RetrogeneDB ID:

retro_hsap_1876

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:18:26231694..26233174(+)
Located in intron of:None
Retrocopy
information
Ensembl ID:ENSG00000266296
Aliases:None
Status:KNOWN_PSEUDOGENE
Parental gene
information
Parental gene summary:
Parental gene symbol:ARIH2
Ensembl ID:ENSG00000177479
Aliases:ARIH2, ARI2, TRIAD1
Description:ariadne homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:690]


Retrocopy-Parental alignment summary:






>retro_hsap_1876
ATGTCCGTGGACATGAATAGCCAGGGGTCTGACAGCAATGAAAAGCACTATGACTCAAATTGTGAGGAAGAGGAACAAGA
AGAGGATGAAGACCCTGGGGACATAGAGGACTATTACCTGGGAGTAGCCAGCAATGTGGAGCAGCAGGGGGCTGATGCCT
TTGATCCTGAGGAGTACTAGTTCACTTACTTGACCTACAAGAAATCTGAGGGTGCCCTGAACGAGCACATGACCAGCTTA
GCCTCTGTCCTAAAGGTATCTCATTCAGTTGCTAAACTTATATTAGTTAATTTCCATTGGCAAGTTTCAGAGAGATTGGA
CAGATACAAGTCCAATTCTGCTCAACTGCTCGTTGAGGCTCGAGTTCAGCCTAATCCATCAAAACATGTTCCCGCATCTC
ATCCCCCTCACCTCTGTGCAGTGTGTATGCAGTTTGCGCGAAAGAAAAACCTACTCTCCCTGGTCTGTCAGCACCAGTTT
TGCCGTAGCTGCTTGGAGCAGCACTGCTCAGTTCTCGTTAAGGATGGTGTGGGTGTGGGAGTCGCTTGCATGGCTCAGGA
CTGTCCCACTCCATACACCAGAGGACTTTGTGTTTCCATTGCTTCCCAATGAAGAATTGAGAGAGAAATACAGGTGCTAC
CTCTTCAGGGACTATGTGAAGAGTCATTACTAGCTCCAGCTGTGCCCTGGTGCAGACTGCCTCATGGTTGTTCGGGTACA
GGAGCCTAGAGCTCACCGAGTATAGTGCAATCGGTGCAACGAGGTCTTCTGTTTCAAGTGTCATCAAATATATCACGCAC
CCACAGACCGCATCACCATCCGAAAATGGCTCAAGAAGTGTGCAGACAACTCTGAAACAGCCGACTACAGTAGTGCTCAC
ACTAAAGACTGTCCCGAATACAACATCTGCATTGAGAAGAATGGAGGCTGCAATCACATGCAATGCTCCAAATGTAAACA
CGACTTCTGCTGGACATATCTAGGAGATTGGAAGGCACATGGCAGTGAATAATATGAGTGCAGTACTTACAAGGAGAATC
CTGACATTGTGAACCAGCGCCAACAAGCCCAGGCGAGGGAAGCCCTCAAAAAGTACTTATTCTACTTTGAGAGGTGGGAA
AACCACAACAAAAGCTTGCAGCTAGAGGCACAGACATACCAGCAGATTCATGAGAAGATTCAGGAGAGGGTCATGAACAA
TCTGGGGACATGGATTGACTGGCAGTACCTACAGAGTGCAGCCAAGCTCTTGGCCAGGTGTTGATACACCCTGCAGTACA
TCAACCCATATACATATTACATGGAGTCTGGACCCAGGAATGAGCTGTTTGAATACCAGCAGGCTGAGCAGGAGGCTGAA
ATTGAAAACCTCTCATGGAAAGTGGAACATGCAGACAGCTATGACAGAGGGGACTTGGAGAACCAGATGCATGTAGCCGA
GCAGTGGAGGAGAACCCTGCTGAAGGATTTCCATGACACC

