RetrogeneDB ID: retro_mmus_2486

Retrocopy location

• Organism: Mouse (Mus musculus)
• Coordinates: 4:98146146..98146621(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: ENSMUSG00000081096
• Aliases: None
• Status: KNOWN_PSEUDOGENE

Parental gene information

• Parental gene symbol: Rps11
• Ensembl ID: ENSMUSG00000003429
• Aliases: None
• Description: ribosomal protein S11 [Source:MGI Symbol;Acc:MGI:1351329]

Sequence

>retro_mmus_2486
ATGGTGGACATTCAGACAGAGCATGCTTACCAAATGTAGCGTACAATCTTTCAAAAACAAGAAGCATGTTCTGCTGGGAA
AAATTGGCAAACATAAACTCCCTCAGTACTACAAAAACATTCATCTAGGCTTCACGATGCCCAAGGAAGCCATCAAGAGT
ATCTACATAGACAAGAAATGCCTCTTCACTGGTAATGTCTCCATCTGAGGTCAGTTCCTGATTGGTGTTGTGATGAAGAT
GAAGATGCAGAGGACCATTATCATCCACTGGAACTATCTCTATTACATCAGAAAGTACAATCACTTTGAGAAGAGTCACA
AGAACATGTCTGTGCACCTGTCCCCCTGTTTTAGGGATGTACAGACTGGAGACATTGTCACTGTTGGAAAATGCAGGCCC
TTGAGCAAGATGGTTAGAGTCAATGAGCTCAAGGTCACCAAGGCTGCTGGCCCCAAGAAGCAGTTTCAGAAGTTC

Alignment

ORF - retro_mmus_2486 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 77.36 %
• Parental protein coverage: 100.0 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  MADIQTERAYQKQPTIFQ-NKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAIEGTYIDKKCPFTGNVSIR
          M.DIQTE.AYQ...TIFQ.NKK.VLLG..GK.KLP.YYKNI.LGF..PKEAI...YIDKKC.FTGNVSI.
Retrocopy MVDIQTEHAYQM*RTIFQ>NKKHVLLGKIGKHKLPQYYKNIHLGFTMPKEAIKSIYIDKKCLFTGNVSI*

Parental  GRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQIGDIVTVGECRPLSKTVR
          G..L.GVV.KMKMQRTI.I...YL.YIRKYN.FEK.HKNMSVHLSPCFRDVQ.GDIVTVG.CRPLSK.VR
Retrocopy GQFLIGVVMKMKMQRTIIIHWNYLYYIRKYNHFEKSHKNMSVHLSPCFRDVQTGDIVTVGKCRPLSKMVR

Parental  FNVLKVTKAAGTKKQFQKF
          .N.LKVTKAAG.KKQFQKF
Retrocopy VNELKVTKAAGPKKQFQKF

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	0.14 RPM	79.81 RPM
SRP007412_cerebellum	0.04 RPM	69.13 RPM
SRP007412_heart	0.19 RPM	118.45 RPM
SRP007412_kidney	0.12 RPM	111.74 RPM
SRP007412_liver	0.05 RPM	98.26 RPM
SRP007412_testis	0.00 RPM	77.71 RPM

ChIP-Seq

RNA Polymerase II activity near the 5' end of retro_mmus_2486 was not detected

EST

No EST(s) were mapped for retro_mmus_2486 retrocopy.

TSS

No TSS is located nearby retro_mmus_2486 retrocopy 5' end.

Lab

retro_mmus_2486 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmus_2486 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 13 parental genes, and 100 retrocopies.

Species	Parental gene accession	Retrocopies number
Canis familiaris	ENSCAFG00000003631	9 retrocopies	retro_cfam_126, retro_cfam_1333, retro_cfam_1572, retro_cfam_1656, retro_cfam_1669, retro_cfam_1900, retro_cfam_1955, retro_cfam_2121, retro_cfam_248,
Danio rerio	ENSDARG00000053058	1 retrocopy	retro_drer_15,
Dipodomys ordii	ENSDORG00000012195	1 retrocopy	retro_dord_635,
Equus caballus	ENSECAG00000000370	1 retrocopy	retro_ecab_868,
Felis catus	ENSFCAG00000009196	13 retrocopies	retro_fcat_1362, retro_fcat_1491, retro_fcat_1535, retro_fcat_1564, retro_fcat_1719, retro_fcat_1945, retro_fcat_197, retro_fcat_1991, retro_fcat_273, retro_fcat_507, retro_fcat_792, retro_fcat_854, retro_fcat_995,
Microcebus murinus	ENSMICG00000002542	8 retrocopies	retro_mmur_1278, retro_mmur_1317, retro_mmur_186, retro_mmur_295, retro_mmur_430, retro_mmur_452, retro_mmur_812, retro_mmur_820,
Monodelphis domestica	ENSMODG00000013434	7 retrocopies	retro_mdom_1185, retro_mdom_1284, retro_mdom_1421, retro_mdom_1950, retro_mdom_636, retro_mdom_922, retro_mdom_978,
Mus musculus	ENSMUSG00000003429	16 retrocopies	retro_mmus_1738, retro_mmus_2230, retro_mmus_2255, retro_mmus_2322, retro_mmus_2486 , retro_mmus_2854, retro_mmus_3048, retro_mmus_3051, retro_mmus_3060, retro_mmus_3342, retro_mmus_398, retro_mmus_404, retro_mmus_714, retro_mmus_754, retro_mmus_842, retro_mmus_860,
Otolemur garnettii	ENSOGAG00000004627	7 retrocopies	retro_ogar_1290, retro_ogar_1813, retro_ogar_1910, retro_ogar_2037, retro_ogar_2573, retro_ogar_2640, retro_ogar_840,
Pan troglodytes	ENSPTRG00000011299	1 retrocopy	retro_ptro_88,
Rattus norvegicus	ENSRNOG00000020595	18 retrocopies	retro_rnor_1132, retro_rnor_1159, retro_rnor_1261, retro_rnor_1299, retro_rnor_1363, retro_rnor_1414, retro_rnor_1435, retro_rnor_1451, retro_rnor_1635, retro_rnor_1790, retro_rnor_2000, retro_rnor_2647, retro_rnor_385, retro_rnor_394, retro_rnor_538, retro_rnor_737, retro_rnor_835, retro_rnor_989,
Ictidomys tridecemlineatus	ENSSTOG00000023443	2 retrocopies	retro_itri_1033, retro_itri_805,
Tupaia belangeri	ENSTBEG00000016677	16 retrocopies	retro_tbel_125, retro_tbel_1361, retro_tbel_1753, retro_tbel_2071, retro_tbel_2207, retro_tbel_2808, retro_tbel_2947, retro_tbel_319, retro_tbel_3401, retro_tbel_3571, retro_tbel_3600, retro_tbel_3742, retro_tbel_449, retro_tbel_604, retro_tbel_801, retro_tbel_836,