RetrogeneDB ID: retro_ggor_3026

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: X:65220612..65221472(-)
• Located in intron of: ENSGGOG00000034944

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: PGK1
• Ensembl ID: ENSGGOG00000017111
• Aliases: None
• Description: Phosphoglycerate kinase [Source:UniProtKB/TrEMBL;Acc:G3RLP0]

Sequence

>retro_ggor_3026
AAGGGAAGGGAAAACTCTGGGAACAAGGTTAAAGTGAGCCCGCCAAAGTAGAAGCTTTCCGAGCTTCACTTTCCAAGCTA
GGGAATGTGTATGTCAATGATGCTTTTGGCACTGCTCACAGGGCCCACAGCTCCATGGTAGGAGTCAGTCTGCCACAGAA
GGCTGGTGGTTTTTTGATGAAGAAGGAGCTGAACTACTTTGTGAAGGTCTTGGAGAGCCCATAGCGACCCTTCCTGGCCA
TTCTGGGTGGAGCTAAATTTGCAGACAAGATCCACCTGATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGT
GGTGGAACGGCTTTTACCTTCCTTAAGGTGCTCAACAACATGGAGACTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAA
GATTGTCAAAGACCTAATGTCCCAAGCTGAGAAGAATGGTGTGAAGATTACCTTGCCTATTGACTTTGTCACTGCTGAGA
AATTTGATGAGAATGCCAAGACTGGCCAAGCCACTGTGGCTTCTGGCATACCTGCTGGCTGAATGGGCTTGGACTGTGGT
CCTGAAAGCAGCAAGAAGTATGCTGAGACTGTCACTTGGGCTAAGCAGATTGTGTGGAATGGTCCTGTGGGGGTATTTGA
ATGGGAAGCTTTTGCCCAGGGAACCAAAGCCCTCATGGATGAGGTGGTGAAAGCCACTTCTAGGGGCTGCATTACCATCA
TAGGTGGTGGAAACACTGCCACTTGCTGTGCCAAATGGAACACAGAGGATAAAATCAGACATGTGAGCACTAGGGGTGGT
GCCAGTTTAGAGCTCCTGGACGGTAAAGTCCTTCCTGGGGTGGATGCTCTCAGCAATATT

Alignment

ORF - retro_ggor_3026 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 90.62 %
• Parental protein coverage: 75.73 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  KGKDASGNKVK-AEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAK
          KG...SGNKVK..EPAK.EAFRASLSKLG.VYVNDAFGTAHRAHSSMVGV.LPQKAGGFLMKKELNYF.K
Retrocopy KGRENSGNKVK<SEPAKVEAFRASLSKLGNVYVNDAFGTAHRAHSSMVGVSLPQKAGGFLMKKELNYFVK

Parental  ALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDL
          .LESP.RPFLAILGGAK.ADKI.LINNMLDKVNEMIIGGG.AFTFLKVLNNME.GTSLFDEEGAKIVKDL
Retrocopy VLESP*RPFLAILGGAKFADKIHLINNMLDKVNEMIIGGGTAFTFLKVLNNMETGTSLFDEEGAKIVKDL

Parental  MSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGP
          MS.AEKNGVKITLP.DFVTA.KFDENAKTGQATVASGIPAG.MGLDCGPESSKKYAE.VT.AKQIVWNGP
Retrocopy MSQAEKNGVKITLPIDFVTAEKFDENAKTGQATVASGIPAG*MGLDCGPESSKKYAETVTWAKQIVWNGP

Parental  VGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLP
          VGVFEWEAFA.GTKALMDEVVKATSRGCITIIGGG.TATCCAKWNTEDK..HVST.GGASLELL.GKVLP
Retrocopy VGVFEWEAFAQGTKALMDEVVKATSRGCITIIGGGNTATCCAKWNTEDKIRHVSTRGGASLELLDGKVLP

