RetrogeneDB ID: retro_ggor_2932

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: X:77652797..77654696(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: WBP11
• Ensembl ID: ENSGGOG00000004448
• Aliases: None
• Description: None

Sequence

>retro_ggor_2932
AGATCTACATCATCCACCAAGAGTGGAAACTTTATGAACCCCATAGACCAAGCCCAAAAGGAAGCCCGGAAGAGAGAATT
GAAGAAGAGCAAAAAACAGCACATGATGGTTCCAGCTCCAGTTTTAAGGATGAAGGATCCCAAACAGATTATCTGAGACA
TGGAGAAATTGGATGAAATGGAGTTTAACCCAGTATAACAGCCACAATTAAATGAGAAAGTATTAAAAGACAAGTGTAAA
AAGCTGCGTGAAACCTTTGGTATTCTACAACTCTATGAAAAAGAGAATCCAGATATTTACAAAGAACTGAGAAAGCTAGA
AGTAGAGTATAAACAGAAGAGGGCTCAACTTAGCCAATATTTTGATGCCGTCAAGAATGCTCTGCATGTGGAAATGGAGA
GTATTCCTTTGTCAGATATGCCACATATTCCTTCCAACATTTTGATCCAAGACATTCCACTTCCTGGTGCCCAGCCACCC
TCCATCCTTAAGAAAACCTCAGCCTATGGACGTCCAACTCGGGCAGTTTCTATCCTGGCTCTTCTTGGACATGGTGTTCC
ACGTTCGCTCCATGGCAGAAAACCTCTTTGCCCTCTCTCTGGCCCACCTCCTCCTCAAGTCGTGCAGATGTACGGCCGTA
AAGTGTGTTTCGCCCTAGATTTTCCCCCACGTAGGCGAGATGAAGACATATTTTATAGTCCTGCACTTGCCCAGAGAGGT
CATGATTATGATGTTTCTAGCACCAGTGAAGATGATGGCTATCCTGAGGACATGGATCAAGATAAGCATGATGAAAGTAC
TGATGACAGTGACACCAACGGATCAGATGGAGAAAGTGAGGAGGATGAATTTGTGCACCATGATGATGGTGAGAGAGACA
ACAATGAAGAAAAGAAGTCAGGTCCTAGTGTACAGTTTGCAAATATGTGGAAAATCAAGGAAAAAAAGAAGAACATGAAG
GAACTAACTCCTCTTCAAGCTATGATGCTTCGTATGGCAGGTCAAGAAATCCTTGAGGAGTGATGGGCAGTAGAAGAATT
TTCAGCGGACGGTGATGAAGATGATTCTGATGACTCTGAAGCAGAAAAGCAATCATAAAAACAGAATAAAGAAGAATCTC
ATGCTGATGGCACATCCACTGCTTCTTCATAGCAGCAGGCTCCCCCGCGGTCTGCTCCTCCTTCTCAGATAAAAGCACCT
CCCATGCCAGGACCACCACCTCTTGGACCACCACCTGCTCTACCATTACGGCCTCCTGGGCCACCTACGGGCCTTCCTCC
TGGTCCACCTCCAGGAGCTCCTCCATTACTGAGACCATCTGAAATGCCAGGACTCCAAGGGCCTTTACCCCAACTTTTAC
CTCCAGGACCACCATGAGGCTTGACCCCCTGTCCCTTTCCCAGGTCCAACTGCAGGTATGCCTCCTGGTCCCCCTCCTTG
GAGACCCCCACCAAGAGTACCTCCAGGTATTCCCTCACCTTGTCCCGGCATGATGCGCCCACCTTTGGTGCCTCACCTTG
GACCTGCCCCCCTGGGTTTTTCCCACCACCTCCCTAGCAGAACCCTGGGGTTTTTTTAAGTGCCCCACCCAACTTGATTC
AGCAACCCAAAGCGGATGATATGAGTGCAGCCACGATTGAGAAGAAAGCCACAGCAACCATCAGTGCCAAGTCACAGATC
AACAATACCAAGGCAGAGATTACTCTACTTCTGCCCACTGCACTGAGAGTTCGTTGGGAGAATAAAGGGGCTACTGCTGC
TCCCCAAAGAAAGTCAGAGGATGATTCTGCTGTGCCTCTTGCCAAAGCAGCACCCAAATCTGGTTCTTCTGTTCCTGTCT
CAGTACAAACTAAGGATGATGTCTATGAGGTTTTCATGAAAGAGATGGAAGGGCTACTC

