RetrogeneDB ID: retro_cfam_912

Retrocopy location

• Organism: Dog (Canis familiaris)
• Coordinates: 2:84120944..84121196(+)
• Located in intron of: ENSCAFG00000016397

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: GTF2A2
• Ensembl ID: ENSCAFG00000016665
• Aliases: None
• Description: general transcription factor IIA, 2, 12kDa [Source:HGNC Symbol;Acc:4647]

Sequence

>retro_cfam_912
ATGACATATCAGTTATATAGAAATACCACTTTGGGAAACAGTCTCCAAGAGAGCCTTGATGAGCTCATACAATCTCAACA
GATCACCCCCCAACTTGCCCTTAAAGTTCTCCTTCAGTTTGATAAAGCTATAATTCAGCATTGGCGCAGAGGGTTAGGAA
CAGTCAATTTCAGGGGCTCTCTAAATACAAACAGATTCTGCAATAACGTGTGGACTTTTGTATTGAATGATGTTGAATTC
AGAGAGGTGACA

Alignment

ORF - retro_cfam_912 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 88.51 %
• Parental protein coverage: 77.98 %
• Number of stop codons detected: 0
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAI-NSALAQRVRNRVNFRG-SLNTYRFC
          M.YQLYRNTTLGNSLQESLDELIQSQQITPQLAL.VLLQFDKAI.NSALAQRVRN...F.G.SLNT.RFC
Retrocopy MTYQLYRNTTLGNSLQESLDELIQSQQITPQLALKVLLQFDKAI<NSALAQRVRNS-QFQG>SLNTNRFC

Parental  DNVWTFVLNDVEFREVT
          .NVWTFVLNDVEFREVT
Retrocopy NNVWTFVLNDVEFREVT

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP012049_cerebellum	0.00 RPM	19.99 RPM
SRP017611_brain	0.00 RPM	7.70 RPM
SRP017611_kidney	0.00 RPM	17.63 RPM
SRP017611_liver	0.00 RPM	5.44 RPM

ChIP-Seq

Canis familiaris was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_cfam_912 retrocopy.

TSS

Canis familiaris was not studied using FANTOM5 data.

Lab

retro_cfam_912 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_cfam_912 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 16 parental genes, and 33 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000010298	1 retrocopy	retro_btau_1649,
Canis familiaris	ENSCAFG00000016665	2 retrocopies	retro_cfam_786, retro_cfam_912 ,
Cavia porcellus	ENSCPOG00000000816	1 retrocopy	retro_cpor_525,
Dipodomys ordii	ENSDORG00000007867	3 retrocopies	retro_dord_377, retro_dord_385, retro_dord_695,
Homo sapiens	ENSG00000140307	1 retrocopy	retro_hsap_4034,
Macaca mulatta	ENSMMUG00000018428	1 retrocopy	retro_mmul_2303,
Monodelphis domestica	ENSMODG00000011636	1 retrocopy	retro_mdom_1563,
Otolemur garnettii	ENSOGAG00000007061	1 retrocopy	retro_ogar_1752,
Ochotona princeps	ENSOPRG00000012841	1 retrocopy	retro_opri_908,
Pan troglodytes	ENSPTRG00000007129	1 retrocopy	retro_ptro_2734,
Rattus norvegicus	ENSRNOG00000011062	2 retrocopies	retro_rnor_1021, retro_rnor_1141,
Sorex araneus	ENSSARG00000012228	2 retrocopies	retro_sara_607, retro_sara_734,
Sus scrofa	ENSSSCG00000004583	3 retrocopies	retro_sscr_545, retro_sscr_934, retro_sscr_935,
Ictidomys tridecemlineatus	ENSSTOG00000004010	3 retrocopies	retro_itri_1631, retro_itri_440, retro_itri_925,
Tupaia belangeri	ENSTBEG00000001053	9 retrocopies	retro_tbel_1162, retro_tbel_1207, retro_tbel_123, retro_tbel_1394, retro_tbel_1439, retro_tbel_257, retro_tbel_2655, retro_tbel_2737, retro_tbel_513,
Xenopus tropicalis	ENSXETG00000022002	1 retrocopy	retro_xtro_18,