RetrogeneDB ID: retro_pabe_623

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 10:98792255..98792793(-)
• Located in intron of: ENSPPYG00000002558

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: None
• Ensembl ID: ENSPPYG00000004233
• Aliases: None
• Description: None

Sequence

>retro_pabe_623
ACTCAGAGGCTCTCTCATCTTCCTTCCTCTGTGGATCTATTTATTCAGGAAAGTCCTAATTCTTCCACTAGTCCCAAAGT
AAAACTACGCACTTCTGCAGAGAAGAGCACAGTGAAGAATGAAGATAAGATCCAGGTGAAGAAACAGAAGACCAGAAACA
TGTTCTCTCTGGCCCAGCTGTGTGTAATTAATGATGGATTTCAGAGACAGAAACGCCGCAGCCTCCAGCAGCTGCAAGAA
CTTTCCAATACCCTGAATCTTAGCTACAAACAGCATACAAGCTGGTTACAGAGAATGAAAGCTAAGAGGTGGTAGAAAGC
CAACTGACCAAAGAATAAGCAACAGTATAACTCAGGACTCAGCATCTACAGAATACCCAGGCCTCTCCTCTTCCTACCAC
CAGGGATGCCTGGGGAACACATCTGGAAGCCTTCCAGTGTGGATCAACCATTCCCAGAAAAGTCAGACTTGGCACCCAGA
AGACTAGAACAACCAGTCCCGGAAAAATCGGTTTCATAACTGTGGGGAGGAATCTTGG

Alignment

ORF - retro_pabe_623 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 57.14 %
• Parental protein coverage: 58.69 %
• Number of stop codons detected: 3
• Number of frameshifts detected: 1

Retrocopy - Parental Gene Alignment:

Parental  TETVSPLPSSMDLLIQDSPDSSTSPKGKQPTAAENSATKKEDKVPVKKQKTRTVFSSTQLCVLNDRFQRQ
          T...S.LPSS.DL.IQ.SP.SSTSPK.K..T.AE.S..K.EDK..VKKQKTR..FS..QLCV.ND.FQRQ
Retrocopy TQRLSHLPSSVDLFIQESPNSSTSPKVKLRTSAEKSTVKNEDKIQVKKQKTRNMFSLAQLCVINDGFQRQ

Parental  KYLSLQQMQELSNILNLSYKQVKTWFQNQRMKSKRWQKNNWPKN-SNGVTQKASAPTYPSLYSSYHQGCL
          K..SLQQ.QELSN.LNLSYKQ...W...QRMK.KRW.K.N.PKN.SN..TQ......YP.L.SSYHQGCL
Retrocopy KRRSLQQLQELSNTLNLSYKQHTSWL--QRMKAKRW*KAN*PKN>SNSITQDSASTEYPGLSSSYHQGCL

Parental  VNPTGNLPMWSNQTWSNSSWSNQTQNIQSWSN--HSWNTQTW
          .N..G.LP.W.N.......W.....N.QS..N..H......W
Retrocopy GNTSGSLPVWINHSQKSQTWHPED*NNQSRKNRFHNCGEESW

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	0.00 RPM
SRP007412_cerebellum	0.00 RPM	0.00 RPM
SRP007412_heart	0.00 RPM	0.00 RPM
SRP007412_kidney	0.00 RPM	0.00 RPM
SRP007412_liver	0.03 RPM	0.00 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_623 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_623 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_623 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_722
Gorilla gorilla	retro_ggor_608
Macaca mulatta	retro_mmul_2466

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Parental genes homology:

Parental genes homology involve 22 parental genes, and 59 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000017064	1 retrocopy	retro_amel_354,
Canis familiaris	ENSCAFG00000013914	1 retrocopy	retro_cfam_724,
Choloepus hoffmanni	ENSCHOG00000000972	4 retrocopies	retro_chof_1267, retro_chof_264, retro_chof_794, retro_chof_987,
Cavia porcellus	ENSCPOG00000002621	1 retrocopy	retro_cpor_1132,
Echinops telfairi	ENSETEG00000004648	8 retrocopies	retro_etel_1155, retro_etel_1334, retro_etel_134, retro_etel_1434, retro_etel_1935, retro_etel_630, retro_etel_818, retro_etel_963,
Felis catus	ENSFCAG00000001621	1 retrocopy	retro_fcat_932,
Homo sapiens	ENSG00000111704	5 retrocopies	retro_hsap_1455, retro_hsap_1549, retro_hsap_3713, retro_hsap_4814, retro_hsap_722,
Gorilla gorilla	ENSGGOG00000028196	4 retrocopies	retro_ggor_1812, retro_ggor_2510, retro_ggor_3000, retro_ggor_608,
Macropus eugenii	ENSMEUG00000009949	2 retrocopies	retro_meug_266, retro_meug_940,
Microcebus murinus	ENSMICG00000002228	1 retrocopy	retro_mmur_575,
Myotis lucifugus	ENSMLUG00000029325	2 retrocopies	retro_mluc_1562, retro_mluc_2054,
Myotis lucifugus	ENSMLUG00000030580	1 retrocopy	retro_mluc_169,
Macaca mulatta	ENSMMUG00000032158	4 retrocopies	retro_mmul_1901, retro_mmul_2466, retro_mmul_964, retro_mmul_979,
Monodelphis domestica	ENSMODG00000017979	2 retrocopies	retro_mdom_1293, retro_mdom_1938,
Mustela putorius furo	ENSMPUG00000016731	5 retrocopies	retro_mputfur_1140, retro_mputfur_1553, retro_mputfur_261, retro_mputfur_553, retro_mputfur_691,
Nomascus leucogenys	ENSNLEG00000005359	3 retrocopies	retro_nleu_1086, retro_nleu_2189, retro_nleu_2340,
Oryctolagus cuniculus	ENSOCUG00000013783	1 retrocopy	retro_ocun_971,
Otolemur garnettii	ENSOGAG00000026339	1 retrocopy	retro_ogar_568,
Procavia capensis	ENSPCAG00000015460	2 retrocopies	retro_pcap_143, retro_pcap_429,
Pongo abelii	ENSPPYG00000004233	5 retrocopies	retro_pabe_2157, retro_pabe_3142, retro_pabe_3440, retro_pabe_3742, retro_pabe_623 ,
Pan troglodytes	ENSPTRG00000029807	4 retrocopies	retro_ptro_1746, retro_ptro_2514, retro_ptro_3203, retro_ptro_990,
Pteropus vampyrus	ENSPVAG00000006989	1 retrocopy	retro_pvam_1251,