Alignment

ORF - retro_ggor_2932 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 81.28 %
• Parental protein coverage: 99.53 %
• Number of stop codons detected: 7
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  RSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPKQIIRDMEKLDEMEFNPVQQPQL
          RSTSSTKSG.FMNP.DQA.KEARKRELKK.KKQ.MMV.A.VL.MKDPKQII.DMEKLDEMEFNPV.QPQL
Retrocopy RSTSSTKSGNFMNPIDQAQKEARKRELKKSKKQHMMVPAPVLRMKDPKQII*DMEKLDEMEFNPV*QPQL

Parental  NEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVESIPLPD
          NEKVLKDK.KKLRETF..IL.LYEKENPDIYKELRKLEVEY.QKRAQLSQYFDAVKNA.HVE.ESIPL.D
Retrocopy NEKVLKDKCKKLRETFG-ILQLYEKENPDIYKELRKLEVEYKQKRAQLSQYFDAVKNALHVEMESIPLSD

Parental  MPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPPPQVVQ
          MPH.PSNILIQDIPLPGAQPPSILKKTSAYG.PTRAVSIL.LLGHGVPR...GRKP..P..GPPPPQVVQ
Retrocopy MPHIPSNILIQDIPLPGAQPPSILKKTSAYGRPTRAVSILALLGHGVPRSLHGRKPLCPLSGPPPPQVVQ

Parental  MYGRKVGFALDLPPRRRDEDMLYSPELAQRGHDDDVSSTSEDDGYPEDMDQDKHDDSTDDSDTDKSDGES
          MYGRKV.FALD.PPRRRDED..YSP.LAQRGHD.DVSSTSEDDGYPEDMDQDKHD.STDDSDT..SDGES
Retrocopy MYGRKVCFALDFPPRRRDEDIFYSPALAQRGHDYDVSSTSEDDGYPEDMDQDKHDESTDDSDTNGSDGES

Parental  DGDEFVHRDDGERDNNEEKKSGLSVRFADMPGKSRKKKKNMKELTPLQAMMLRMAGQEIPEEGREVEEFS
          ..DEFVH.DDGERDNNEEKKSG.SV.FA.M..K...KKKNMKELTPLQAMMLRMAGQEI.EE...VEEFS
Retrocopy EEDEFVHHDDGERDNNEEKKSGPSVQFANM-WKIKEKKKNMKELTPLQAMMLRMAGQEILEE*WAVEEFS

Parental  EDDDEDDSDDSEAEKQSQKQHKEESHSDGTSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPPLRP
          .D.DEDDSDDSEAEKQS.KQ.KEESH.DGTSTASS.QQAPP.S.PPSQI.APPMPGPPPLGPPPA.PLR.
Retrocopy ADGDEDDSDDSEAEKQS*KQNKEESHADGTSTASS*QQAPPRSAPPSQIKAPPMPGPPPLGPPPALPLRX

Parental  PGPPTGLPPGPPPGAPPFLRPPGMPGLRGPLPRLLPPGPPPGR-PPGPPPGPPPGLPPGPPPRGPPPRLP
          ..................LRP..MPGL.GPLP.LLPPGPP.G..PP.P.PGP..G.PPGPPP..PPPR.P
Retrocopy XXXXXXXXXXXXXXXXXLLRPSEMPGLQGPLPQLLPPGPP*GL>PPVPFPGPTAGMPPGPPPWRPPPRVP

