RetrogeneDB ID: retro_pabe_825

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 12:19423324..19424656(+)
• Located in intron of: ENSPPYG00000004341

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: None
• Ensembl ID: ENSPPYG00000025948
• Aliases: None
• Description: None

Sequence

>retro_pabe_825
GGGCCAAGTCAGAGTGGTGGTCATGGTCCTGGAGGTGGCAAAAAGGATGACAAGTTCTAACAACTCAAGGACAAGAAAAA
GAAATATGAACCTCCTGTACCAACTAGAGTGGGGAAAAAGAAGAAGAAAACAAAGGGACCAGATGCTGCCAGCAAACTGC
CACTGGTGACACCTCACACTCAGTGCCCGTTAAAATTACTGAAGTTAAAGAGAATTAAAGACTATCTTCTCATGGAGGAA
GAATTCATTAGAAATCAGGAACAAATGAAACCATTAGAAGAAAAGCAAGAGGAGGAAAGATCAAAAGTAGATGATCTGAG
GGGGACCCCAATGTCAGTAGGAATCTTGGAAGAGATCATTGATGACAACCATGCCATCGTGTCTACATCTACGGGCTCAG
AACACCACGTCAGCATTCTTTCATTTGTAGACAAGGATCTGCTGGAAACTGGCTGCTCAGTCAGGCTCAACCACAAGGTG
CATACCATGATAGGGGTGCTGATGGATGACACGGATCCCCTGGTCACAGTGATGAAGGTGGAAAAGGCCCCCCAAGAGAC
CTTTGCAGATATTGGGGGGTTGGACAACCAAATTCAGGAAATTCAGGAATCTGTGGAGCTTCCTCTCACCCATCCTGAAT
ATTATGAAGAGATGAGTATAAAGCCTCCTAAGGGGGTCATTCTCTATGGTCCACCTGGCACAGGTAAAACCTTGTTAGCC
AAAGCAGTAGCAAACCAACCCTCAGCCACTTTCTTGAGAGTGGTTGGCTCTGAACTTATTCAGAAGTACCTAGGTGATGG
GCCCAAACTCGGAAGGGAATTGTTTCGAGTTGCTGAAGAACATGCACCGTCCATCGTGTTTATTGATTAAATTGATGCCA
TTGGGACAAAAAGATATGACTCCAATTCTGGTGGTGAGAGAGAAATTCGGCGAACAATGTTGGAACTGCTGAACCAGTTG
GATGGATTTGATTCTAGGGGAGATATGAAAGTTATCATGGTCGCAAACCGAATAGAAACTTTGGATCCAGCACTTATCAG
ACCAGGCCGCATTGACAGGAAGATTGAGTTCCCCCTGCCCGATGAAAAGACAAAGAAGTGCATCTTTCAGATTCACACAA
GCAGGATGACGCTGGCTGATGATGTAACCCTGGACGACTTGATCATGGCTAAAGATGACCTCTCTGGTGTTGACATCAAG
GCAATCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAATGCAGAATGAAAGTAACAAACGAAGACTTCAAAAAATCTAA
AGAAAATGTTCTTTATAAGAAACAGGAAGACACCCCTGAGGGTCTGTATCTC

Alignment

ORF - retro_pabe_825 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 91.44 %
• Parental protein coverage: 99.77 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  GQSQSGGHGPG-GGKKDD----KDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLE
          G.SQSGGHGPG.G.K.D.....KDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQC.LKLLKL.
Retrocopy GPSQSGGHGPGGGKKDDKF*QLKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCPLKLLKLK

Parental  RIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSIL
          RIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVG.LEEIIDDNHAIVSTS.GSEH.VSIL
Retrocopy RIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGILEEIIDDNHAIVSTSTGSEHHVSIL

Parental  SFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLT
          SFVDKDLLE.GCSV.LNHKVH..IGVLMDDTDPLVTVMKVEKAPQET.ADIGGLDN.......SVELPLT
Retrocopy SFVDKDLLETGCSVRLNHKVHTMIGVLMDDTDPLVTVMKVEKAPQETFADIGGLDNXXXXXXXSVELPLT

Parental  HPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEE
          HPEYYEEM.IKPPKGVILYGPPGTGKTLLAKAVANQ.SATFLRVVGSELIQKYLGDGPKL.RELFRVAEE
Retrocopy HPEYYEEMSIKPPKGVILYGPPGTGKTLLAKAVANQPSATFLRVVGSELIQKYLGDGPKLGRELFRVAEE

Parental  HAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGR
          HAPSIVFID.IDAIGTKRYDSNSGGEREI.RTMLELLNQLDGFDSRGD.KVIM..NRIETLDPALIRPGR
Retrocopy HAPSIVFID*IDAIGTKRYDSNSGGEREIRRTMLELLNQLDGFDSRGDMKVIMVANRIETLDPALIRPGR

Parental  IDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTN
          IDRKIEFPLPDEKTKK.IFQIHTSRMTLADDVTLDDLIMAKDDLSG.DIKAICTEAGLMALRE.RMKVTN
Retrocopy IDRKIEFPLPDEKTKKCIFQIHTSRMTLADDVTLDDLIMAKDDLSGVDIKAICTEAGLMALRECRMKVTN

