RetrogeneDB ID: retro_ggor_774

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 12:9695760..9696685(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: GOT2
• Ensembl ID: ENSGGOG00000005767
• Aliases: None
• Description: Aspartate aminotransferase [Source:UniProtKB/TrEMBL;Acc:G3QSK6]

Sequence

>retro_ggor_774
ATGGCCCTGCTGCACTCTGGCCGCGTCCTCTCTGGGATCGCTGCCACCTTCCACCTGGGCCTCGCAGCTGCGGCCTCTGC
CAGAGCCAGCTCCTGATGGACCCATGTGGAAATGGGACCTCCAGATATCATCCTGGGAGTCATTGAAAACTTTAAGAGGG
ACACCAATAGCAAAAAGATGAATCTGGGAGTTGGTGCCTACTGGGATGATAACGGAAAGCCTTGGACGTGCTGCCTAGCG
TCCCCAAGGCAGAGGCCCAGATTGCCACAAAAAGTTTGGACAAGGAATACCTGTCCATTGGGGGACTGGCTGAATTTTGC
AAGGCATCTGCAGAACTAGCCCTTGGTGAGAACAGTGAAGTCTTGAAAAGTGGCCGGTTTGTCACTGTGCAGACCATTTC
TGGAACTGGAGCCTTAAGGATTGGAGCCAGCTTTCTGCAAATATTTTTTAAGTTCAGCTGAGATGTCTTTCTGCCCAAAC
CAAGCTGGGGAAATCACACGCCCATCTTCAGGGACACTGGCATGCAGCTACAAGGTTATCGGCTTTATGACCGCAAGAGT
TGCGGTTTTGACTTCACAGGCGCTGTGGAGGGCCTTTCAAAAATACCAGAGCAAAATGTTGTTCTTCTGCATGCCTGCAC
CCACAATCCCATGGGAGTGGACCCACGTCTGGAGCAGTGGAAGGATACAGCAATAATGGTGAAGAAGAAGAGTCTCTTTG
CCTTCTTTGACATGGCCTACCAAGGCTTTACCAGTGGTGATGGTGATAAGGATGCCCGGGCTGTGCACCACTTCATTGAA
CAGGGCATTAATGTTTGTCTCTGCCAATCATATGCCAAGAACATGGGCTTATATGGTGAACGTGTAGGAGCCTTCACTGT
AGTATGCAAAGATGAGATGAAACCAAAAGTGTAGAGTCACAGTTG

Alignment

ORF - retro_ggor_774 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 80.77 %
• Parental protein coverage: 71.63 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDD
          MALLHSGRVL.GIAA.FH.GLAAAASARASS.WTHVEMGPPD.ILGV.E.FKRDTNSKKMNLGVGAY.DD
Retrocopy MALLHSGRVLSGIAATFHLGLAAAASARASS*WTHVEMGPPDIILGVIENFKRDTNSKKMNLGVGAYWDD

Parental  NGKPYV--LPSVRKAEAQIAAKNLDKEYLPIG-GLAEFCKASAELALGENSEVLKSGRFVTVQTISGTGA
          NGKP....L.S.R........K.......P.G.GLAEFCKASAELALGENSEVLKSGRFVTVQTISGTGA
Retrocopy NGKPWTCCLASPRQ-RPRLPQKVWTRNTCPLG<GLAEFCKASAELALGENSEVLKSGRFVTVQTISGTGA

Parental  LRIGASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFTGAVEDISKIPEQSVL
          LRIGASFLQ.FFKFS.DVFLPKP.WGNHTPIFRD.GMQLQGYR.YD.K.CGFDFTGAVE..SKIPEQ.V.
Retrocopy LRIGASFLQIFFKFS*DVFLPKPSWGNHTPIFRDTGMQLQGYRLYDRKSCGFDFTGAVEGLSKIPEQNVV

Parental  ILHACAHNPTGVDPRPEQWKEIATVVKKRNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSY
          .LHAC.HNP.GVDPR.EQWK..A..VKK..LFAFFDMAYQGF.SGDGDKDA.AV.HFIEQGINVCLCQSY
Retrocopy LLHACTHNPMGVDPRLEQWKDTAIMVKKKSLFAFFDMAYQGFTSGDGDKDARAVHHFIEQGINVCLCQSY

Parental  AKNMGLYGERVGAFTMVCKDA-DEAKRVESQL
          AKNMGLYGERVGAFT.VCKD..DE.K.VESQL
Retrocopy AKNMGLYGERVGAFTVVCKDE<DETKSVESQL

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	135.85 RPM
SRP007412_cerebellum	0.00 RPM	78.64 RPM
SRP007412_heart	0.00 RPM	210.01 RPM
SRP007412_kidney	0.04 RPM	123.16 RPM
SRP007412_liver	0.05 RPM	271.77 RPM
SRP007412_testis	0.31 RPM	78.94 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_774 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_774 has 2 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_960
Pan troglodytes	retro_ptro_665

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Parental genes homology:

Parental genes homology involve 18 parental genes, and 34 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000017346	3 retrocopies	retro_amel_1805, retro_amel_815, retro_amel_846,
Canis familiaris	ENSCAFG00000008357	2 retrocopies	retro_cfam_586, retro_cfam_816,
Callithrix jacchus	ENSCJAG00000011234	1 retrocopy	retro_cjac_2916,
Equus caballus	ENSECAG00000016504	1 retrocopy	retro_ecab_694,
Felis catus	ENSFCAG00000025552	3 retrocopies	retro_fcat_1068, retro_fcat_1888, retro_fcat_381,
Homo sapiens	ENSG00000125166	4 retrocopies	retro_hsap_4687, retro_hsap_473, retro_hsap_960, retro_hsap_971,
Gorilla gorilla	ENSGGOG00000005767	3 retrocopies	retro_ggor_2912, retro_ggor_449, retro_ggor_774 ,
Macropus eugenii	ENSMEUG00000012574	1 retrocopy	retro_meug_2109,
Microcebus murinus	ENSMICG00000008954	1 retrocopy	retro_mmur_480,
Macaca mulatta	ENSMMUG00000006000	1 retrocopy	retro_mmul_1337,
Mustela putorius furo	ENSMPUG00000004862	1 retrocopy	retro_mputfur_567,
Mus musculus	ENSMUSG00000031672	1 retrocopy	retro_mmus_2701,
Oryctolagus cuniculus	ENSOCUG00000003871	1 retrocopy	retro_ocun_1516,
Otolemur garnettii	ENSOGAG00000000551	2 retrocopies	retro_ogar_2182, retro_ogar_827,
Pongo abelii	ENSPPYG00000007413	3 retrocopies	retro_pabe_3640, retro_pabe_823, retro_pabe_901,
Pan troglodytes	ENSPTRG00000008185	4 retrocopies	retro_ptro_3115, retro_ptro_354, retro_ptro_665, retro_ptro_670,
Rattus norvegicus	ENSRNOG00000011782	1 retrocopy	retro_rnor_2695,
Tupaia belangeri	ENSTBEG00000001808	1 retrocopy	retro_tbel_3799,