RetrogeneDB ID: retro_ggor_163

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 13:34319947..34322245(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSGGOG00000034934
• Aliases: None
• Status: KNOWN_PROTEIN_CODING

Parental gene information

• Parental gene symbol: UTP14A
• Ensembl ID: ENSGGOG00000014930
• Aliases: None
• Description: None

Sequence

>retro_ggor_163
ATGAATGTGAACCAGGTTGCGGAGAATCTGGCTTTGAGCCAACAGGAAGAACTAGTGGATTTACCAAAAAACTACCCCTT
GAGTGAGAATGAAGATGGGGACAGTGATGGAGAGAGAAAGCATCAAAAGCTTCTGGAAGCAATCAGTTCCCTTGATGGAA
AGAATAGGCGGAAACTGGCTGAGAGGTCTGAGGCTAGTCTGAAAGTGTCAGAGTTCAGTGTCAGTTCTGAAGGATCAGGA
GAAAAGCTGGTCCTTGCAGATCTGCTTGAGCCCGTTAAAACTTCATCTTCTTTGGCCACTGTAAAAAAGCAACTGAATAG
AGTCAAATCAAAGAAAGTGGTGGAGTCACCTCTTAACAAAGAAAAAATTGAACAGATCCACAGAGAAGTAGCATTCAGTA
AAACCTCACAGGTCCTCTCCAAATGGGACCCTATCATCCTGAAGAACCAGCAGGCAGAGCAGCTGGTTTTTCCCCTGGGG
AAGGAGCAGCCAACCATTGCTCCCATTGAACATGCGCTCAGTGGCTGGCAGGCAAGAACTCCCCTGGAGCAGGAAATTTT
TAACCTCCTCCATAAGAACAAGCAGCCAGTGACAGATCCTTTACTGACTCCCATGGAAAAGGCCTCTCTCCAAGCCATGA
GCCTGGAAGAGGCAAAGATGCACCGAGCAGAGCTTCAGAGGGCTCGGGCTCTGCAGTCCTACTATGAGGCCAAGGCTCGA
AAAGAGAAGAAAATCAAAAGTAAAAAGTATCACAAAGTCGTGAAGAAAGGAAAGGCCAAGAAAGCCTTAAAAGAGTTTGA
GCAGCTACAGAAGGTTAATCCAACTGTGGCACTGGAAGAAATGGAAAAAATTGAAAATGCCAGGATGATGGAAAGAATGA
GCCTTAAGCACCAAAACAGTGGGAAATGGGCCAAGTCAAAGGCAATTATGGCCAAATATGACCTGGAGGCTCGCCAAGCT
ATGCAGGAACAGTTGGCCAAAAACAAAGAACTGACACGGAAACTCCAGGTAGCCTCTGAGAGTGAGGAAGAGGAGGGAGG
CACAGAAGTGGAAGAACTCCTTGTCCCTCATGTAGTGAATGAAGTGCAGATGAATGTGGATGGACCGAATCCCTGGATGT
TCAGGAGCTGCACCAGTGACACCAAAGAGGCTGCAACACAGGAGGACCCTGAGCAACTGCCAGAGCTTGCAGCTCATGAG
GTTTCTGCAAGTGAGGCAGAAGAAAGACCAGTGGCAGAGGAAGAAATTTTGTTGAGAGAATTTGAGGAGAGGCAATCCCT
TAGGAAAAGATCTGAGCTTAACCAGGATGCTGAGCCAGCAAGCAGTCAAGAAACAAAAGATTCTAGCAGCCAGGAGGTGC
TGTCCGAATTGAGGGCACTATCTCAGAAATTGAAGGAAAAACATCAGTCCAGGAAGCAAAAAGCAAGTTCAGAGGGGACT
GTTCCCCAGGTCCAGAGAGAGGAACCTGCCCCAGAAGAAGCGGAACCTCTATTGCTACAGAGGTCAGAGAGAGTACAAAC
TCTGGAAGAGCTAGAAGAGCTGGGAAAAGAAGATTGTTTTCAAAATAAGGAGCTTCCCAGACCTGTGTTAGAAGGACAGC
AGTCAGAGAGGACCCCAAATAATCAGCCTGATGCCCCTAAGGAGAAGAAAGAGAAGGAGCAACTGATCGACCTACAGAAC
TTCCTAACCACACAGTCTCCTTCCATGAGGTCTTTGGCAGTTCCCACAATAATAGAGGAGCTGGAAGATGAAGAGGAGAG
AGACCAAGGGCAGATGATAAAGGAAGCTTTTGCTGGGGATGATGTCATCAGAGATTTCTTGAAAGAGAAGAGGGAAGCTG
TGGAGGCAAGTAAGCCAAAAGACGTGGACCTGACACTACCTGGCTGGGGCGAGTGGGGTGGTGTGGGCCTAAAGCCCAGT
GCCAAGAAAAGACGCCAGTTTCTCATTAAAGCCCCTGAGGGTCCTCCAAGAAAAGATAAGAATTTGCCAAATGTGATTAT
CAGTGAGAAGCGCAACATCCACGCAGCAGCTCATCAGGTACAAGTGCTTCCATATCCATTTACCCACCATCAGCAATTTG
AAAGGACCATCCAGACCCCTATAGGATCCACATGGAACACCCAGAGGGCTTTCCAAAAGCTGACTACTCCCAAGGTCGTC
ACCAAGCCAGGCCATATCATTAAGCCCTTAAAAGCAGAGGATGTGGGCTACCAGTCTTCCTCAAGGTCAGACCTGCCTGT
CATACAGAGGAATCCAAAACGAATCACCACACGTCACAATAAAGAAGAAAAACTGTAG

