RetrogeneDB ID: retro_ptro_1303

Retrocopy location

• Organism: Chimpanzee (Pan troglodytes)
• Coordinates: 18:59525723..59526338(-)
• Located in intron of: ENSPTRG00000010083

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: PSMC5
• Ensembl ID: ENSPTRG00000009525
• Aliases: None
• Description: Pan troglodytes proteasome (prosome, macropain) 26S subunit, ATPase, 5 (PSMC5), mRNA. [Source:RefSeq mRNA;Acc:NM_001246524]

Sequence

>retro_ptro_1303
GATGGACCAGAGCAGATGGAGCTGGAAGAGGGGAAGACAGGCAACAGACTCAGCCAGTATTATCTGTCTGAGACTGAAGA
ACTCCAGTCAGTAGTGAATGATAAGAGCCAGGACCTCCAGAGGCTGCAGGCATAAATGAATGAACTCAATGCAAAAGTTC
ACCTATTGCAGGAGGAGCTACAGCTGCTGCAGGAACAGGGCTCCTGTATAAGGGAAATAGTCCGGGCCATGGATAAGGAG
AAAGTGTTAGTCAAGGTGTATCACAAGGGCAAGTTTGTCTTAGATGTGGACAGAAACAGCGACATCAATGACATGAGACC
CAATTGCCAGGGGGTGCTAAGAAATGATAGCGACACACTGCACAATATCATACCCAGCAAAGTAGACCCACTGGTGTCAC
CAGTGATGGTGGAGAAGGTGCCAACCTTGATTTAAGAGATGATTGGTGGACTGGACAAGCAGATTAAGGACATCACAGAA
GTGATCGAGCCGCCTGTTAAGCATCCCAAGCTCTTTGAAGCACTGGGTATCACACAACCCAGGGTGGTACTGCTGTACGG
ACCTCTAGGCACTGGGAAGACACTGTTTGCCTAGGCCGTGGCTCACCATACAGAC

Alignment

ORF - retro_ptro_1303 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 75.61 %
• Parental protein coverage: 50.49 %
• Number of stop codons detected: 3
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  DGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYV
          DGPEQMELEEGK.G..L.QYYLS..EELQ..VNDKSQ.L.RLQA..NELNAKV.LL.EELQLLQEQGS..
Retrocopy DGPEQMELEEGKTGNRLSQYYLSETEELQSVVNDKSQDLQRLQA*MNELNAKVHLLQEELQLLQEQGSCI

Parental  GEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKV
          .E.VRAMDK.KVLVKV...GKFV.DVD.N.DIND..PNC...LRNDS.TLH.I.P.KVDPLVS..MVEKV
Retrocopy REIVRAMDKEKVLVKVYHKGKFVLDVDRNSDINDMRPNCQGVLRNDSDTLHNIIPSKVDPLVSPVMVEKV

Parental  PDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTD
          P....EMIGGLDKQIK.I.EVIE.PVKHP.LFEALGI.QP..VLLYGP.GTGKTL.A.AVAHHTD
Retrocopy PTLI*EMIGGLDKQIKDITEVIEPPVKHPKLFEALGITQPRVVLLYGPLGTGKTLFA*AVAHHTD

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.14 RPM	149.47 RPM
SRP007412_cerebellum	0.32 RPM	184.05 RPM
SRP007412_heart	0.17 RPM	96.71 RPM
SRP007412_kidney	0.24 RPM	161.07 RPM
SRP007412_liver	0.07 RPM	133.16 RPM
SRP007412_testis	0.11 RPM	154.70 RPM

ChIP-Seq

Pan troglodytes was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_ptro_1303 retrocopy.

TSS

Pan troglodytes was not studied using FANTOM5 data.

Lab

retro_ptro_1303 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ptro_1303 has 1 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Pongo abelii	retro_pabe_1606

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Parental genes homology:

Parental genes homology involve 14 parental genes, and 17 retrocopies.

Species	Parental gene accession	Retrocopies number
Dasypus novemcinctus	ENSDNOG00000002393	1 retrocopy	retro_dnov_1508,
Homo sapiens	ENSG00000087191	1 retrocopy	retro_hsap_1949,
Gorilla gorilla	ENSGGOG00000006803	1 retrocopy	retro_ggor_1418,
Macaca mulatta	ENSMMUG00000016769	1 retrocopy	retro_mmul_1354,
Monodelphis domestica	ENSMODG00000009873	2 retrocopies	retro_mdom_1411, retro_mdom_1583,
Nomascus leucogenys	ENSNLEG00000004150	1 retrocopy	retro_nleu_1480,
Oryctolagus cuniculus	ENSOCUG00000004329	1 retrocopy	retro_ocun_78,
Otolemur garnettii	ENSOGAG00000008296	1 retrocopy	retro_ogar_911,
Procavia capensis	ENSPCAG00000002653	1 retrocopy	retro_pcap_352,
Pongo abelii	ENSPPYG00000008533	1 retrocopy	retro_pabe_1606,
Pan troglodytes	ENSPTRG00000009525	1 retrocopy	retro_ptro_1303 ,
Ictidomys tridecemlineatus	ENSSTOG00000008945	1 retrocopy	retro_itri_1046,
Tupaia belangeri	ENSTBEG00000010546	3 retrocopies	retro_tbel_1411, retro_tbel_2422, retro_tbel_3450,
Tursiops truncatus	ENSTTRG00000006984	1 retrocopy	retro_ttru_1532,