RetrogeneDB ID: retro_pabe_1290

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 15:39387040..39388113(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: FDPS
• Ensembl ID: ENSPPYG00000000747
• Aliases: None
• Description: farnesyl pyrophosphate synthase [Source:RefSeq peptide;Acc:NP_001125620]

Sequence

>retro_pabe_1290
AAAGCCCTCTGCTCGTCCCTCAGAATGAATGGAGACCAGAGATCAGATGTTTATGTGCAAGAAAAGCAGGATTTCGTTCA
GTGCTTCTCCCAGATCATTGGGGATGAGATGAGGCACCCAGAGACAGGAGATGCTATCACCCAGCGCAAAGAGGTCCTGT
AGTACAATGCCATTGGAGGCAAGTATCACCGGGCTTTGACGGTGCTAGTAGCATTCTGGGAGCTGGTGGAGCTGAGGAAA
CAGGATGCTGAGAGTCTCCAGCGGTCCCTGACTATGGGCTGGTGCGTGGAACTGCTGCAAACTTTGTTCCTGGTGGCAAA
TGACATCACGGATTCATTGCTCACCGCTGGGAACAGATCTGCTGGTTTCAGAAGCCGGGCGTGGGTTTGGATGCCATCAG
TGATGCTATCCTTGTGGAAGCATGTATCTACCGCCTGCTGAAGCTCTATTGCTGGGAGCCAGCCCTATTGCCAGAACCTG
ATCCAGCTCTTCCTGCAGAGTTTATATCAGACTGAGATTGGGCAGACCCTGGACCTCATCACAGCCCCCCAGGGCAATGC
GGATCTTGGCAGATTCACTGAAAAGAGGTACAAATCCAGCGTCAAGTACAAGGCAGTTTCTACTCCTTCTACCTTCCTGT
AGCTGCAGCCATGTACATGGCAGGTATTGATAGAGAGAAGGAGCATACCAATACCAAGAAGATCCTGCTGGAGATGGGAG
AGGGAGAGTTCTTTCAGATCAGGATGATTACCTTCACCTCTTTTGGGGACCCCAGTGTGACCAGCAAAGTTGGCACTGAC
ATCCAGGACAACAAATGCAGCTGGCTGGTGGTTCAGTGTCTGCAACGGGCCACTCCAGAACAGTACCAGATCCTGAAGGA
GAATTACAGGCAGAAGGAGGCCAAGAAGGTGGCCCAGGTGAAGGCACTATATGAGGAGCTGGATCTGCCGGCTGTGTTCT
TGCAATAATAGGAAGACAGTTACAGCCACATTATGGGTCTCATTGAACAGTACACAGCTCCCGTGTCCCCAGCCATCTTT
CTAGGGCTGACATGCAAAATCTACAAGCGTAAA

Alignment

ORF - retro_pabe_1290 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 79.84 %
• Parental protein coverage: 81.92 %
• Number of stop codons detected: 3
• Number of frameshifts detected: 5

Retrocopy - Parental Gene Alignment:

Parental  RALCSSLRMNGDQKSDVYAQEKQDFVQHFSQIVRMLTEDEMGHPETGDAIARLKEVLEYNAIGGKYHRGL
          .ALCSSLRMNGDQ.SDVY.QEKQDFVQ.FSQ.......DEM.HPETGDAI...KEVL.YNAIGGKYHR.L
Retrocopy KALCSSLRMNGDQRSDVYVQEKQDFVQCFSQ----IIGDEMRHPETGDAITQRKEVL*YNAIGGKYHRAL

Parental  TVVVAFRELVQPRKQDADSLQRARTVGWCVELV--FFLVADDIMDSSLT-RRGQICWYQKPGVGLDAIND
          TV.VAF.ELV..RKQDA.SLQR..T.GWCVEL....FLVA.DI.DS.LT.R..QICW.QKPGVGLDAI.D
Retrocopy TVLVAFWELVELRKQDAESLQRSLTMGWCVELLQTLFLVANDITDSLLT<RWEQICWFQKPGVGLDAISD

