RetrogeneDB ID:

retro_hsap_74

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:X:90690576..90691725(+)
Located in intron of:None
Retrocopy
information
Ensembl ID:ENSG00000174740
Aliases:PABPC5, PABP5
Status:KNOWN_PROTEIN_CODING
Parental gene
information
Parental gene summary:
Parental gene symbol:PABPC4
Ensembl ID:ENSG00000090621
Aliases:PABPC4, APP-1, APP1, PABP4, iPABP
Description:poly(A) binding protein, cytoplasmic 4 (inducible form) [Source:HGNC Symbol;Acc:8557]


Retrocopy-Parental alignment summary:






>retro_hsap_74
ATGGGGAGCGGGGAGCCTAATCCTGCTGGCAAGAAAAAGAAGTATCTCAAGGCCGCTCTGTACGTGGGTGACTTGGACCC
AGATGTCACCGAGGACATGCTCTATAAGAAGTTCAGGCCTGCTGGCCCTCTGCGATTCACCCGAATCTGCCGTGATCCGG
TGACCCGCAGCCCCCTGGGCTATGGGTATGTTAACTTCCGCTTTCCCGCGGATGCAGAGTGGGCCTTGAACACCATGAAT
TTTGATTTGATTAATGGAAAACCATTCCGCCTTATGTGGTCTCAGCCAGATGACCGCTTAAGAAAGTCTGGAGTGGGAAA
TATATTCATCAAAAACCTGGACAAATCCATAGACAATAGGGCCCTGTTTTACTTATTTTCTGCTTTTGGGAACATTCTGT
CCTGCAAAGTCGTATGCGATGACAACGGCTCTAAGGGTTATGCCTATGTTCACTTTGACAGCCTGGCCGCTGCCAATAGA
GCCATCTGGCACATGAATGGAGTGCGGCTCAACAACCGCCAGGTGTATGTTGGCAGATTCAAATTCCCAGAAGAGCGGGC
GGCTGAGGTCAGAACCAGGGATAGAGCAACTTTCACCAATGTTTTCGTTAAAAACATTGGAGACGACATAGATGACGAAA
AACTGAAGGAACTTTTCTGTGAATATGGGCCAACTGAGAGTGTTAAAGTAATAAGAGATGCCAGTGGGAAATCTAAAGGC
TTTGGATTTGTGAGATATGAGACACACGAGGCTGCCCAAAAGGCTGTGCTAGACTTGCATGGAAAGTCCATCGATGGAAA
AGTCCTCTATGTAGGGCGAGCACAGAAGAAAATTGAACGCCTGGCTGAGTTGAGGCGGAGATTTGAACGGCTGAGGTTAA
AAGAAAAAAGTCGGCCCCCAGGGGTGCCTATCTATATTAAGAACTTGGATGAGACAATCAATGATGAAAAACTGAAGGAG
GAATTTTCTTCCTTTGGGTCAATTAGTCGGGCCAAAGTGATGATGGAAGTGGGGCAAGGCAAAGGATTTGGTGTGGTCTG
CTTTTCCTCTTTTGAAGAGGCTACCAAAGCAGTGGATGAGATGAATGGCCGCATAGTGGGCTCCAAGCCCCTGCATGTCA
CCCTGGGCCAGGCCAGGCGCAGGTGCTGA

ORF - retro_hsap_74 Open Reading Frame is conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 66.58 %
Parental protein coverage: 59.19 %
Number of stop codons detected: 0
Number of frameshifts detected 0


Retrocopy - Parental Gene Alignment:

ParentalYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVI
Y..A.LYVGDL..DVTE.MLY.KF.PAGP....R.CRD..TR..LGY.YVNF..PADAE.AL.TMNFD.I
RetrocopyYLKAALYVGDLDPDVTEDMLYKKFRPAGPLRFTRICRDPVTRSPLGYGYVNFRFPADAEWALNTMNFDLI
ParentalKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFET
.GKP.R.MWSQ.D..LRKSGVGN.FIKNLDKSIDN.AL...FSAFGNILSCKVVCD.NGSKGYA.VHF..
RetrocopyNGKPFRLMWSQPDDRLRKSGVGNIFIKNLDKSIDNRALFYLFSAFGNILSCKVVCDDNGSKGYAYVHFDS
ParentalQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAELGAKAK-EFTNVYIKNFGEEVDDESLKELFSQFGK
..AA..AI..MNG..LN.R.V.VGRFK...ER.AE........FTNV..KN.G...DDE.LKELF...G.
RetrocopyLAAANRAIWHMNGVRLNNRQVYVGRFKFPEERAAEVRTRDRATFTNVFVKNIGDDIDDEKLKELFCEYGP
ParentalTLSVKVMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQE
T.SVKV.RD..GKSKGFGFV.YE.HE.A.KAV....GK.I.GK...VGRAQKK.ER.AEL.R.FE.L...
RetrocopyTESVKVIRDASGKSKGFGFVRYETHEAAQKAVLDLHGKSIDGKVLYVGRAQKKIERLAELRRRFERLRLK
ParentalRISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGR
..SR..GV..YIKNLD.TI.DEKL..EFS.FGSI..AKVM.E.G..KGFG.VCFSS.EEATKAV.EMNGR
RetrocopyEKSRPPGVPIYIKNLDETINDEKLKEEFSSFGSISRAKVMMEVGQGKGFGVVCFSSFEEATKAVDEMNGR
ParentalIVGSKPLYVALAQRK
IVGSKPL.V.L.Q..
RetrocopyIVGSKPLHVTLGQAR

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 1 .87 RPM 159 .98 RPM
bodymap2_adrenal 0 .51 RPM 108 .10 RPM
bodymap2_brain 1 .24 RPM 45 .36 RPM
bodymap2_breast 1 .15 RPM 121 .50 RPM
bodymap2_colon 1 .33 RPM 144 .98 RPM
bodymap2_heart 0 .33 RPM 106 .45 RPM
bodymap2_kidney 0 .81 RPM 70 .11 RPM
bodymap2_liver 0 .11 RPM 60 .43 RPM
bodymap2_lung 0 .62 RPM 96 .19 RPM
bodymap2_lymph_node 0 .82 RPM 123 .71 RPM
bodymap2_ovary 2 .62 RPM 152 .23 RPM
bodymap2_prostate 1 .56 RPM 126 .78 RPM
bodymap2_skeletal_muscle 0 .00 RPM 882 .33 RPM
bodymap2_testis 2 .11 RPM 252 .48 RPM
bodymap2_thyroid 1 .32 RPM 153 .78 RPM
bodymap2_white_blood_cells 0 .00 RPM 134 .07 RPM

ChIP-Seq - click to see more details

RNA Polymerase II actvity may be related with retro_hsap_74 in 3 libraries
ENCODE library ID Target ChIP-Seq Peak coordinates
ENCFF002CGN POLR2A X:90689716..90690005
ENCFF002CVJ POLR2A X:90689762..90689968
ENCFF002DBT POLR2A X:90689696..90690066

EST - click to see more details

2 EST(s) were mapped to retro_hsap_74 retrocopy
EST ID Start End Identity Match Mis-match Score
DA368023 90690571 90690902 97.9 330 0 326
EL736616 90690576 90691176 99.9 598 1 597

TSS - click to see more details

No TSS is located nearby retro_hsap_74 retrocopy 5' end.

Lab - click to see more details

retro_hsap_74 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_74 has 0 orthologous retrocopies within eutheria group .

Parental genes homology:
Parental genes homology involve 22 parental genes, and 44 retrocopies.

