RetrogeneDB ID: retro_ptro_1759

Retrocopy location

• Organism: Chimpanzee (Pan troglodytes)
• Coordinates: 3:17588344..17588588(+)
• Located in intron of: ENSPTRG00000014676

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: C8orf59
• Ensembl ID: ENSPTRG00000020385
• Aliases: None
• Description: chromosome 8 open reading frame 59 [Source:HGNC Symbol;Acc:32235]

Sequence

>retro_ptro_1759
AGAGGGAAGAAGTCCAGCAATGTATTTCACATATCCAGTTAAAAAAACTTTAGGGTTCAAAACAAAGCAAAACCAATTAC
CACTAATCTTGTAAACAATTTAAACACTGAAAAAGTTAGCAGAGTGAATAAAGTTTTTATACATATACAGAAAAAAACTT
GCTCATTTCTCAAAAGGCCTTTCCCTTGAACCTCTGCAGAAACAGCTGATTCCTCAGCAGCATCATGAGAACAAACCAGT
TAAT

Alignment

ORF - retro_ptro_1759 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 67.86 %
• Parental protein coverage: 83. %
• Number of stop codons detected: 1
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  RGPKSRNVFHIASQKNFKAKNKAKPVTTNLKKINIMNEEKVNRVNKAFVNVQKE-LAHFAKSISLEPLQK
          RG.KS.NVFHI.S.KNF...NKAKP.TTNL...N..N.EKV.RVNK.F...QK..LAHF.K..SLEPLQK
Retrocopy RGKKSSNVFHISS*KNFRVQNKAKPITTNL--VNNLNTEKVSRVNKVFIHIQKK>LAHFSKGLSLEPLQK

Parental  ELIPQQRHESKPVN
          .LIPQQ.HE.KPVN
Retrocopy QLIPQQHHENKPVN

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.02 RPM	9.31 RPM
SRP007412_cerebellum	0.00 RPM	4.80 RPM
SRP007412_heart	0.06 RPM	11.92 RPM
SRP007412_kidney	0.00 RPM	14.46 RPM
SRP007412_liver	0.00 RPM	9.20 RPM
SRP007412_testis	0.00 RPM	8.33 RPM

ChIP-Seq

Pan troglodytes was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_ptro_1759 retrocopy.

TSS

Pan troglodytes was not studied using FANTOM5 data.

Lab

retro_ptro_1759 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ptro_1759 has 5 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_2609
Gorilla gorilla	retro_ggor_1828
Pongo abelii	retro_pabe_2345
Macaca mulatta	retro_mmul_1475
Callithrix jacchus	retro_cjac_1556

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Parental genes homology:

Parental genes homology involve 15 parental genes, and 46 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000002409	2 retrocopies	retro_amel_1005, retro_amel_1049,
Bos taurus	ENSBTAG00000032227	2 retrocopies	retro_btau_158, retro_btau_7,
Callithrix jacchus	ENSCJAG00000000379	5 retrocopies	retro_cjac_1214, retro_cjac_1556, retro_cjac_1984, retro_cjac_2448, retro_cjac_2762,
Cavia porcellus	ENSCPOG00000021965	5 retrocopies	retro_cpor_201, retro_cpor_554, retro_cpor_765, retro_cpor_841, retro_cpor_962,
Felis catus	ENSFCAG00000026366	1 retrocopy	retro_fcat_450,
Homo sapiens	ENSG00000176731	4 retrocopies	retro_hsap_2609, retro_hsap_3163, retro_hsap_3606, retro_hsap_52,
Gorilla gorilla	ENSGGOG00000027464	4 retrocopies	retro_ggor_1218, retro_ggor_1353, retro_ggor_1828, retro_ggor_2433,
Loxodonta africana	ENSLAFG00000032612	4 retrocopies	retro_lafr_1083, retro_lafr_1242, retro_lafr_911, retro_lafr_944,
Myotis lucifugus	ENSMLUG00000006155	1 retrocopy	retro_mluc_1272,
Macaca mulatta	ENSMMUG00000006381	3 retrocopies	retro_mmul_1475, retro_mmul_2490, retro_mmul_537,
Mus musculus	ENSMUSG00000078784	3 retrocopies	retro_mmus_257, retro_mmus_2950, retro_mmus_3313,
Pongo abelii	ENSPPYG00000029910	3 retrocopies	retro_pabe_2345, retro_pabe_2630, retro_pabe_3633,
Pan troglodytes	ENSPTRG00000020385	5 retrocopies	retro_ptro_1759 , retro_ptro_2275, retro_ptro_2437, retro_ptro_2982, retro_ptro_471,
Rattus norvegicus	ENSRNOG00000038902	2 retrocopies	retro_rnor_2600, retro_rnor_496,
Sus scrofa	ENSSSCG00000006144	2 retrocopies	retro_sscr_342, retro_sscr_96,