RetrogeneDB ID: retro_mmul_2260

Retrocopy location

• Organism: Rhesus macaque (Macaca mulatta)
• Coordinates: 7:124831275..124831782(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: MMU.4198
• Ensembl ID: ENSMMUG00000006763
• Aliases: None
• Description: cytochrome c oxidase subunit IV isoform 1 [Source:RefSeq peptide;Acc:NP_001180477]

Sequence

>retro_mmul_2260
ATGTTGCCTACCAGGGTATTTAGCCTAGTTGGCAAGCGAGCAATTTCCAAATCGGCGTCTGTACGAGCACACGGAAATGA
TGTGAAGAGCGATGACAATGCGCTCCCAGCTTATGTGGATCGATGTGACTATCCCTTACCTGATGTGGCTCATGTCAAGC
ACCTGTCTGCCAGATAGCAGGCCTTGAAGGAGGAGGAGAAGGCCTCCTGAAGCAACCTCTCCATGGATGAGAAAGTCAAG
TTGTATTGCATTCAGTTCAAGGAGAGCTTTGCGGAGATGAACAGGGGTGCGAACGAGTGGAAGACGGTTGTTGGCGCTGC
CATGTTCTTCATTGGCTTCACGGCGTTGATTATCATCTGGGAGAAGCGCTGTTTGTACGGCCCCATCCCGCACATCTTTG
ACAAATAGTGGGTGGGCCATGCAGACCAAGAGGGTGCTGGACATGAGGTGAACCCCGTGCAGGGCTTTGCCGCCAAATGG
GACTATGACAAGAACGAGTGGAAGAAG

Alignment

ORF - retro_mmul_2260 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 76.02 %
• Parental protein coverage: 100.0 %
• Number of stop codons detected: 3
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  MLATRVFSLVGKRAISTSVCVRAHESVVKSEDFMLPAYVDRRDYPLPDVAHVKHLSASQKALKEKEKASW
          ML.TRVFSLVGKRAIS.S..VRAH...VKS.D..LPAYVDR.DYPLPDVAHVKHLSA...ALKE.EKAS.
Retrocopy MLPTRVFSLVGKRAISKSASVRAHGNDVKSDDNALPAYVDRCDYPLPDVAHVKHLSAR*QALKEEEKAS*

Parental  SSLSMDEKVELYRIKFKESFAEMNRRSNEWKTVVGTAMFFIGITALVIMWEKLYVYGPLPQTFDKEWV-A
          S.LSMDEKV.LY.I.FKESFAEMNR..NEWKTVVG.AMFFIG.TAL.I.WEK...YGP.P..FDK.WV.A
Retrocopy SNLSMDEKVKLYCIQFKESFAEMNRGANEWKTVVGAAMFFIGFTALIIIWEKRCLYGPIPHIFDK*WV>A

Parental  MQTKRMLDMK-VNPIQGLASKWDYEKNEWKK
          MQTKR.LDM..VNP.QG.A.KWDY.KNEWKK
Retrocopy MQTKRVLDMR<VNPVQGFAAKWDYDKNEWKK

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	0.00 RPM	119.89 RPM
SRP007412_brain_prefrontal_cortex	0.24 RPM	285.91 RPM
SRP007412_cerebellum	0.00 RPM	101.77 RPM
SRP007412_heart	0.06 RPM	342.18 RPM
SRP007412_kidney	0.00 RPM	204.46 RPM
SRP007412_liver	0.00 RPM	178.56 RPM
SRP007412_testis	0.00 RPM	95.70 RPM

ChIP-Seq

Macaca mulatta was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_mmul_2260 retrocopy.

TSS

Macaca mulatta was not studied using FANTOM5 data.

Lab

retro_mmul_2260 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmul_2260 has 4 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_1428
Pan troglodytes	retro_ptro_977
Gorilla gorilla	retro_ggor_1101
Pongo abelii	retro_pabe_1184

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Parental genes homology:

Parental genes homology involve 20 parental genes, and 42 retrocopies.

Species	Parental gene accession	Retrocopies number
Anolis carolinensis	ENSACAG00000005479	1 retrocopy	retro_acar_90,
Ailuropoda melanoleuca	ENSAMEG00000018274	1 retrocopy	retro_amel_470,
Bos taurus	ENSBTAG00000016079	2 retrocopies	retro_btau_1406, retro_btau_483,
Canis familiaris	ENSCAFG00000019921	2 retrocopies	retro_cfam_1259, retro_cfam_1906,
Callithrix jacchus	ENSCJAG00000017319	4 retrocopies	retro_cjac_2267, retro_cjac_3264, retro_cjac_3300, retro_cjac_802,
Dasypus novemcinctus	ENSDNOG00000017207	3 retrocopies	retro_dnov_2207, retro_dnov_2396, retro_dnov_737,
Equus caballus	ENSECAG00000011722	1 retrocopy	retro_ecab_418,
Felis catus	ENSFCAG00000007612	2 retrocopies	retro_fcat_1484, retro_fcat_853,
Homo sapiens	ENSG00000131143	1 retrocopy	retro_hsap_1428,
Gorilla gorilla	ENSGGOG00000010047	1 retrocopy	retro_ggor_1101,
Loxodonta africana	ENSLAFG00000014002	1 retrocopy	retro_lafr_528,
Macaca mulatta	ENSMMUG00000006763	4 retrocopies	retro_mmul_1129, retro_mmul_1285, retro_mmul_1724, retro_mmul_2260 ,
Mus musculus	ENSMUSG00000031818	2 retrocopies	retro_mmus_1305, retro_mmus_2958,
Nomascus leucogenys	ENSNLEG00000011409	1 retrocopy	retro_nleu_1843,
Oryctolagus cuniculus	ENSOCUG00000001735	5 retrocopies	retro_ocun_1238, retro_ocun_1333, retro_ocun_317, retro_ocun_469, retro_ocun_889,
Ochotona princeps	ENSOPRG00000002129	4 retrocopies	retro_opri_1205, retro_opri_267, retro_opri_821, retro_opri_857,
Pongo abelii	ENSPPYG00000007619	3 retrocopies	retro_pabe_1183, retro_pabe_1184, retro_pabe_996,
Pan troglodytes	ENSPTRG00000008434	1 retrocopy	retro_ptro_977,
Rattus norvegicus	ENSRNOG00000017817	1 retrocopy	retro_rnor_1157,
Tarsius syrichta	ENSTSYG00000009682	2 retrocopies	retro_tsyr_2073, retro_tsyr_591,