RetrogeneDB ID: retro_mmul_1420

Retrocopy location

• Organism: Rhesus macaque (Macaca mulatta)
• Coordinates: 2:20432450..20433143(+)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: VTI1B
• Ensembl ID: ENSMMUG00000015866
• Aliases: None
• Description: vesicle transport through interaction with t-SNAREs homolog 1B [Source:RefSeq peptide;Acc:NP_001253288]

Sequence

>retro_mmul_1420
ATGGCCACCTCCGCCGCCTCCTCGGAGCATTTCAAGAAGCTGTAGGAGATCTTCTACGGCCTCCACGAAGACCTATAAGG
GGTGCCTGAGCGGCTGCTGGGAACGGCGGGGACCGGAGAGAAGAAGAAGTTAATCAGGGATTTTGATGAAAAGCAACGGG
AAGCAAATGAAACGCTGGAGAGATAGAGGAGGAGCTACGTTATGCACCTGTCTTTCTGTAATCCCATGATGTCTAAGTTT
CAAAACTACCAGAAGGACCTCGCCAAACTCCATGGGGTGGTGAGCAGCACACCTTTGACAGCCACACCTGGAGGCCGAAG
AGACATGAAATATGGCATATATGCTGTAGAGAATGAGCATATGAATCGGCTACAGTCTCAAAGGGCAACGCTTCCTCAAG
GCACTGAAAGTCTGAACTAGGCCACCCACAGTATTGAATGTTCTCATCGGATTGCCACGGAGACTGACCAGCTTGGCTCA
GAAATCACAGAAGAGCTGGGCGAACAATGAGACCAGTTAGAATGCACCAAGAGTAGACTGGTAAACACAAGTGAAAACTT
GAGCAACAGTCGAAAGATTCTCCGTTCAATGTCCAGAAAAGTGACAACCAACAAGCTGTTGCTTTCCATCATCATCTTAC
TTTTGCTCGCCATCCTGGGAGGTCTGGTTTACTACAAATTATTTCATAACCAT

Alignment

ORF - retro_mmul_1420 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 79.31 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 5
• Number of frameshifts detected: 0

Retrocopy - Parental Gene Alignment:

Parental  MAASAASSEHFEKLHEIFRGLHEDLQGVPERLLGTAGTEEKKKLIRDFDEKQQEANETLAEMEEELRYAP
          MA.SAASSEHF.KL.EIF.GLHEDL.GVPERLLGTAGT.EKKKLIRDFD...Q.......E.........
Retrocopy MATSAASSEHFKKL*EIFYGLHEDL*GVPERLLGTAGTGEKKKLIRDFD-EKQREANETLER*RRSYVMH

Parental  LSFRNPMMSKLRNYRKDLAKLHREVRSTPLTATPGGRGDMKYGIYALENEHMNRLQSQRAMLLQGTESLN
          LSF.NPMMSK..NY.KDLAKLH..V.STPLTATPGGR.DMKYGIYA.ENEHMNRLQSQRA.L.QGTESLN
Retrocopy LSFCNPMMSKFQNYQKDLAKLHGVVSSTPLTATPGGRRDMKYGIYAVENEHMNRLQSQRATLPQGTESLN

Parental  RATQSIERSHRIATETDQIGSEIIEELGEQRDQLERTKSRLVNTSENLSKSRKILRSMSRKVTTNKLLLS
          .AT.SIE.SHRIATETDQ.GSEI.EELGEQ.DQLE.TKSRLVNTSENLS.SRKILRSMSRKVTTNKLLLS
Retrocopy *ATHSIECSHRIATETDQLGSEITEELGEQ*DQLECTKSRLVNTSENLSNSRKILRSMSRKVTTNKLLLS

Parental  IIILLELAILGGLVYYKFFRSH
          IIILL.LAILGGLVYYK.F..H
Retrocopy IIILLLLAILGGLVYYKLFHNH

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain	0.00 RPM	47.51 RPM
SRP007412_brain_prefrontal_cortex	0.00 RPM	57.91 RPM
SRP007412_cerebellum	0.13 RPM	26.60 RPM
SRP007412_heart	0.00 RPM	30.21 RPM
SRP007412_kidney	0.00 RPM	34.39 RPM
SRP007412_liver	0.00 RPM	13.26 RPM
SRP007412_testis	0.00 RPM	24.54 RPM

ChIP-Seq

Macaca mulatta was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_mmul_1420 retrocopy.

TSS

Macaca mulatta was not studied using FANTOM5 data.

Lab

retro_mmul_1420 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_mmul_1420 has 3 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Homo sapiens	retro_hsap_2682
Gorilla gorilla	retro_ggor_1871
Pongo abelii	retro_pabe_2298

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Parental genes homology:

Parental genes homology involve 18 parental genes, and 38 retrocopies.

Species	Parental gene accession	Retrocopies number
Callithrix jacchus	ENSCJAG00000015263	1 retrocopy	retro_cjac_1439,
Dasypus novemcinctus	ENSDNOG00000003643	2 retrocopies	retro_dnov_1503, retro_dnov_2031,
Dipodomys ordii	ENSDORG00000015939	2 retrocopies	retro_dord_52, retro_dord_716,
Echinops telfairi	ENSETEG00000006101	1 retrocopy	retro_etel_783,
Felis catus	ENSFCAG00000014090	1 retrocopy	retro_fcat_1855,
Homo sapiens	ENSG00000100568	3 retrocopies	retro_hsap_1002, retro_hsap_2682, retro_hsap_3013,
Gorilla gorilla	ENSGGOG00000005620	2 retrocopies	retro_ggor_1871, retro_ggor_797,
Macropus eugenii	ENSMEUG00000004910	2 retrocopies	retro_meug_499, retro_meug_697,
Microcebus murinus	ENSMICG00000010843	1 retrocopy	retro_mmur_849,
Myotis lucifugus	ENSMLUG00000011184	3 retrocopies	retro_mluc_1299, retro_mluc_2393, retro_mluc_781,
Macaca mulatta	ENSMMUG00000015866	1 retrocopy	retro_mmul_1420 ,
Mustela putorius furo	ENSMPUG00000007130	1 retrocopy	retro_mputfur_1516,
Nomascus leucogenys	ENSNLEG00000000780	4 retrocopies	retro_nleu_1184, retro_nleu_2241, retro_nleu_231, retro_nleu_83,
Pongo abelii	ENSPPYG00000005927	5 retrocopies	retro_pabe_2298, retro_pabe_2498, retro_pabe_2602, retro_pabe_845, retro_pabe_974,
Pan troglodytes	ENSPTRG00000006468	3 retrocopies	retro_ptro_1808, retro_ptro_2037, retro_ptro_751,
Pteropus vampyrus	ENSPVAG00000011671	3 retrocopies	retro_pvam_132, retro_pvam_592, retro_pvam_797,
Tupaia belangeri	ENSTBEG00000003049	1 retrocopy	retro_tbel_3432,
Tarsius syrichta	ENSTSYG00000007688	2 retrocopies	retro_tsyr_1662, retro_tsyr_94,