RetrogeneDB ID: retro_btau_20

Retrocopy location

• Organism: Cow (Bos taurus)
• Coordinates: 13:74496557..74498471(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSBTAG00000037942
• Aliases: None
• Status: KNOWN_PROTEIN_CODING

Parental gene information

• Parental gene symbol: BT.18030
• Ensembl ID: ENSBTAG00000014759
• Aliases: None
• Description: WW domain-binding protein 11 [Source:RefSeq peptide;Acc:NP_001193334]

Sequence

>retro_btau_20
ATGGGGCGGAGATCCACGTCATCCACCAAAAGTGGAAAATTTATGAACCCTACAGACCAAGCCAGAAAAGAAGCTCGGAA
AAGAGAATTAAAGAACAAAAAACAGCACATGATGGTACGAGCTGCAGTTTTAAAGATGAAGGATCCCAAACAAATTATCC
GGGACATGGAAAAATTGGATGAAATGGAGTTTAACCCAGTGCAGCAGCCACAGTTAAATAAGAAAGTGCTGAAAGACAAG
CGTAAAAAGCTACGTGAAACATATGAACGTATTCTACAACTCTATGAGAAAGAGAATCCAGATATTTACAAAGAATTGAG
AAAGTCAGAGGTAGAATATGAACAGAAGAGGGCTCAACTTAGCCAGTATTTTGATGCTGTCAAGAATGCCCAGCATGTGG
AAGTGGAGAGTATTCCTCTGCCAGATATGCCGCATGCTCCTTCCAGCATCTTGATCCAGGACATTCCACTTTCTGGGGCC
CAGCCACCCTCCATCCTTAAGAAGAACTCAGCCTATGGACCTCCAACTCGGGCAGTTTCTATACTTCCTCTTCTTGGACA
TGACGTTCCACGTTTGCCCCCTGGCAGGAAACCTCCAGGTCCTCCCCCGGGCCCACCTCCTCCTCAAGTCTTACAAATGT
ATGGCCACAAAGTGGGCTTTGCCCTAGATCTTCCGACTCGTAGGCGAGATGAAGACATGTTATATAGTCCTGAACTTGCT
CAGCGGGGTCATGACGATGATGTTTCCTGCACCAGTGAAGATGATGGCTATCCTGAAGACATGGACCAGGATAAGCATGA
TGACAGTACTGATGACAGCGACAGTGACAGATCAGGTGGAGAAAGTGAAGGGGATGAATTTGTGCACCGTGATGACACTG
AGAGAGAAAACAATGAAGAAAAAAAGTCAGGTCTGAGTGTACGGTTTGCAGATATGCCTGGAAAATCTAGGAAGAAGAAG
AACATGAAGGAGCTGACTCCTCTCCAAGCCATGATGCTTCAAATGGCAGGTCAGGAAATCCCTGAGGAGGGACGAGAAGT
CGAGGAATTTTCAGAGGAAGATGATGAAGATTCAGATGAGTCTGAAGCAGAAAAGCAATCACAGAAACAGCATAAGGAGG
AATCTCTCTCTGATGGCACGTCTGCAGCTTCCCAGCAGCAAGCCCCTCCACAGTCTGTTCCTCCATCTCAGATACAGGCA
CCCCCCATGCCAGGACCACCTCCGCTTGGACCGCCACCTGCTCCACCTTTACGGCCACCTGGACCACCGACAGGCCTTCC
TCCTGGACCACCTCCAGGAGCTCCTCCGTTCCTGAGACCGCCTGGAATGCCAGGACTCCAAGGGCCTCTGCCCCACCTTT
TACCTCCAGGCCCACCACCCGGTCGAACCCCTGGCCCTCCTCCTGGCCCACCCCCAGGTCTGCCTCCTGGCCCTCCTCCT
CGGGGACCCCCACCACAGCTACCTCCCCCGGCACCTCCAGGTATCCCTCCACCCCGTCCTGGCATGATGCGCCCACCTCT
GGTGCCTCCTCTTGGACCTGCCCCACCAGGGCTCTTTCCACCAGCTCCCTTACCCAACCCTGGGGTTCTAAGTGCTCCCC
CCAACTTGATCCAGAGACCCAAGGCGGATGACACAAGCACAGCCACCATCGAGAAGAAAGCCACGGCAACCATCAGTGCC
AAGCCACAGATCACTAATCCCAAGGCAGAGATCACACGATTTGTGCCGACCACACCGCGGGTGCGTCGGGAGAATAAAGG
GGCTGCTGCTGCTGCGCAGAGAAAGTCGGAGGATGATTCTGCTGTGCCTCTTGCCAAAACAGCACCCAAATCTGGCCCAT
CTCTTCCCGTGTCGGTGCAGACTAAGGACGATGTCTGTGAGGCTTTCATGAAAGAGATGGAAGGGCTGCTGTGA

