RetrogeneDB ID: retro_cfam_492

Retrocopy location

• Organism: Dog (Canis familiaris)
• Coordinates: 12:42854488..42854992(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: PRDX6
• Ensembl ID: ENSCAFG00000014579
• Aliases: None
• Description: peroxiredoxin 6 [Source:HGNC Symbol;Acc:16753]

Sequence

>retro_cfam_492
AGAGCAGCAAATCTAGCACTACAATTTAGCAAGAGGAATGTAAAAGATGATTGCTCTTTTAATAGACCATGCTGAAGACC
ATCCTCCTGGAGTAAGGGTATCACTGCTTACAATGGTGAGAAGTCCACAGAAATGTTACCTTTTCTAATCATTGATGATA
AGAATCAAGAGTTTACAATCTTGTTGGGCATTCTGGGCACAGCAGAGAAGAATATACAGGGCATTCCTATGACAGCTTGT
GTGATGTTTATTTTTGGTCCTGATAAGAAATTGAAGCTGTCATCCTCTATTTAGCTACCACTGGCAGAAACTTTGATGAA
ATTCTCAAAGTAGTTATTTCTTTCAAGCTGACATTGGAAAAGACAGTTGACACCCTGGCTAATTGGAGGAATGAAGACAG
AGTGATGGGCCTTCCAATCATCTCTAAAGACATAACCAAAAAATTTCCCTAAAGGAGTCTTTACCGAGGTGCTCCCATCT
GGCAAAAAAGACCTCCGCTATACT

Alignment

ORF - retro_cfam_492 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 64.16 %
• Parental protein coverage: 76.47 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 4

Retrocopy - Parental Gene Alignment:

Parental  RAAKLAPEFAKKNVK-MIALSVDSVEDH-LAWSKDINAYNGQEPTETLPFPIIDDKNRDLAILLGMLDPA
          RAA.LA..F.K.NVK.MIAL..D..EDH...WSK.I.AYNG...TE.LPF.IIDDKN....ILLG.L..A
Retrocopy RAANLALQFSKRNVK>MIALLIDHAEDH<SSWSKGITAYNGEKSTEMLPFLIIDDKNQEFTILLGILGTA

Parental  EKDEKGMPVTARVVFIFGPDKKLKLS-ILYPATTGRNFDEILRVITSLQLTAEKRVATPVDWKDGDSVMV
          EK...G.P.TA.V.FIFGPDKKLKLS.ILY.ATTGRNFDEIL.V..S..LT.EK.V.T...W...D.VM.
Retrocopy EKNIQGIPMTACVMFIFGPDKKLKLS<ILYLATTGRNFDEILKVVISFKLTLEKTVDTLANWRNEDRVMG

Parental  LPTIPEDEAKKLFP-KGVFTKELPSGKKYLRYT
          LP.I..D..KK.FP.KGVFT..LPSGKK.LRYT
Retrocopy LPIISKDITKK-FP>KGVFTEVLPSGKKDLRYT

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP012049_cerebellum	0.00 RPM	48.72 RPM
SRP017611_brain	0.00 RPM	56.29 RPM
SRP017611_kidney	0.00 RPM	577.43 RPM
SRP017611_liver	0.00 RPM	258.73 RPM

ChIP-Seq

Canis familiaris was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_cfam_492 retrocopy.

TSS

Canis familiaris was not studied using FANTOM5 data.

Lab

retro_cfam_492 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_cfam_492 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Equus caballus	retro_ecab_215

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Parental genes homology:

Parental genes homology involve 21 parental genes, and 40 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000015560	1 retrocopy	retro_amel_493,
Bos taurus	ENSBTAG00000004855	2 retrocopies	retro_btau_1325, retro_btau_1477,
Canis familiaris	ENSCAFG00000014579	1 retrocopy	retro_cfam_492 ,
Choloepus hoffmanni	ENSCHOG00000011367	6 retrocopies	retro_chof_1143, retro_chof_1361, retro_chof_1364, retro_chof_225, retro_chof_2483, retro_chof_2598,
Callithrix jacchus	ENSCJAG00000009355	6 retrocopies	retro_cjac_1903, retro_cjac_2188, retro_cjac_3008, retro_cjac_3239, retro_cjac_3830, retro_cjac_4000,
Cavia porcellus	ENSCPOG00000011091	1 retrocopy	retro_cpor_623,
Equus caballus	ENSECAG00000022468	1 retrocopy	retro_ecab_215,
Erinaceus europaeus	ENSEEUG00000004040	1 retrocopy	retro_eeur_475,
Homo sapiens	ENSG00000117592	2 retrocopies	retro_hsap_1046, retro_hsap_3017,
Gorilla gorilla	ENSGGOG00000026357	1 retrocopy	retro_ggor_2086,
Macaca mulatta	ENSMMUG00000008776	1 retrocopy	retro_mmul_1928,
Monodelphis domestica	ENSMODG00000004032	2 retrocopies	retro_mdom_462, retro_mdom_661,
Mustela putorius furo	ENSMPUG00000004648	1 retrocopy	retro_mputfur_1328,
Mus musculus	ENSMUSG00000026701	2 retrocopies	retro_mmus_181, retro_mmus_2334,
Nomascus leucogenys	ENSNLEG00000015278	2 retrocopies	retro_nleu_2244, retro_nleu_917,
Pan troglodytes	ENSPTRG00000042455	1 retrocopy	retro_ptro_70,
Pteropus vampyrus	ENSPVAG00000002596	2 retrocopies	retro_pvam_1389, retro_pvam_805,
Rattus norvegicus	ENSRNOG00000002896	3 retrocopies	retro_rnor_2084, retro_rnor_754, retro_rnor_806,
Sarcophilus harrisii	ENSSHAG00000003248	1 retrocopy	retro_shar_478,
Tarsius syrichta	ENSTSYG00000010073	2 retrocopies	retro_tsyr_1395, retro_tsyr_193,
Tursiops truncatus	ENSTTRG00000008478	1 retrocopy	retro_ttru_1274,