Parental  PPAPPGIPPPRPGMMRPPLVPPLGPA-PPGLFPPAPLPNPGV-LSAPPNLIQRPKADDTSAATIEKKATA
          P....GIP.P.PGMMRPPLVP.LGPA.PPG.FPP.P..NPGV.LSAPPNLIQ.PKADD.SAATIEKKATA
Retrocopy P----GIPSPCPGMMRPPLVPHLGPA<PPGFFPPPP*QNPGVFLSAPPNLIQQPKADDMSAATIEKKATA

Parental  TISAKPQITNPKAEITRFVPTALRVRRENKGATAAPQRKSEDDSAVPLAKAAPKSGPSVPVSVQTKDDVY
          TISAK.QI.N.KAEIT...PTALRVR.ENKGATAAPQRKSEDDSAVPLAKAAPKSG.SVPVSVQTKDDVY
Retrocopy TISAKSQINNTKAEITLLLPTALRVRWENKGATAAPQRKSEDDSAVPLAKAAPKSGSSVPVSVQTKDDVY

Parental  EAFMKEMEGLL
          E.FMKEMEGLL
Retrocopy EVFMKEMEGLL

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	69.39 RPM
SRP007412_cerebellum	0.00 RPM	51.53 RPM
SRP007412_heart	0.00 RPM	17.07 RPM
SRP007412_kidney	0.00 RPM	45.63 RPM
SRP007412_liver	0.00 RPM	30.91 RPM
SRP007412_testis	0.10 RPM	293.60 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_2932 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_2932 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_4719

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Parental genes homology:

Parental genes homology involve 22 parental genes, and 34 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000014759	1 retrocopy	retro_btau_20,
Canis familiaris	ENSCAFG00000012926	2 retrocopies	retro_cfam_1369, retro_cfam_1911,
Callithrix jacchus	ENSCJAG00000021611	1 retrocopy	retro_cjac_1737,
Homo sapiens	ENSG00000084463	2 retrocopies	retro_hsap_1878, retro_hsap_4719,
Gorilla gorilla	ENSGGOG00000004448	3 retrocopies	retro_ggor_1375, retro_ggor_1711, retro_ggor_2932 ,
Macropus eugenii	ENSMEUG00000013971	1 retrocopy	retro_meug_1952,
Myotis lucifugus	ENSMLUG00000015216	1 retrocopy	retro_mluc_1074,
Macaca mulatta	ENSMMUG00000019299	1 retrocopy	retro_mmul_1329,
Monodelphis domestica	ENSMODG00000017949	1 retrocopy	retro_mdom_143,
Mustela putorius furo	ENSMPUG00000011619	1 retrocopy	retro_mputfur_280,
Mus musculus	ENSMUSG00000030216	1 retrocopy	retro_mmus_2740,
Nomascus leucogenys	ENSNLEG00000003926	1 retrocopy	retro_nleu_2651,
Oryctolagus cuniculus	ENSOCUG00000017177	1 retrocopy	retro_ocun_974,
Otolemur garnettii	ENSOGAG00000010518	1 retrocopy	retro_ogar_207,
Ochotona princeps	ENSOPRG00000015008	3 retrocopies	retro_opri_107, retro_opri_1159, retro_opri_678,
Pongo abelii	ENSPPYG00000004323	3 retrocopies	retro_pabe_1558, retro_pabe_2099, retro_pabe_3663,
Pan troglodytes	ENSPTRG00000004724	3 retrocopies	retro_ptro_1260, retro_ptro_1637, retro_ptro_3136,
Rattus norvegicus	ENSRNOG00000005505	3 retrocopies	retro_rnor_1287, retro_rnor_2726, retro_rnor_741,
Rattus norvegicus	ENSRNOG00000049593	1 retrocopy	retro_rnor_740,
Sorex araneus	ENSSARG00000007085	1 retrocopy	retro_sara_753,
Sarcophilus harrisii	ENSSHAG00000016649	1 retrocopy	retro_shar_81,
Tupaia belangeri	ENSTBEG00000003394	1 retrocopy	retro_tbel_2213,