Alignment

ORF - retro_btau_20 Open Reading Frame is conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 92.06 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 0
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  MGRRSTSSTKSGKFMNPTDQASKCPLILEKMLMKNKKQRMMVRAAVLKMKDPKQIIRDMEKLDEMEFNPV
          MGRR...ST.S.K................K...KNKKQ.MMVRAAVLKMKDPKQIIRDMEKLDEMEFNPV
Retrocopy MGRR---STSSTKSGKFMNPTDQARKEARKRELKNKKQHMMVRAAVLKMKDPKQIIRDMEKLDEMEFNPV

Parental  QQPQLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVES
          QQPQLN.KVLKDKRKKLRET.ERIL.LYEKENPDIYKELRK.EVEYEQKRAQLSQYFDAVKNAQHVEVES
Retrocopy QQPQLNKKVLKDKRKKLRETYERILQLYEKENPDIYKELRKSEVEYEQKRAQLSQYFDAVKNAQHVEVES

Parental  IPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPP
          IPLPDMPHAPS.ILIQDIPL.GAQPPSILKK.SAYGPPTRAVSILPLLGH.VPRLPPGRKPPGPPPGPPP
Retrocopy IPLPDMPHAPSSILIQDIPLSGAQPPSILKKNSAYGPPTRAVSILPLLGHDVPRLPPGRKPPGPPPGPPP

Parental  PQVLQMYGRKVGFALYLPTRRRDEDMLYSPELAQRGHDDDVSSTSEDDGYPEDMDQDKHDDSTDDSDSDR
          PQVLQMYG.KVGFAL.LPTRRRDEDMLYSPELAQRGHDDDVS.TSEDDGYPEDMDQDKHDDSTDDSDSDR
Retrocopy PQVLQMYGHKVGFALDLPTRRRDEDMLYSPELAQRGHDDDVSCTSEDDGYPEDMDQDKHDDSTDDSDSDR

Parental  SDGESEGDEFVHRDDTERENNEEKKSGLSVRFADMPGKSRKKKKKNMKELTPLQAMMLRMAGQEIPEEGR
          S.GESEGDEFVHRDDTERENNEEKKSGLSVRFADMPGKSRKKK..NMKELTPLQAMML.MAGQEIPEEGR
Retrocopy SGGESEGDEFVHRDDTERENNEEKKSGLSVRFADMPGKSRKKK--NMKELTPLQAMMLQMAGQEIPEEGR

Parental  EVEEFSEEDDEDSDDSEAEKQSQKQHKEESLSDGTSAASQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAP
          EVEEFSEEDDEDSD.SEAEKQSQKQHKEESLSDGTSAASQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAP
Retrocopy EVEEFSEEDDEDSDESEAEKQSQKQHKEESLSDGTSAASQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAP

Parental  PLRPPGPPTGLPPGPPPGAPPFLRPPGMPGLRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPP
          PLRPPGPPTGLPPGPPPGAPPFLRPPGMPGL.GPLP.LLPPGPPPGR.PGPPPGPPPGLPPGPPPRGPPP
Retrocopy PLRPPGPPTGLPPGPPPGAPPFLRPPGMPGLQGPLPHLLPPGPPPGRTPGPPPGPPPGLPPGPPPRGPPP

