RetrogeneDB ID: retro_pabe_2291

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 3:12884939..12885527(-)
• Located in intron of: ENSPPYG00000013508

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: PHB
• Ensembl ID: ENSPPYG00000008920
• Aliases: None
• Description: prohibitin [Source:HGNC Symbol;Acc:8912]

Sequence

>retro_pabe_2291
AGCTGCCAAGTGTTTGAGTCCATCGGCATGTTTGGGCTGGCCTTAGCTGTTGCAGGAGGCCTGGTGAACTCTGCTTTATA
TAACATGGATGCTGGGCACAGAGCTGTCATCTTTGACCGATTCTGTGGAGTACAGGATATTGTGGTAGGGTAAGGGACTC
ACTTTCTCATACCATGGGTACAGAAACCAATTATCTTTGACCACTGTTCTCAACCACGTAATGTGCCAGTCATCACTGGT
AGCAAAGATTTACAGAATGTCAACATCATACTGTGCATCCTCTTTGGGCCTGTCACTAGCCAGCTTCCTCGCATCTTCAC
CAGCATCAGAGAAGACTGTGATGAGTGTGTGCTGCCATCCATCACTACCGAGATCCTCAAGTCAGTGGTGGCTCGCTTTG
ATGCTGGAGAACTAATCACCCAGAGAGAGCTGGTCTCCAGGCAGGTGAGCGACGACCTTACGGAGCGAGCAGCCACCTTC
GGGCTCATCCTGGACGATGTGTCTTTGACACATCTGACCTTCGGGAAGGAGTTCACAGAAGCAGTAGAAGCCAAACAGGT
GGCTCAGCAGGATGCAGAGAGGGCCAGA

Alignment

ORF - retro_pabe_2291 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 90.31 %
• Parental protein coverage: 72.06 %
• Number of stop codons detected: 1
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  AAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRS
          ...VFESIG.FGLALAVAGG.VNSALYN.DAGHRAVIFDRF.GVQDIVVG.GTHFLIPWVQKPIIFD..S
Retrocopy SCQVFESIGMFGLALAVAGGLVNSALYNMDAGHRAVIFDRFCGVQDIVVG*GTHFLIPWVQKPIIFDHCS

Parental  RPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELIT
          .PRNVPVITGSKDLQNVNI.L.ILF.PV.SQLPRIFTSI.ED.DE.VLPSITTEILKSVVARFDAGELIT
Retrocopy QPRNVPVITGSKDLQNVNIILCILFGPVTSQLPRIFTSIREDCDECVLPSITTEILKSVVARFDAGELIT

Parental  QRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERAR
          QRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQ.AERAR
Retrocopy QRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQDAERAR

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	84.54 RPM
SRP007412_cerebellum	0.12 RPM	38.79 RPM
SRP007412_heart	0.09 RPM	81.52 RPM
SRP007412_kidney	0.00 RPM	193.51 RPM
SRP007412_liver	0.24 RPM	78.40 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_2291 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_2291 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_2291 has 4 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_2692
Pan troglodytes	retro_ptro_1817
Gorilla gorilla	retro_ggor_1876
Macaca mulatta	retro_mmul_1425

---

Parental genes homology:

Parental genes homology involve 16 parental genes, and 123 retrocopies.

Species	Parental gene accession	Retrocopies number
Anolis carolinensis	ENSACAG00000004797	1 retrocopy	retro_acar_49,
Canis familiaris	ENSCAFG00000016926	1 retrocopy	retro_cfam_202,
Choloepus hoffmanni	ENSCHOG00000007588	2 retrocopies	retro_chof_1159, retro_chof_2193,
Callithrix jacchus	ENSCJAG00000007174	22 retrocopies	retro_cjac_1048, retro_cjac_1403, retro_cjac_1683, retro_cjac_1761, retro_cjac_1820, retro_cjac_2261, retro_cjac_2389, retro_cjac_2390, retro_cjac_2391, retro_cjac_2445, retro_cjac_2523, retro_cjac_2659, retro_cjac_2663, retro_cjac_2909, retro_cjac_4205, retro_cjac_570, retro_cjac_635, retro_cjac_662, retro_cjac_872, retro_cjac_937, retro_cjac_966, retro_cjac_980,
Erinaceus europaeus	ENSEEUG00000006481	3 retrocopies	retro_eeur_219, retro_eeur_285, retro_eeur_369,
Homo sapiens	ENSG00000167085	15 retrocopies	retro_hsap_1113, retro_hsap_1514, retro_hsap_161, retro_hsap_1640, retro_hsap_2170, retro_hsap_2692, retro_hsap_3534, retro_hsap_3750, retro_hsap_3868, retro_hsap_3869, retro_hsap_4186, retro_hsap_4888, retro_hsap_517, retro_hsap_617, retro_hsap_776,
Gorilla gorilla	ENSGGOG00000028002	12 retrocopies	retro_ggor_124, retro_ggor_1722, retro_ggor_1876, retro_ggor_238, retro_ggor_2387, retro_ggor_246, retro_ggor_2607, retro_ggor_3053, retro_ggor_476, retro_ggor_643, retro_ggor_741, retro_ggor_870,
Macropus eugenii	ENSMEUG00000005122	1 retrocopy	retro_meug_708,
Myotis lucifugus	ENSMLUG00000008203	2 retrocopies	retro_mluc_116, retro_mluc_2190,
Macaca mulatta	ENSMMUG00000000156	13 retrocopies	retro_mmul_1096, retro_mmul_1119, retro_mmul_1165, retro_mmul_1425, retro_mmul_151, retro_mmul_1565, retro_mmul_2148, retro_mmul_2420, retro_mmul_426, retro_mmul_521, retro_mmul_834, retro_mmul_866, retro_mmul_933,
Monodelphis domestica	ENSMODG00000012210	1 retrocopy	retro_mdom_812,
Otolemur garnettii	ENSOGAG00000027015	1 retrocopy	retro_ogar_968,
Procavia capensis	ENSPCAG00000008851	1 retrocopy	retro_pcap_74,
Pongo abelii	ENSPPYG00000008920	16 retrocopies	retro_pabe_1262, retro_pabe_1357, retro_pabe_1409, retro_pabe_1770, retro_pabe_2291 , retro_pabe_289, retro_pabe_3030, retro_pabe_3034, retro_pabe_3426, retro_pabe_3427, retro_pabe_3800, retro_pabe_552, retro_pabe_753, retro_pabe_922, retro_pabe_925, retro_pabe_977,
Pan troglodytes	ENSPTRG00000009376	14 retrocopies	retro_ptro_1025, retro_ptro_1110, retro_ptro_154, retro_ptro_1656, retro_ptro_1817, retro_ptro_2401, retro_ptro_2545, retro_ptro_2841, retro_ptro_2964, retro_ptro_3256, retro_ptro_386, retro_ptro_451, retro_ptro_542, retro_ptro_686,
Rattus norvegicus	ENSRNOG00000046799	18 retrocopies	retro_rnor_1058, retro_rnor_1416, retro_rnor_1540, retro_rnor_1542, retro_rnor_2398, retro_rnor_2399, retro_rnor_2610, retro_rnor_2653, retro_rnor_2815, retro_rnor_2826, retro_rnor_2848, retro_rnor_2855, retro_rnor_2909, retro_rnor_292, retro_rnor_2948, retro_rnor_2949, retro_rnor_543, retro_rnor_898,