RetrogeneDB ID: retro_pabe_3212

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 7_random:17016006..17016627(+)
• Located in intron of: ENSPPYG00000025938

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: STRAP
• Ensembl ID: ENSPPYG00000004334
• Aliases: None
• Description: serine/threonine kinase receptor associated protein [Source:HGNC Symbol;Acc:30796]

Sequence

>retro_pabe_3212
AAAGTGTGGGATGCTATCCCAGGAGATGAACTGATGACCCTGGCTCATAAACACATTATCAAGACTACGGATTTCATGCA
GGATAGTAATTATTTGTTAACCAGGGGACAGGATAAACCGTTTTGCATATATGACTTGAACAAACCTGAAGCAGAACCTG
AGGAAATTACTGATCACAGCTCTGATATAAAAAAGGCCCTATGGTGCAGTAAAGATAAACAGATTCTTTCTTCTGATGAC
AAAACTGTTAGACTTTGGGATCATGCTACTATGACAGAAGTGAAATCTCTAAATTTTATTATGTTGGCTAGTAGTATGGA
ATATATTCCTGAGGGAGAGATTTTGATAATAACTTATGGCTGATCCAGTGCTTTTGACAGTACAGTAAGTTTGGAACCAA
TTAAATCCTTTCAAGCTCCTGCAACCATTAACTCTGAATCTCTTCACCTTGAGAAAGATTTTCTTGTTGCAGGTGGTGAA
GATGTTAAACTTATAAGTAAGATGATAATAGTGGAGAAGAATCAGAATCCTATAAAGGGCACTCCGGTCCCATTCACTGT
GAGATTTGATCCTGATGGAGAACTCTATGCCAGTGGTTCTGAAGATGGAATACTGAGACTG

Alignment

ORF - retro_pabe_3212 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 79.52 %
• Parental protein coverage: 59.43 %
• Number of stop codons detected: 2
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  KVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCS
          KVWDA..GDELMTLAHKHI.KT.DF.QDSNYLLT.GQDK...IYDLNKPEAEP.EI..H.S.IKKALWCS
Retrocopy KVWDAIPGDELMTLAHKHIIKTTDFMQDSNYLLTRGQDKPFCIYDLNKPEAEPEEITDHSSDIKKALWCS

Parental  EDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAP
          .DKQILS.DDKTVRLWDHATMTEVKSLNF.M..SSMEYIPEGEIL.ITYG.S.AF.S.VSL.PIKSF.AP
Retrocopy KDKQILSSDDKTVRLWDHATMTEVKSLNFIMLASSMEYIPEGEILIITYG*SSAFDSTVSLEPIKSFQAP

Parental  ATINSASLHPEKEFLVAGGEDFKL-YKYDYNSGEELESY-KGHFGPIHCVRFSPDGELYASGSEDGTLRL
          ATINS.SLH.EK.FLVAGGED.KL.YK.D.NSGEE.ESY.KG...P...VRF.PDGELYASGSEDG.LRL
Retrocopy ATINSESLHLEKDFLVAGGEDVKL<YK*DDNSGEESESY>KGTPVPF-TVRFDPDGELYASGSEDGILRL

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.06 RPM	53.91 RPM
SRP007412_cerebellum	0.00 RPM	38.91 RPM
SRP007412_heart	0.00 RPM	32.03 RPM
SRP007412_kidney	0.03 RPM	35.73 RPM
SRP007412_liver	0.03 RPM	37.30 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_3212 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_3212 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_3212 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 12 parental genes, and 23 retrocopies.

Species	Parental gene accession	Retrocopies number
Choloepus hoffmanni	ENSCHOG00000007422	2 retrocopies	retro_chof_1098, retro_chof_1620,
Callithrix jacchus	ENSCJAG00000021593	1 retrocopy	retro_cjac_2503,
Homo sapiens	ENSG00000023734	2 retrocopies	retro_hsap_2092, retro_hsap_3723,
Gorilla gorilla	ENSGGOG00000009939	1 retrocopy	retro_ggor_1633,
Macaca mulatta	ENSMMUG00000013307	2 retrocopies	retro_mmul_1695, retro_mmul_985,
Mus musculus	ENSMUSG00000030224	1 retrocopy	retro_mmus_794,
Nomascus leucogenys	ENSNLEG00000004160	2 retrocopies	retro_nleu_1301, retro_nleu_1970,
Ochotona princeps	ENSOPRG00000015211	3 retrocopies	retro_opri_1029, retro_opri_217, retro_opri_541,
Pongo abelii	ENSPPYG00000001598	2 retrocopies	retro_pabe_3169, retro_pabe_3175,
Pongo abelii	ENSPPYG00000004334	3 retrocopies	retro_pabe_2005, retro_pabe_3134, retro_pabe_3212 ,
Pan troglodytes	ENSPTRG00000004734	2 retrocopies	retro_ptro_1538, retro_ptro_2616,
Tursiops truncatus	ENSTTRG00000003466	2 retrocopies	retro_ttru_581, retro_ttru_974,