Parental  RLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPNLIQRPKADDTSAATIEKKAT
          .LPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPNLIQRPKADDTS.ATIEKKAT
Retrocopy QLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPNLIQRPKADDTSTATIEKKAT

Parental  ATISAKPQITNPKAEITRFVPTALRVRRENKGAAAAPQRKSEDDSAVPLAKTAPKSGPSVPVSVQTKDDV
          ATISAKPQITNPKAEITRFVPT..RVRRENKGAAAA.QRKSEDDSAVPLAKTAPKSGPS.PVSVQTKDDV
Retrocopy ATISAKPQITNPKAEITRFVPTTPRVRRENKGAAAAAQRKSEDDSAVPLAKTAPKSGPSLPVSVQTKDDV

Parental  YEAFMKEMEGLL
          .EAFMKEMEGLL
Retrocopy CEAFMKEMEGLL

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
ERP005899_liver	0.29 RPM	50.25 RPM
ERP005899_muscle	0.48 RPM	66.25 RPM
SRP017611_brain	1.74 RPM	65.69 RPM
SRP017611_kidney	2.07 RPM	77.23 RPM
SRP017611_liver	0.68 RPM	39.42 RPM
SRP030211_testis	16.45 RPM	464.61 RPM

ChIP-Seq

Bos taurus was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_btau_20 retrocopy.

TSS

Bos taurus was not studied using FANTOM5 data.

Lab

retro_btau_20 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_btau_20 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 22 parental genes, and 34 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000014759	1 retrocopy	retro_btau_20 ,
Canis familiaris	ENSCAFG00000012926	2 retrocopies	retro_cfam_1369, retro_cfam_1911,
Callithrix jacchus	ENSCJAG00000021611	1 retrocopy	retro_cjac_1737,
Homo sapiens	ENSG00000084463	2 retrocopies	retro_hsap_1878, retro_hsap_4719,
Gorilla gorilla	ENSGGOG00000004448	3 retrocopies	retro_ggor_1375, retro_ggor_1711, retro_ggor_2932,
Macropus eugenii	ENSMEUG00000013971	1 retrocopy	retro_meug_1952,
Myotis lucifugus	ENSMLUG00000015216	1 retrocopy	retro_mluc_1074,
Macaca mulatta	ENSMMUG00000019299	1 retrocopy	retro_mmul_1329,
Monodelphis domestica	ENSMODG00000017949	1 retrocopy	retro_mdom_143,
Mustela putorius furo	ENSMPUG00000011619	1 retrocopy	retro_mputfur_280,
Mus musculus	ENSMUSG00000030216	1 retrocopy	retro_mmus_2740,
Nomascus leucogenys	ENSNLEG00000003926	1 retrocopy	retro_nleu_2651,
Oryctolagus cuniculus	ENSOCUG00000017177	1 retrocopy	retro_ocun_974,
Otolemur garnettii	ENSOGAG00000010518	1 retrocopy	retro_ogar_207,
Ochotona princeps	ENSOPRG00000015008	3 retrocopies	retro_opri_107, retro_opri_1159, retro_opri_678,
Pongo abelii	ENSPPYG00000004323	3 retrocopies	retro_pabe_1558, retro_pabe_2099, retro_pabe_3663,
Pan troglodytes	ENSPTRG00000004724	3 retrocopies	retro_ptro_1260, retro_ptro_1637, retro_ptro_3136,
Rattus norvegicus	ENSRNOG00000005505	3 retrocopies	retro_rnor_1287, retro_rnor_2726, retro_rnor_741,
Rattus norvegicus	ENSRNOG00000049593	1 retrocopy	retro_rnor_740,
Sorex araneus	ENSSARG00000007085	1 retrocopy	retro_sara_753,
Sarcophilus harrisii	ENSSHAG00000016649	1 retrocopy	retro_shar_81,
Tupaia belangeri	ENSTBEG00000003394	1 retrocopy	retro_tbel_2213,