Parental  EDFKKSKENVLYKKQEGTPEGLYL
          EDFKKSKENVLYKKQE.TPEGLYL
Retrocopy EDFKKSKENVLYKKQEDTPEGLYL

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.06 RPM	52.80 RPM
SRP007412_cerebellum	0.00 RPM	42.93 RPM
SRP007412_heart	0.00 RPM	32.33 RPM
SRP007412_kidney	0.00 RPM	37.82 RPM
SRP007412_liver	0.00 RPM	34.70 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_825 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_825 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_825 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_975
Pan troglodytes	retro_ptro_672
Gorilla gorilla	retro_ggor_780

---

Parental genes homology:

Parental genes homology involve 25 parental genes, and 101 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000001839	4 retrocopies	retro_amel_1536, retro_amel_1886, retro_amel_405, retro_amel_962,
Canis familiaris	ENSCAFG00000017510	2 retrocopies	retro_cfam_1238, retro_cfam_1562,
Choloepus hoffmanni	ENSCHOG00000013595	1 retrocopy	retro_chof_1954,
Callithrix jacchus	ENSCJAG00000017701	7 retrocopies	retro_cjac_1152, retro_cjac_1537, retro_cjac_2417, retro_cjac_2433, retro_cjac_4219, retro_cjac_661, retro_cjac_678,
Cavia porcellus	ENSCPOG00000002424	1 retrocopy	retro_cpor_144,
Dasypus novemcinctus	ENSDNOG00000006458	1 retrocopy	retro_dnov_2162,
Equus caballus	ENSECAG00000003601	1 retrocopy	retro_ecab_355,
Echinops telfairi	ENSETEG00000002661	1 retrocopy	retro_etel_580,
Felis catus	ENSFCAG00000011310	8 retrocopies	retro_fcat_1444, retro_fcat_1559, retro_fcat_2015, retro_fcat_344, retro_fcat_614, retro_fcat_691, retro_fcat_713, retro_fcat_924,
Homo sapiens	ENSG00000100764	10 retrocopies	retro_hsap_1090, retro_hsap_1278, retro_hsap_2080, retro_hsap_2658, retro_hsap_2810, retro_hsap_2873, retro_hsap_3323, retro_hsap_3416, retro_hsap_3793, retro_hsap_975,
Gorilla gorilla	ENSGGOG00000010620	8 retrocopies	retro_ggor_1004, retro_ggor_1298, retro_ggor_1629, retro_ggor_1954, retro_ggor_1993, retro_ggor_2309, retro_ggor_780, retro_ggor_858,
Macropus eugenii	ENSMEUG00000001526	1 retrocopy	retro_meug_623,
Microcebus murinus	ENSMICG00000016733	7 retrocopies	retro_mmur_1039, retro_mmur_1063, retro_mmur_1245, retro_mmur_1577, retro_mmur_216, retro_mmur_839, retro_mmur_983,
Myotis lucifugus	ENSMLUG00000007471	2 retrocopies	retro_mluc_2490, retro_mluc_508,
Macaca mulatta	ENSMMUG00000022990	1 retrocopy	retro_mmul_255,
Mustela putorius furo	ENSMPUG00000008150	4 retrocopies	retro_mputfur_1602, retro_mputfur_409, retro_mputfur_654, retro_mputfur_815,
Mus musculus	ENSMUSG00000021178	3 retrocopies	retro_mmus_1517, retro_mmus_1826, retro_mmus_812,
Nomascus leucogenys	ENSNLEG00000017013	10 retrocopies	retro_nleu_1123, retro_nleu_1163, retro_nleu_1589, retro_nleu_1625, retro_nleu_1669, retro_nleu_2318, retro_nleu_2625, retro_nleu_429, retro_nleu_616, retro_nleu_706,
Oryctolagus cuniculus	ENSOCUG00000006231	4 retrocopies	retro_ocun_1135, retro_ocun_1212, retro_ocun_1654, retro_ocun_411,
Otolemur garnettii	ENSOGAG00000032343	2 retrocopies	retro_ogar_3014, retro_ogar_367,
Pongo abelii	ENSPPYG00000025948	9 retrocopies	retro_pabe_1059, retro_pabe_153, retro_pabe_2379, retro_pabe_2408, retro_pabe_2737, retro_pabe_2832, retro_pabe_3099, retro_pabe_825 , retro_pabe_907,
Pan troglodytes	ENSPTRG00000006623	9 retrocopies	retro_ptro_1530, retro_ptro_1904, retro_ptro_1944, retro_ptro_2153, retro_ptro_2321, retro_ptro_2573, retro_ptro_672, retro_ptro_742, retro_ptro_874,
Pteropus vampyrus	ENSPVAG00000010020	3 retrocopies	retro_pvam_1190, retro_pvam_350, retro_pvam_500,
Ictidomys tridecemlineatus	ENSSTOG00000001655	1 retrocopy	retro_itri_780,
Tursiops truncatus	ENSTTRG00000013582	1 retrocopy	retro_ttru_239,