RetrogeneDB ID: retro_ptro_3194

Retrocopy location

• Organism: Chimpanzee (Pan troglodytes)
• Coordinates: X:38743206..38743574(-)
• Located in intron of: ENSPTRG00000021799

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: TDGF1
• Ensembl ID: ENSPTRG00000014854
• Aliases: None
• Description: teratocarcinoma-derived growth factor 1 [Source:HGNC Symbol;Acc:11701]

Sequence

>retro_ptro_3194
TCAGAGTTTGTGCCATCCATGGGGACACAGGACAGTAAGGAACGAAACAGAACCTGCTGTCTAAATGGGGGAACCTGCAT
GCTGGGGTGCTTTTGTGTCTTCCCTTCCTCCTATGGATGGAACTGTGAGCATGTTGTGTGCAGAGAGAGCTGTGGGTCTG
TGCACCATGACATCTGGCTGCCCAAGAAGCGTTCTATGTGTAAATGCTGGCATGGCCAACCCCTCTGCTTTCCTGAGGCA
TTTCTACCTGGTTGTGATGGCCTTGTGATGTTTGAGCACCTCATGGCTCCCAGGACTCTGGAATACTACCATCTGCATGT
ACCACTTTTATGCTAGCTGGCACGTGCCTTTCCATACAAAGTTACTAT

Alignment

ORF - retro_ptro_3194 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 72.22 %
• Parental protein coverage: 66.49 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  SQRVPPMGIQHSKELNRTCCLNGGTCMLGSFCACPPSFYGRNCEHDVRKENCGSVPHDTWLPKKCSLCKC
          S..VP.MG.Q.SKE.NRTCCLNGGTCMLG.FC..P.S.YG.NCEH.V..E.CGSV.HD.WLPKK.S.CKC
Retrocopy SEFVPSMGTQDSKERNRTCCLNGGTCMLGCFCVFPSS-YGWNCEHVVCRESCGSVHHDIWLPKKRSMCKC

Parental  WHGQLRCFPQAFLPGCDGLVMDEHLVASRTPE-LPLSARTTTFMLVGICLSIQSYY
          WHGQ..CFP.AFLPGCDGLVM.EHL.A.RT.E....SA.TT.FML.G.CLSIQSYY
Retrocopy WHGQPLCFPEAFLPGCDGLVMFEHLMAPRTLE<ILPSACTT-FMLAGTCLSIQSYY

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	0.43 RPM
SRP007412_cerebellum	0.00 RPM	0.14 RPM
SRP007412_heart	0.00 RPM	0.03 RPM
SRP007412_kidney	0.00 RPM	1.10 RPM
SRP007412_liver	0.00 RPM	5.70 RPM
SRP007412_testis	0.00 RPM	0.11 RPM

ChIP-Seq

Pan troglodytes was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_ptro_3194 retrocopy.

TSS

Pan troglodytes was not studied using FANTOM5 data.

Lab

retro_ptro_3194 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ptro_3194 has 4 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_4804
Gorilla gorilla	retro_ggor_2990
Macaca mulatta	retro_mmul_2560
Callithrix jacchus	retro_cjac_4151

---

Parental genes homology:

Parental genes homology involve 14 parental genes, and 48 retrocopies.

Species	Parental gene accession	Retrocopies number
Callithrix jacchus	ENSCJAG00000002174	3 retrocopies	retro_cjac_1594, retro_cjac_4151, retro_cjac_938,
Felis catus	ENSFCAG00000014508	1 retrocopy	retro_fcat_714,
Homo sapiens	ENSG00000241186	7 retrocopies	retro_hsap_1999, retro_hsap_2393, retro_hsap_2709, retro_hsap_3415, retro_hsap_3956, retro_hsap_4737, retro_hsap_4804,
Gorilla gorilla	ENSGGOG00000003453	5 retrocopies	retro_ggor_1447, retro_ggor_1815, retro_ggor_2307, retro_ggor_2943, retro_ggor_2990,
Loxodonta africana	ENSLAFG00000009140	4 retrocopies	retro_lafr_1037, retro_lafr_1067, retro_lafr_757, retro_lafr_871,
Microcebus murinus	ENSMICG00000016492	1 retrocopy	retro_mmur_635,
Macaca mulatta	ENSMMUG00000003088	6 retrocopies	retro_mmul_1744, retro_mmul_2290, retro_mmul_2560, retro_mmul_742, retro_mmul_770, retro_mmul_967,
Mustela putorius furo	ENSMPUG00000015167	1 retrocopy	retro_mputfur_961,
Mus musculus	ENSMUSG00000032494	3 retrocopies	retro_mmus_1429, retro_mmus_1544, retro_mmus_1908,
Nomascus leucogenys	ENSNLEG00000006143	6 retrocopies	retro_nleu_1649, retro_nleu_2124, retro_nleu_2179, retro_nleu_2317, retro_nleu_2519, retro_nleu_535,
Otolemur garnettii	ENSOGAG00000017039	1 retrocopy	retro_ogar_2611,
Pan troglodytes	ENSPTRG00000014854	7 retrocopies	retro_ptro_1333, retro_ptro_1749, retro_ptro_1831, retro_ptro_2319, retro_ptro_2685, retro_ptro_3153, retro_ptro_3194 ,
Tarsius syrichta	ENSTSYG00000013609	2 retrocopies	retro_tsyr_295, retro_tsyr_574,
Tursiops truncatus	ENSTTRG00000017299	1 retrocopy	retro_ttru_441,