Parental  ANLLEACIYRLLKLYCRE-QPYYLNLIELFLQSSYQTEIGQTLDLITAPQGNVDLVRFTEKRYKSIVKYK
          A.L.EACIYRLLKLYC.E.QPY..NLI.LFLQS.YQTEIGQTLDLITAPQGN.DL.RFTEKRYKS.VKYK
Retrocopy AILVEACIYRLLKLYCWE>QPYCQNLIQLFLQSLYQTEIGQTLDLITAPQGNADLGRFTEKRYKSSVKYK

Parental  T-AFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGE--FFQI-QDDYLDLF-GDPSVTGKIGTDIQDN
          ...FYSFYLP.AAAMYMAGID.EKEH.N.KKILLEMGE..FFQI.QDDYL.LF.GDPSVT.K.GTDIQDN
Retrocopy A<SFYSFYLPVAAAMYMAGIDREKEHTNTKKILLEMGEGEFFQI<QDDYLHLF>GDPSVTSKVGTDIQDN

Parental  KCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAP
          KCSWLVVQCLQRATPEQYQILKENY.QKEA.KVA.VKALYEELDLPAVFLQ..EDSYSHIM.LIEQY.AP
Retrocopy KCSWLVVQCLQRATPEQYQILKENYRQKEAKKVAQVKALYEELDLPAVFLQ**EDSYSHIMGLIEQYTAP

Parental  LPPAIFLGLARKIYKRR
          ..PAIFLGL..KIYKR.
Retrocopy VSPAIFLGLTCKIYKRK

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.33 RPM	44.23 RPM
SRP007412_cerebellum	0.00 RPM	34.53 RPM
SRP007412_heart	0.00 RPM	10.08 RPM
SRP007412_kidney	0.00 RPM	36.16 RPM
SRP007412_liver	0.03 RPM	75.10 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_1290 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_1290 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_1290 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_1558
Pan troglodytes	retro_ptro_1048
Gorilla gorilla	retro_ggor_1184

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Parental genes homology:

Parental genes homology involve 13 parental genes, and 57 retrocopies.

Species	Parental gene accession	Retrocopies number
Canis familiaris	ENSCAFG00000030749	2 retrocopies	retro_cfam_1822, retro_cfam_1888,
Callithrix jacchus	ENSCJAG00000008364	11 retrocopies	retro_cjac_1066, retro_cjac_1217, retro_cjac_1395, retro_cjac_157, retro_cjac_2011, retro_cjac_2081, retro_cjac_2161, retro_cjac_299, retro_cjac_4154, retro_cjac_44, retro_cjac_70,
Echinops telfairi	ENSETEG00000001154	6 retrocopies	retro_etel_1770, retro_etel_1818, retro_etel_2179, retro_etel_730, retro_etel_743, retro_etel_990,
Homo sapiens	ENSG00000160752	6 retrocopies	retro_hsap_1519, retro_hsap_1558, retro_hsap_1560, retro_hsap_3871, retro_hsap_3872, retro_hsap_502,
Microcebus murinus	ENSMICG00000007468	1 retrocopy	retro_mmur_1148,
Macaca mulatta	ENSMMUG00000023144	3 retrocopies	retro_mmul_1190, retro_mmul_2152, retro_mmul_565,
Mus musculus	ENSMUSG00000059743	5 retrocopies	retro_mmus_1028, retro_mmus_1552, retro_mmus_2802, retro_mmus_3625, retro_mmus_590,
Nomascus leucogenys	ENSNLEG00000012099	6 retrocopies	retro_nleu_1486, retro_nleu_1727, retro_nleu_2301, retro_nleu_2405, retro_nleu_2595, retro_nleu_2692,
Pongo abelii	ENSPPYG00000000747	3 retrocopies	retro_pabe_1290 , retro_pabe_1329, retro_pabe_235,
Pan troglodytes	ENSPTRG00000001422	9 retrocopies	retro_ptro_1028, retro_ptro_1048, retro_ptro_1049, retro_ptro_2637, retro_ptro_2638, retro_ptro_2639, retro_ptro_2940, retro_ptro_2995, retro_ptro_377,
Rattus norvegicus	ENSRNOG00000043377	3 retrocopies	retro_rnor_1175, retro_rnor_153, retro_rnor_2897,
Ictidomys tridecemlineatus	ENSSTOG00000004475	1 retrocopy	retro_itri_488,
Tursiops truncatus	ENSTTRG00000013326	1 retrocopy	retro_ttru_689,