RetrogeneDB ID: retro_pabe_1473

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 17:1458446..1458667(-)
• Located in intron of: ENSPPYG00000007774

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: TMEM14C
• Ensembl ID: ENSPPYG00000016225
• Aliases: None
• Description: Transmembrane protein 14C [Source:UniProtKB/Swiss-Prot;Acc:Q5R751]

Sequence

>retro_pabe_1473
GCACGGGTTGTTTCCGGTGGGGTTGTTGGCTGTGTGAAGCAGGCAGTGTGCCTCTCTGGCTGTGGGGCTCTCTTCGGTGG
TGTAGCAGGCCTGAGTGCTTATTAGCCGTCTCGGGATCCAGGGAACATTTGGGTTTTCCCAGCTACACCTGGAACCTTGG
TGGGCATATGGGAATGAGATCCTACCACTCTGGAAGTTTCATGCCCACAGGTTTAATTGCA

Alignment

ORF - retro_pabe_1473 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 62.5 %
• Parental protein coverage: 67.26 %
• Number of stop codons detected: 1
• Number of frameshifts detected: 4

Retrocopy - Parental Gene Alignment:

Parental  ALVASGGIIGYAK-AGSVP-SLAAGL-LFGSLASLGAYQLSQDPRNVWVFLAATSVTFVGV-MGMRSYYY
          A.V.SGG..G..K.AGSVP.SLA.GL.LFG..A.L.AY..S.DP.N.WVF..AT..T.VG..MGMRSY..
Retrocopy ARVVSGGVVGCVK<AGSVP<SLAVGL<LFGGVAGLSAY*PSRDPGNIWVF-PATPGTLVGI<MGMRSYHS

Parental  GKFMPVGLIA
          G.FMP.GLIA
Retrocopy GSFMPTGLIA

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.11 RPM	32.51 RPM
SRP007412_cerebellum	0.00 RPM	31.74 RPM
SRP007412_heart	0.00 RPM	33.81 RPM
SRP007412_kidney	0.33 RPM	47.73 RPM
SRP007412_liver	0.06 RPM	43.79 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_1473 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_1473 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_1473 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_1793

---

Parental genes homology:

Parental genes homology involve 23 parental genes, and 49 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000002614	3 retrocopies	retro_amel_1256, retro_amel_939, retro_amel_957,
Bos taurus	ENSBTAG00000005808	1 retrocopy	retro_btau_970,
Canis familiaris	ENSCAFG00000009692	2 retrocopies	retro_cfam_115, retro_cfam_1716,
Callithrix jacchus	ENSCJAG00000004957	1 retrocopy	retro_cjac_725,
Dasypus novemcinctus	ENSDNOG00000007732	6 retrocopies	retro_dnov_1220, retro_dnov_1547, retro_dnov_1968, retro_dnov_289, retro_dnov_316, retro_dnov_367,
Equus caballus	ENSECAG00000026994	1 retrocopy	retro_ecab_659,
Erinaceus europaeus	ENSEEUG00000009000	1 retrocopy	retro_eeur_26,
Felis catus	ENSFCAG00000014178	5 retrocopies	retro_fcat_301, retro_fcat_314, retro_fcat_367, retro_fcat_93, retro_fcat_983,
Homo sapiens	ENSG00000137210	1 retrocopy	retro_hsap_684,
Gorilla gorilla	ENSGGOG00000009702	1 retrocopy	retro_ggor_4,
Loxodonta africana	ENSLAFG00000009795	2 retrocopies	retro_lafr_1233, retro_lafr_1246,
Macropus eugenii	ENSMEUG00000000210	1 retrocopy	retro_meug_1704,
Mustela putorius furo	ENSMPUG00000000613	2 retrocopies	retro_mputfur_1322, retro_mputfur_226,
Mus musculus	ENSMUSG00000021361	2 retrocopies	retro_mmus_1634, retro_mmus_2355,
Oryctolagus cuniculus	ENSOCUG00000016368	3 retrocopies	retro_ocun_1129, retro_ocun_1348, retro_ocun_284,
Otolemur garnettii	ENSOGAG00000012165	3 retrocopies	retro_ogar_1155, retro_ogar_2425, retro_ogar_3462,
Ochotona princeps	ENSOPRG00000014366	4 retrocopies	retro_opri_192, retro_opri_29, retro_opri_409, retro_opri_898,
Pongo abelii	ENSPPYG00000016225	1 retrocopy	retro_pabe_1473 ,
Rattus norvegicus	ENSRNOG00000015437	2 retrocopies	retro_rnor_1595, retro_rnor_33,
Sarcophilus harrisii	ENSSHAG00000011456	1 retrocopy	retro_shar_177,
Sus scrofa	ENSSSCG00000001038	3 retrocopies	retro_sscr_438, retro_sscr_449, retro_sscr_614,
Ictidomys tridecemlineatus	ENSSTOG00000022833	1 retrocopy	retro_itri_47,
Tursiops truncatus	ENSTTRG00000003666	2 retrocopies	retro_ttru_1504, retro_ttru_258,