Alignment

ORF - retro_ggor_163 Open Reading Frame is conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 89.31 %
• Parental protein coverage: 99.35 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  MTANRLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSEASLK
          M..N..AE.L.ALSQQEEL.DLPK.Y.LSE.ED.GD.DGERKHQKLLEAISSLDGKNRRKLAERSEASLK
Retrocopy MNVNQVAENL-ALSQQEELVDLPKNYPLSENED-GDSDGERKHQKLLEAISSLDGKNRRKLAERSEASLK

Parental  VSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPLNKEEIERIHREVAFNKTAQV
          VSEF.VSSEGSGEKLVLADLLEPVKTSSSLATVKKQL.RVKSKK.VE.PLNKE.IE.IHREVAF.KT.QV
Retrocopy VSEFSVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLNRVKSKKVVESPLNKEKIEQIHREVAFSKTSQV

Parental  LSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPVADPLLTPVEKA
          LSKWDP..LKN.QAEQLVFPL.KE.P.IAPIEH.LSGW.ARTPLEQEIFNLLHKNKQPV.DPLLTP.EKA
Retrocopy LSKWDPIILKNQQAEQLVFPLGKEQPTIAPIEHALSGWQARTPLEQEIFNLLHKNKQPVTDPLLTPMEKA

Parental  SLRAMSLEEAKMRRGELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAAL
          SL.AMSLEEAKM.R.ELQRARALQSYYEAKAR.EKKIKSKKYHKVVKKGKAKKALKEFEQL.KVNP..AL
Retrocopy SLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVAL

Parental  EELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGT
          EE.EKIE.ARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL.KNKELT.KLQVASESEEEEGGT
Retrocopy EEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTRKLQVASESEEEEGGT

Parental  EDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEIL
          E.VEELLVP.VVNEVQMN.DGPNPWM.RSCTSDTKEAATQEDPEQLPEL.AH.VS.SE.EERPVAEEEIL
Retrocopy E-VEELLVPHVVNEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQLPELAAHEVSASEAEERPVAEEEIL