ORF - retro_hsap_1876 Open Reading Frame is not conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 88.26 %
Parental protein coverage: 100. %
Number of stop codons detected: 5
Number of frameshifts detected 1


Retrocopy - Parental Gene Alignment:

ParentalMSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESE
MSVDMNSQGSDSNE..YD.NCEEEE.EE..DPGDIEDYY.GVAS.VEQQGADAFDPEEY.FT.LTYK.SE
RetrocopyMSVDMNSQGSDSNEKHYDSNCEEEEQEEDEDPGDIEDYYLGVASNVEQQGADAFDPEEY*FTYLTYKKSE
ParentalGALNEHMTSLASVLKVSHSVAKLILVNFHWQVSEILDRYKSNSAQLLVEARVQPNPSKHVPTSHPPHHCA
GALNEHMTSLASVLKVSHSVAKLILVNFHWQVSE.LDRYKSNSAQLLVEARVQPNPSKHVP.SHPPH.CA
RetrocopyGALNEHMTSLASVLKVSHSVAKLILVNFHWQVSERLDRYKSNSAQLLVEARVQPNPSKHVPASHPPHLCA
ParentalVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDCP-LRTPEDFVFPLLPNEELREK
VCMQF.RK.NLLSL.CQHQFCRSC.EQHCSVLVKDGVGVGV.CMAQDCP.L.TPEDFVFPLLPNEELREK
RetrocopyVCMQFARKKNLLSLVCQHQFCRSCLEQHCSVLVKDGVGVGVACMAQDCP>LHTPEDFVFPLLPNEELREK
ParentalYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTK
YR.YLFRDYV.SHY.LQLCPGADC.MV.RVQEPRA.RV.CNRCNEVFCFKC.Q.YHAPTD..TIRKWL.K
RetrocopyYRCYLFRDYVKSHY*LQLCPGADCLMVVRVQEPRAHRV*CNRCNEVFCFKCHQIYHAPTDRITIRKWLKK
ParentalCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDI
CAD.SETA.Y.SAHTKDCP..NICIEKNGGCNHMQCSKCKHDFCW..LGDWK.HGSE.YECS.YKENPDI
RetrocopyCADNSETADYSSAHTKDCPEYNICIEKNGGCNHMQCSKCKHDFCWTYLGDWKAHGSE*YECSTYKENPDI
ParentalVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAK
VNQ.QQAQAREALKKYLFYFERWENHNKSLQLEAQTYQ.IHEKIQERVMNNLGTWIDWQYLQ.AAKLLA.
RetrocopyVNQRQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQQIHEKIQERVMNNLGTWIDWQYLQSAAKLLAR
ParentalCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKD
C.YTLQY..PY.YYMESGPR..LFEYQQA..EAEIENLSWKVE.ADSYDRGDLENQMH.AEQ.RRTLLKD
RetrocopyC*YTLQYINPYTYYMESGPRNELFEYQQAEQEAEIENLSWKVEHADSYDRGDLENQMHVAEQWRRTLLKD
ParentalFHDT
FHDT
RetrocopyFHDT

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 0 .00 RPM 52 .28 RPM
bodymap2_adrenal 0 .00 RPM 76 .17 RPM
bodymap2_brain 0 .00 RPM 56 .98 RPM
bodymap2_breast 0 .00 RPM 57 .20 RPM
bodymap2_colon 0 .02 RPM 44 .84 RPM
bodymap2_heart 0 .04 RPM 137 .66 RPM
bodymap2_kidney 0 .00 RPM 57 .26 RPM
bodymap2_liver 0 .02 RPM 33 .82 RPM
bodymap2_lung 0 .00 RPM 54 .36 RPM
bodymap2_lymph_node 0 .00 RPM 82 .29 RPM
bodymap2_ovary 0 .02 RPM 73 .81 RPM
bodymap2_prostate 0 .00 RPM 57 .66 RPM
bodymap2_skeletal_muscle 0 .00 RPM 80 .85 RPM
bodymap2_testis 0 .00 RPM 61 .65 RPM
bodymap2_thyroid 0 .04 RPM 79 .69 RPM
bodymap2_white_blood_cells 0 .00 RPM 56 .64 RPM

ChIP-Seq - click to see more details

RNA Polymerase II actvity near the 5' end of retro_hsap_1876 was not detected

EST - click to see more details

No EST(s) were mapped for retro_hsap_1876 retrocopy.

