RetrogeneDB ID: retro_ogar_3266

Retrocopy location

• Organism: Bushbaby (Otolemur garnettii)
• Coordinates: GL873758.1:944290..945126(-)
• Located in intron of: ENSOGAG00000032555

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: MMADHC
• Ensembl ID: ENSOGAG00000034385
• Aliases: None
• Description: methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria [Source:HGNC Symbol;Acc:25221]

Sequence

>retro_ogar_3266
GTGCTTTGTAGCAGAGCCAGACTGTATCTCCCAGGGCTTTGCTCTTCAGTTAAAAGGGTTGTCAATCCCAAAACTTTTTC
AACTGTGGGATCATTAGGTTCTGATGAGTCTCATGTAGCCAATACACCTCTAGATATATGCTCTTGAACAGTGTGGTCTA
ATGAAACTATGGGACTGTTTGTACCTTAGGATCAGAGATTCTAGCTTCCTGGGAACATAGGTTTTGATTGTTACCTTAAT
GGGACCGCTTCACAGAAGAAAAGCCTGGTTCATAAAACTTTGCCTGATGTTCTAATAGAACCTTTATAAAGTTGAGAGAC
ATGAGCTTGTGATGGCATAATATGTAAATGAATTCCAAGGTAATGATGTACCTGTCTAACAAGAAATTAGCAGTGAAGAA
ACTTACTTAGAAAGTGCCATAGTAGAGTGTGTAATCCAGACATGTCCAGAATTGCTGTGAAGAGATTTTGAATCACTATT
TCCAGAAGTAGCTAACAGCAAACTAATGATTCTGACTGTAACACAGAAGATTAAACAGGACATAACTGTTTAGAGTGAAG
AGGTAGAAACTGAAAGAGAAATGCTCTTAGGAAAGTTCATCAGCAGTGTTAAGGAAATTTGCTGTGCTCTTCAAGCTAAA
GGTTACTGGGCTGACTTCAATGACCCATCATCAGGTTTGGTATTTTTTGGACCATGTACAAAACAACACTCTTTTTGAAA
CAGATGAACGCTACCAATAAGTATTCTCTGTCAATGATCTTGGATGCTGTAAAGTGATTTGTCAGAGTCTCTGGGGTACC
CATGTATTTGAAGGAAGTATCTTCACTAATGCAACA

Alignment

ORF - retro_ogar_3266 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 79.15 %
• Parental protein coverage: 95.9 %
• Number of stop codons detected: 9
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  VFCNRARLVSYLPGFCSLVKRVVSPKAFSTAGSSGSDESHVATAPPDICSRTVWPDETMGPFGPQDQRFQ
          V.C.RARL..YLPG.CS.VKRVV.PK.FST.GS.GSDESHVA..P.DICS.TVW..ETMG.F.P.DQRF.
Retrocopy VLCSRARL--YLPGLCSSVKRVVNPKTFSTVGSLGSDESHVANTPLDICS*TVWSNETMGLFVP*DQRF*

Parental  LPGNIGFDCHLNGTASQKKSLVHKTLPDVLAEPLSS-ERHEFVMAQYVNEFQGNVAPVEQEINSAETYFE
          LPGNIGFDC.LNGTASQKKSLVHKTLPDVL.EPL.S.ERHE.VMA.YVNEFQGN..PV.QEI.S.ETY.E
Retrocopy LPGNIGFDCYLNGTASQKKSLVHKTLPDVLIEPL*S>ERHELVMA*YVNEFQGNDVPV*QEISSEETYLE

Parental  SARVECAIQTCPELLRRDFESLFPEVVNNKLMILTVTQKTKNDMTVWSEEVETEREMLLEKFISGAKEIC
          SA.VEC.IQTCPELL.RDFESLFPEV.N.KLMILTVTQK.K.D.TV.SEEVETEREMLL.KFIS..KEIC
Retrocopy SAIVECVIQTCPELL*RDFESLFPEVANSKLMILTVTQKIKQDITV*SEEVETEREMLLGKFISSVKEIC

Parental  YALRAEGYWADFIDPSSGLAFFGPYT-NNTLFETDERYRHLGFSVDDLGCCKVIRHSLWGTHVFVGSIFT
          .AL.A.GYWADF.DPSSGL.FFGP.T.NNTLFETDERY....FSV.DLGCCKVI..SLWGTHVF.GSIFT
Retrocopy CALQAKGYWADFNDPSSGLVFFGPCT>NNTLFETDERYQ*V-FSVNDLGCCKVICQSLWGTHVFEGSIFT

Parental  NAT
          NAT
Retrocopy NAT

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Otolemur garnettii was not studied using RNA-Seq expression data.

ChIP-Seq

Otolemur garnettii was not studied using ChIP-Seq data.

EST

Otolemur garnettii was not studied using EST data.

TSS

Otolemur garnettii was not studied using FANTOM5 data.

Lab

retro_ogar_3266 was not experimentally validated.

Homology

Retrocopy orthology:

Otolemur garnettii does not belong to any of the species groups (eutheria, teleost or neognath), studied for retrocopy-based homology. For more information about studied groups, please go to help section.

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Parental genes homology:

Parental genes homology involve 12 parental genes, and 19 retrocopies.

Species	Parental gene accession	Retrocopies number
Callithrix jacchus	ENSCJAG00000003086	2 retrocopies	retro_cjac_4082, retro_cjac_4101,
Cavia porcellus	ENSCPOG00000007690	1 retrocopy	retro_cpor_30,
Homo sapiens	ENSG00000168288	2 retrocopies	retro_hsap_4716, retro_hsap_865,
Gorilla gorilla	ENSGGOG00000027348	1 retrocopy	retro_ggor_704,
Macaca mulatta	ENSMMUG00000005633	1 retrocopy	retro_mmul_1058,
Monodelphis domestica	ENSMODG00000003566	2 retrocopies	retro_mdom_1749, retro_mdom_620,
Mustela putorius furo	ENSMPUG00000000323	1 retrocopy	retro_mputfur_1253,
Nomascus leucogenys	ENSNLEG00000010795	2 retrocopies	retro_nleu_1988, retro_nleu_426,
Otolemur garnettii	ENSOGAG00000034385	4 retrocopies	retro_ogar_3266 , retro_ogar_356, retro_ogar_688, retro_ogar_813,
Pan troglodytes	ENSPTRG00000012525	1 retrocopy	retro_ptro_599,
Ictidomys tridecemlineatus	ENSSTOG00000021576	1 retrocopy	retro_itri_1809,
Tarsius syrichta	ENSTSYG00000009075	1 retrocopy	retro_tsyr_1690,