Species Parental gene accession Retrocopies number
Ailuropoda melanoleuca ENSAMEG000000115352 retrocopies
retro_amel_107, retro_amel_676,
Callithrix jacchus ENSCJAG000000025123 retrocopies
retro_cjac_214, retro_cjac_2722, retro_cjac_284,
Cavia porcellus ENSCPOG000000095522 retrocopies
retro_cpor_1330, retro_cpor_77,
Felis catus ENSFCAG000000152542 retrocopies
retro_fcat_116, retro_fcat_545,
Homo sapiens ENSG000000707561 retrocopy
retro_hsap_88,
Homo sapiens ENSG000000760671 retrocopy
retro_hsap_1143,
Homo sapiens ENSG00000090621 2 retrocopies
retro_hsap_109, retro_hsap_74 ,
Homo sapiens ENSG000001532501 retrocopy
retro_hsap_1131,
Gorilla gorilla ENSGGOG000000040023 retrocopies
retro_ggor_2127, retro_ggor_87, retro_ggor_916,
Microcebus murinus ENSMICG000000166331 retrocopy
retro_mmur_675,
Macaca mulatta ENSMMUG000000074971 retrocopy
retro_mmul_178,
Monodelphis domestica ENSMODG000000176572 retrocopies
retro_mdom_1090, retro_mdom_1805,
Mustela putorius furoENSMPUG000000144142 retrocopies
retro_mputfur_152, retro_mputfur_546,
Mus musculus ENSMUSG000000112577 retrocopies
retro_mmus_2006, retro_mmus_2326, retro_mmus_2327, retro_mmus_798, retro_mmus_801, retro_mmus_803, retro_mmus_805,
Nomascus leucogenys ENSNLEG000000119282 retrocopies
retro_nleu_1517, retro_nleu_62,
Oryctolagus cuniculus ENSOCUG000000005622 retrocopies
retro_ocun_153, retro_ocun_792,
Otolemur garnettii ENSOGAG000000040671 retrocopy
retro_ogar_71,
Ochotona princeps ENSOPRG000000119841 retrocopy
retro_opri_1133,
Pongo abelii ENSPPYG000000015062 retrocopies
retro_pabe_190, retro_pabe_2563,
Pan troglodytes ENSPTRG000000005733 retrocopies
retro_ptro_101, retro_ptro_2093, retro_ptro_8,
Rattus norvegicus ENSRNOG000000156422 retrocopies
retro_rnor_175, retro_rnor_92,
Sarcophilus harrisii ENSSHAG000000181391 retrocopy
retro_shar_823,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) Legend:


Library Retrogene expression
CEU_NA11831 0 .00 RPM
CEU_NA11843 0 .00 RPM
CEU_NA11930 0 .00 RPM
CEU_NA12004 0 .00 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .00 RPM
CEU_NA12760 0 .00 RPM
CEU_NA12827 0 .00 RPM
CEU_NA12872 0 .00 RPM
CEU_NA12873 0 .00 RPM
FIN_HG00183 0 .00 RPM
FIN_HG00277 0 .00 RPM
FIN_HG00315 0 .00 RPM
FIN_HG00321 0 .00 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .00 RPM
FIN_HG00349 0 .00 RPM
FIN_HG00375 0 .00 RPM
FIN_HG00377 0 .00 RPM
FIN_HG00378 0 .00 RPM
GBR_HG00099 0 .00 RPM
GBR_HG00111 0 .00 RPM
GBR_HG00114 0 .00 RPM
GBR_HG00119 0 .00 RPM
GBR_HG00131 0 .00 RPM
GBR_HG00133 0 .00 RPM
GBR_HG00134 0 .00 RPM
GBR_HG00137 0 .00 RPM
GBR_HG00142 0 .00 RPM
GBR_HG00143 0 .00 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .00 RPM
TSI_NA20518 0 .00 RPM
TSI_NA20532 0 .00 RPM
TSI_NA20538 0 .00 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .00 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .00 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .00 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .00 RPM
YRI_NA19093 0 .00 RPM
YRI_NA19099 0 .00 RPM
YRI_NA19114 0 .00 RPM
YRI_NA19118 0 .00 RPM
YRI_NA19213 0 .00 RPM
YRI_NA19214 0 .00 RPM
YRI_NA19223 0 .00 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).





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