RetrogeneDB ID: retro_pabe_3686

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: X:112523482..112524009(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: PPIH
• Ensembl ID: ENSPPYG00000001467
• Aliases: None
• Description: peptidylprolyl isomerase H (cyclophilin H) [Source:HGNC Symbol;Acc:14651]

Sequence

>retro_pabe_3686
ATGGTGGTGGCAAATTCAAGCCCTGAGCCCCCGTGGTGTTCTTTGATGTCAGCATTGGCAGTCAGGAAGTTGGCCACATG
AAGATCCAGCTCTTTGTAGACATTGTGCCTAACACAGCTGAGAACTTTGGGCAGTTCTGCACTGGAGAATTCAGAAAAGA
TCGGGTTCCAATAGGATACAAAGGGAGCACCTTTCACAGGGTCATAAAGGATTTCATGATTCAGGGTGGAGATTTTGTTA
ATGGAGATGTTACTGGAGTCACCAGCATTTACCAGGGACCATTTGCAGATGAAAATTTTAAAATCAGATACCCAGCTCCA
GTCCTGCTTTCCATGGTGAACAGCAGTCCCAGTACAAATGGCTGTTAGTTCTTTCTCACCCGCTCTAAGTGCAATGGTCT
GGATGGGAAGCATGTAGTGTTTGGAAAAATCATTGACGGACTTCTACTGATGAGAAAGATTGAAAATGTTCCCACAGGCA
CCAATACTAAGGCCAAGGTACATATGGTGATCTCACGGTGTGGGGAG

Alignment

ORF - retro_pabe_3686 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 80.79 %
• Parental protein coverage: 99.44 %
• Number of stop codons detected: 1
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  MAVANSSPVNP-VVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVI
          M.VANSSP..P.VVFFDVSIG.QEVG.MKI.LF.D.VP.TAENF.QFCTGEFRKD.VPIGYKGSTFHRVI
Retrocopy MVVANSSPEPP<VVFFDVSIGSQEVGHMKIQLFVDIVPNTAENFGQFCTGEFRKDRVPIGYKGSTFHRVI

Parental  KDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHV
          KDFMIQGGDFVNGD.TGV.SIY.GPFADENFK.R..AP.LLSM.NS.PSTNGC.FF.T.SKC..LDGKHV
Retrocopy KDFMIQGGDFVNGDVTGVTSIYQGPFADENFKIRYPAPVLLSMVNSSPSTNGC*FFLTRSKCNGLDGKHV

Parental  VFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGE
          VFGKIIDGLL.MRKIENVPTG.N.K.K...VIS.CGE
Retrocopy VFGKIIDGLLLMRKIENVPTGTNTKAKVHMVISRCGE

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	18.25 RPM
SRP007412_cerebellum	0.00 RPM	8.15 RPM
SRP007412_heart	0.00 RPM	5.12 RPM
SRP007412_kidney	0.00 RPM	10.44 RPM
SRP007412_liver	0.00 RPM	9.21 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_3686 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_3686 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_3686 has 4 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_4740
Pan troglodytes	retro_ptro_3155
Gorilla gorilla	retro_ggor_2945
Callithrix jacchus	retro_cjac_4110

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Parental genes homology:

Parental genes homology involve 20 parental genes, and 42 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000000526	1 retrocopy	retro_amel_1481,
Bos taurus	ENSBTAG00000004590	1 retrocopy	retro_btau_1530,
Callithrix jacchus	ENSCJAG00000003145	5 retrocopies	retro_cjac_129, retro_cjac_1886, retro_cjac_2205, retro_cjac_3120, retro_cjac_4110,
Cavia porcellus	ENSCPOG00000008214	8 retrocopies	retro_cpor_1511, retro_cpor_785, retro_cpor_786, retro_cpor_794, retro_cpor_795, retro_cpor_796, retro_cpor_797, retro_cpor_798,
Dipodomys ordii	ENSDORG00000016152	3 retrocopies	retro_dord_151, retro_dord_173, retro_dord_447,
Homo sapiens	ENSG00000171960	2 retrocopies	retro_hsap_4740, retro_hsap_928,
Gorilla gorilla	ENSGGOG00000022507	2 retrocopies	retro_ggor_2945, retro_ggor_748,
Macropus eugenii	ENSMEUG00000001691	1 retrocopy	retro_meug_1699,
Myotis lucifugus	ENSMLUG00000025400	2 retrocopies	retro_mluc_1922, retro_mluc_2243,
Macaca mulatta	ENSMMUG00000013129	1 retrocopy	retro_mmul_1124,
Mustela putorius furo	ENSMPUG00000013966	2 retrocopies	retro_mputfur_285, retro_mputfur_542,
Nomascus leucogenys	ENSNLEG00000012313	2 retrocopies	retro_nleu_1242, retro_nleu_289,
Oryctolagus cuniculus	ENSOCUG00000011453	1 retrocopy	retro_ocun_1195,
Procavia capensis	ENSPCAG00000011139	1 retrocopy	retro_pcap_81,
Pongo abelii	ENSPPYG00000001467	2 retrocopies	retro_pabe_3686 , retro_pabe_797,
Pongo abelii	ENSPPYG00000016554	1 retrocopy	retro_pabe_2009,
Pan troglodytes	ENSPTRG00000000614	2 retrocopies	retro_ptro_3155, retro_ptro_644,
Pteropus vampyrus	ENSPVAG00000005500	1 retrocopy	retro_pvam_107,
Ictidomys tridecemlineatus	ENSSTOG00000000115	2 retrocopies	retro_itri_1248, retro_itri_412,
Tarsius syrichta	ENSTSYG00000003182	2 retrocopies	retro_tsyr_224, retro_tsyr_647,