trub_30,
Tursiops truncatus	ENSTTRG00000011139	6 retrocopies	retro_ttru_1507, retro_ttru_1650, retro_ttru_1696, retro_ttru_35, retro_ttru_741, retro_ttru_808,
Xiphophorus maculatus	ENSXMAG00000001602	1 retrocopy	retro_xmac_20,