Parental  LREFEERRSLRKISELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQRE
          LREFEER.SLRK.SEL.QDAEPA.SQETKDS.SQEVLSELR.LSQKLKE.HQSRKQKASSEGT.PQVQRE
Retrocopy LREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQRE

Parental  EPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMID
          EPAPEE.EPLLLQR.ERVQTLEELEELGKE.CFQNKELPRPVLEGQQSERTPNN.PDAPKEKK.KEQ.ID
Retrocopy EPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNQPDAPKEKKEKEQLID

Parental  LQNLLTTQSPSVKSLAVPT-VEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVDLTLP
          LQN.LTTQSPS..SLAVPT..EELEDEEER...QMIKEAFAGDDVIRDFLKEKREAVEASKPKDVDLTLP
Retrocopy LQNFLTTQSPSMRSLAVPTIIEELEDEEERDQGQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVDLTLP

Parental  GWGEWGGVGLKPSAKKRRRFLIKAPEGPPRKDKNLPNVIINEKRNIHAAAHQVRVLPYPFTHHWQFERTI
          GWGEWGGVGLKPSAKKRR.FLIKAPEGPPRKDKNLPNVII.EKRNIHAAAHQV.VLPYPFTHH.QFERTI
Retrocopy GWGEWGGVGLKPSAKKRRQFLIKAPEGPPRKDKNLPNVIISEKRNIHAAAHQVQVLPYPFTHHQQFERTI

Parental  QTPIGSTWNTQRAFQKLTTPKVVTKPGHIINPIKAEDVGYRSSSRSDLSVIQRNPKRITTRHKKQLK
          QTPIGSTWNTQRAFQKLTTPKVVTKPGHII.P.KAEDVGY.SSSRSDL.VIQRNPKRITTRH.K..K
Retrocopy QTPIGSTWNTQRAFQKLTTPKVVTKPGHIIKPLKAEDVGYQSSSRSDLPVIQRNPKRITTRHNKEEK

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	18.61 RPM	12.42 RPM
SRP007412_cerebellum	14.93 RPM	9.26 RPM
SRP007412_heart	3.72 RPM	3.56 RPM
SRP007412_kidney	16.93 RPM	9.65 RPM
SRP007412_liver	7.04 RPM	5.20 RPM
SRP007412_testis	11.40 RPM	2.80 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_163 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_163 has 2 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_29
Pan troglodytes	retro_ptro_824

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Parental genes homology:

Parental genes homology involve 14 parental genes, and 17 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000013671	2 retrocopies	retro_btau_133, retro_btau_1706,
Cavia porcellus	ENSCPOG00000014231	2 retrocopies	retro_cpor_1272, retro_cpor_242,
Dasypus novemcinctus	ENSDNOG00000002180	1 retrocopy	retro_dnov_1479,
Homo sapiens	ENSG00000156697	1 retrocopy	retro_hsap_29,
Gorilla gorilla	ENSGGOG00000014930	1 retrocopy	retro_ggor_163 ,
Loxodonta africana	ENSLAFG00000016653	1 retrocopy	retro_lafr_110,
Myotis lucifugus	ENSMLUG00000001984	2 retrocopies	retro_mluc_1643, retro_mluc_308,
Macaca mulatta	ENSMMUG00000020700	1 retrocopy	retro_mmul_35,
Mus musculus	ENSMUSG00000063785	1 retrocopy	retro_mmus_261,
Nomascus leucogenys	ENSNLEG00000015258	1 retrocopy	retro_nleu_2091,
Procavia capensis	ENSPCAG00000006070	1 retrocopy	retro_pcap_127,
Pan troglodytes	ENSPTRG00000022262	1 retrocopy	retro_ptro_824,
Tarsius syrichta	ENSTSYG00000009415	1 retrocopy	retro_tsyr_2104,
Tursiops truncatus	ENSTTRG00000003794	1 retrocopy	retro_ttru_1687,