TSS - click to see more details

No TSS is located nearby retro_hsap_1876 retrocopy 5' end.

Lab - click to see more details

retro_hsap_1876 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_1876 has 4 orthologous retrocopies within eutheria group .

Species RetrogeneDB ID
Pan troglodytes retro_ptro_1259
Gorilla gorilla retro_ggor_1373
Pongo abelii retro_pabe_1557
Callithrix jacchus retro_cjac_1106
Parental genes homology:
Parental genes homology involve 12 parental genes, and 12 retrocopies.

Species Parental gene accession Retrocopies number
Ailuropoda melanoleuca ENSAMEG000000130351 retrocopy
retro_amel_1021,
Callithrix jacchus ENSCJAG000000033051 retrocopy
retro_cjac_1106,
Homo sapiens ENSG00000177479 1 retrocopy
retro_hsap_1876 ,
Gorilla gorilla ENSGGOG000000171341 retrocopy
retro_ggor_1373,
Myotis lucifugus ENSMLUG000000139461 retrocopy
retro_mluc_1869,
Mustela putorius furoENSMPUG000000143441 retrocopy
retro_mputfur_610,
Mus musculus ENSMUSG000000641451 retrocopy
retro_mmus_795,
Nomascus leucogenys ENSNLEG000000067101 retrocopy
retro_nleu_1228,
Oryctolagus cuniculus ENSOCUG000000176991 retrocopy
retro_ocun_1838,
Pongo abelii ENSPPYG000000138901 retrocopy
retro_pabe_1557,
Pan troglodytes ENSPTRG000000149021 retrocopy
retro_ptro_1259,
Ictidomys tridecemlineatus ENSSTOG000000017661 retrocopy
retro_itri_1047,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) > 0 RPM = 0.04 RPM Legend:


Library Retrogene expression
CEU_NA11831 0 .00 RPM
CEU_NA11843 0 .00 RPM
CEU_NA11930 0 .00 RPM
CEU_NA12004 0 .00 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .02 RPM
CEU_NA12760 0 .00 RPM
CEU_NA12827 0 .00 RPM
CEU_NA12872 0 .00 RPM
CEU_NA12873 0 .00 RPM
FIN_HG00183 0 .00 RPM
FIN_HG00277 0 .00 RPM
FIN_HG00315 0 .00 RPM
FIN_HG00321 0 .03 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .02 RPM
FIN_HG00349 0 .00 RPM
FIN_HG00375 0 .02 RPM
FIN_HG00377 0 .00 RPM
FIN_HG00378 0 .00 RPM
GBR_HG00099 0 .03 RPM
GBR_HG00111 0 .00 RPM
GBR_HG00114 0 .00 RPM
GBR_HG00119 0 .00 RPM
GBR_HG00131 0 .00 RPM
GBR_HG00133 0 .00 RPM
GBR_HG00134 0 .04 RPM
GBR_HG00137 0 .00 RPM
GBR_HG00142 0 .00 RPM
GBR_HG00143 0 .03 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .00 RPM
TSI_NA20518 0 .00 RPM
TSI_NA20532 0 .00 RPM
TSI_NA20538 0 .00 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .02 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .00 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .00 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .00 RPM
YRI_NA19093 0 .00 RPM
YRI_NA19099 0 .00 RPM
YRI_NA19114 0 .00 RPM
YRI_NA19118 0 .00 RPM
YRI_NA19213 0 .00 RPM
YRI_NA19214 0 .02 RPM
YRI_NA19223 0 .00 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).





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