RetrogeneDB ID: retro_ggor_1044

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 14:38454875..38455458(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSGGOG00000022957
• Aliases: None
• Status: KNOWN_PSEUDOGENE

Parental gene information

• Parental gene symbol: SRSF10
• Ensembl ID: ENSGGOG00000000392
• Aliases: None
• Description: serine/arginine-rich splicing factor 10 [Source:HGNC Symbol;Acc:16713]

Sequence

>retro_ggor_1044
AACACATCTCTCTTCTTCAGGAACGTGGCCGATGACACCAGGTATGAAGATTTACAGTGTGAACTTGGTCATTATGGTCC
TATAGTTGATGTGTATGTTCCGCTTGATTTCTACATTCGCCGTCCAAGAGGATTTGCTTATATTCAATTTGAGGATGTTT
GTGATGCTGAAGATGCTTACATAATTTGGACAGAAAGTGGATTTGTGGATGGCAGATTAAAATACAGTTTGCCAAGGGGG
ATCAGAAGACACTAAATCAGATGAAAGCCAAGGAAGGGAAGAATGTGTACAGTTCTTCATGCTATGATGATTATGACAGA
TACAGACATTCTAGAAGCCAAAGTTGTAAAAGAAGGAGATCAAGAAGGCGATCTTCTGATTACAACTATAGAAGGTCGTA
TAGTCCTAGAAAGAGTAGACCGACTGGAAGACCACACATGGCAGAAGCCATTCCAAATATCATAGATTCAAACACTGAAA
TTAATCTTTTTCAAAATCTAAATCCAATTCAAGATCACGGTCCAAGTCCCAGCCCAAGAGAGAAATGAAGGCTGAATCAC
ATTCTAGGTCTGCATCTCACACC

Alignment

ORF - retro_ggor_1044 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 80.4 %
• Parental protein coverage: 96.1 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  NTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQYTFEDVRDAEDA-LHNLDRKW
          NTSLF.RNVADDTR.EDL..E.G.YGPIVDVYVPLDFY.RRPRGFAY.Q..FEDV.DAEDA.LHNLDRKW
Retrocopy NTSLFFRNVADDTRYEDLQCELGHYGPIVDVYVPLDFYIRRPRGFAYIQ--FEDVCDAEDA<LHNLDRKW

Parental  ICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPR
          ICG.QI.IQFA.GD.KT.NQMKAKEG.NVYSSS.YDDYDRYR.SRS.S..RRRSR.RS.DYNYRRSYSPR
Retrocopy ICGWQIKIQFAKGDQKTLNQMKAKEGKNVYSSSCYDDYDRYRHSRSQSCKRRRSRRRSSDYNYRRSYSPR

Parental  NSRPTGRPR-RSRSHSDNDRFKHRNRSFSRSKSNSRSRSKSQPKKEMKAKSRSRSASHT
          .SRPTGRP....RSHS...RFKH.N.SFS.SKSNSRSRSKSQPK.EMKA.S.SRSASHT
Retrocopy KSRPTGRPH<HGRSHSKYHRFKH*N*SFSKSKSNSRSRSKSQPKREMKAESHSRSASHT

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.05 RPM	12.08 RPM
SRP007412_cerebellum	0.16 RPM	14.70 RPM
SRP007412_heart	0.00 RPM	4.19 RPM
SRP007412_kidney	0.12 RPM	14.23 RPM
SRP007412_liver	0.05 RPM	10.02 RPM
SRP007412_testis	0.10 RPM	58.02 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_1044 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_1044 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_1343
Pan troglodytes	retro_ptro_918
Pongo abelii	retro_pabe_1115

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Parental genes homology:

Parental genes homology involve 19 parental genes, and 46 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000009869	2 retrocopies	retro_amel_1810, retro_amel_355,
Bos taurus	ENSBTAG00000008072	1 retrocopy	retro_btau_759,
Choloepus hoffmanni	ENSCHOG00000004836	1 retrocopy	retro_chof_7,
Callithrix jacchus	ENSCJAG00000020883	9 retrocopies	retro_cjac_1126, retro_cjac_1170, retro_cjac_2176, retro_cjac_2595, retro_cjac_2638, retro_cjac_3852, retro_cjac_628, retro_cjac_705, retro_cjac_864,
Cavia porcellus	ENSCPOG00000024533	1 retrocopy	retro_cpor_1098,
Dasypus novemcinctus	ENSDNOG00000008699	3 retrocopies	retro_dnov_1327, retro_dnov_1809, retro_dnov_2244,
Erinaceus europaeus	ENSEEUG00000014286	1 retrocopy	retro_eeur_522,
Homo sapiens	ENSG00000188529	5 retrocopies	retro_hsap_1343, retro_hsap_1940, retro_hsap_2445, retro_hsap_3054, retro_hsap_4295,
Gorilla gorilla	ENSGGOG00000000392	4 retrocopies	retro_ggor_1044 , retro_ggor_1411, retro_ggor_1522, retro_ggor_2870,
Gorilla gorilla	ENSGGOG00000014378	1 retrocopy	retro_ggor_2895,
Myotis lucifugus	ENSMLUG00000028520	1 retrocopy	retro_mluc_89,
Mustela putorius furo	ENSMPUG00000015845	1 retrocopy	retro_mputfur_353,
Nomascus leucogenys	ENSNLEG00000013180	3 retrocopies	retro_nleu_1647, retro_nleu_1825, retro_nleu_202,
Oryctolagus cuniculus	ENSOCUG00000029326	1 retrocopy	retro_ocun_717,
Otolemur garnettii	ENSOGAG00000015374	2 retrocopies	retro_ogar_2650, retro_ogar_2987,
Pongo abelii	ENSPPYG00000001726	4 retrocopies	retro_pabe_1115, retro_pabe_1601, retro_pabe_1796, retro_pabe_2529,
Rattus norvegicus	ENSRNOG00000007992	3 retrocopies	retro_rnor_1657, retro_rnor_2800, retro_rnor_2829,
Ictidomys tridecemlineatus	ENSSTOG00000000956	1 retrocopy	retro_itri_1333,
Tursiops truncatus	ENSTTRG00000016150	2 retrocopies	retro_ttru_1098, retro_ttru_695,