Parental  GVDALSNI
          GVDALSNI
Retrocopy GVDALSNI

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.24 RPM	255.59 RPM
SRP007412_cerebellum	0.08 RPM	129.19 RPM
SRP007412_heart	0.06 RPM	92.46 RPM
SRP007412_kidney	0.12 RPM	164.37 RPM
SRP007412_liver	0.00 RPM	56.95 RPM
SRP007412_testis	0.00 RPM	87.96 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_3026 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_3026 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_4850
Pan troglodytes	retro_ptro_3229
Pongo abelii	retro_pabe_3770

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Parental genes homology:

Parental genes homology involve 29 parental genes, and 52 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000017619	1 retrocopy	retro_amel_117,
Bos taurus	ENSBTAG00000000894	1 retrocopy	retro_btau_1021,
Canis familiaris	ENSCAFG00000017270	2 retrocopies	retro_cfam_1194, retro_cfam_510,
Callithrix jacchus	ENSCJAG00000021082	3 retrocopies	retro_cjac_1367, retro_cjac_137, retro_cjac_4171,
Cavia porcellus	ENSCPOG00000023785	1 retrocopy	retro_cpor_102,
Equus caballus	ENSECAG00000014984	1 retrocopy	retro_ecab_557,
Felis catus	ENSFCAG00000013209	2 retrocopies	retro_fcat_123, retro_fcat_316,
Homo sapiens	ENSG00000102144	2 retrocopies	retro_hsap_1966, retro_hsap_90,
Gorilla gorilla	ENSGGOG00000017111	3 retrocopies	retro_ggor_1429, retro_ggor_2420, retro_ggor_3026 ,
Loxodonta africana	ENSLAFG00000011954	1 retrocopy	retro_lafr_13,
Macropus eugenii	ENSMEUG00000004779	3 retrocopies	retro_meug_11, retro_meug_1649, retro_meug_400,
Myotis lucifugus	ENSMLUG00000017791	2 retrocopies	retro_mluc_1657, retro_mluc_2159,
Macaca mulatta	ENSMMUG00000012874	1 retrocopy	retro_mmul_144,
Monodelphis domestica	ENSMODG00000004055	2 retrocopies	retro_mdom_140, retro_mdom_170,
Mus musculus	ENSMUSG00000062070	2 retrocopies	retro_mmus_29, retro_mmus_9,
Nomascus leucogenys	ENSNLEG00000001423	3 retrocopies	retro_nleu_2372, retro_nleu_2610, retro_nleu_79,
Oryctolagus cuniculus	ENSOCUG00000014726	1 retrocopy	retro_ocun_171,
Otolemur garnettii	ENSOGAG00000011104	1 retrocopy	retro_ogar_73,
Procavia capensis	ENSPCAG00000002117	1 retrocopy	retro_pcap_17,
Pongo abelii	ENSPPYG00000020496	3 retrocopies	retro_pabe_134, retro_pabe_1624, retro_pabe_3770,
Pan troglodytes	ENSPTRG00000022052	2 retrocopies	retro_ptro_2, retro_ptro_3229,
Rattus norvegicus	ENSRNOG00000002467	7 retrocopies	retro_rnor_1526, retro_rnor_1527, retro_rnor_2603, retro_rnor_3, retro_rnor_462, retro_rnor_590, retro_rnor_611,
Sorex araneus	ENSSARG00000003956	1 retrocopy	retro_sara_14,
Sarcophilus harrisii	ENSSHAG00000001853	1 retrocopy	retro_shar_11,
Sus scrofa	ENSSSCG00000012440	1 retrocopy	retro_sscr_933,
Ictidomys tridecemlineatus	ENSSTOG00000001972	1 retrocopy	retro_itri_65,
Tupaia belangeri	ENSTBEG00000010309	1 retrocopy	retro_tbel_35,
Tarsius syrichta	ENSTSYG00000007917	1 retrocopy	retro_tsyr_40,
Vicugna pacos	ENSVPAG00000001208	1 retrocopy	retro_vpac_21,