RetrogeneDB ID: retro_hsap_3842

Retrocopy location

• Organism: Human (Homo sapiens)
• Coordinates: 7:46037141..46037670(-)
• Located in intron of: ENSG00000229628

Retrocopy information

• Ensembl ID: ENSG00000233952
• Aliases: None
• Status: KNOWN_PSEUDOGENE

Parental gene information

• Parental gene symbol: FTL
• Ensembl ID: ENSG00000087086
• Aliases: FTL, LFTD, NBIA3
• Description: ferritin, light polypeptide [Source:HGNC Symbol;Acc:3999]

Sequence

>retro_hsap_3842
ATGAGCTCCCAGATTTATCAGAATTATTCCATTGAGGTGGAGGCAGCCATCAACCACCTGGTCAATTTGTACTTGTGGAT
CTTCTAAACCTATTTCTCTCTGGGCTTCTATTTTGACCATGATGATGTGGCTCTGGAAGGCATGGGCCACTTCTGCAAAT
CAGCTGAGGAGAAGCATGAGAGCACCGAGCATCGCTCAAAGATACAAAACCAGTGTGGCAGCATGCTGTCTTCCAGGACA
TCCAGAAACCGGCTCAAGATAAGTGGGGTACAACTTTGGATGCCATGGAAGCCACAATGCCCTTGGAGAAAAATCTGAAC
TAGGCCATTTTGGATCTTCATGCCCTCAGTTCTGGCTACACAGATCCCCATCTCTGTGACTTCCTGGAGAGTCACTTCCT
AGATGAGGAAGTTAAACTCATCAAGAAGATGGGTGACCACCTGACCAACCTCCACAGGCTGCACAGGCTGGCTGGCCTGG
AGGCTGGGCTGGCGAGTATCTCTTTGAAAGGCTCACCTTCAAGTACAAC

Alignment

ORF - retro_hsap_3842 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 70.56 %
• Parental protein coverage: 100. %
• Number of stop codons detected: 2
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKREGYERLLKMQ
          MSSQI.QNYS..VEAA.N.LVNLYL....TY.SLGFYFD.DDVALEG..HF....AEEK.E..E...K.Q
Retrocopy MSSQIYQNYSIEVEAAINHLVNLYLWIF*TYFSLGFYFDHDDVALEGMGHFCKS-AEEKHESTEHRSKIQ

Parental  NQRGG-RALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSARTDPHLCDFLETHFLDEEV
          NQ.G...A.FQDI.KPA.D.WG.T.DAM.A.M.LEK.LN.A.LDLHAL.S..TDPHLCDFLE.HFLDEEV
Retrocopy NQCGS<HAVFQDIQKPAQDKWGTTLDAMEATMPLEKNLN*AILDLHALSSGYTDPHLCDFLESHFLDEEV

Parental  KLIKKMGDHLTNLHRL---GGPEAGL-GEYLFERLTLKHD
          KLIKKMGDHLTNLHRL....G.EAGL.GEYLFERLT.K..
Retrocopy KLIKKMGDHLTNLHRLHRLAGLEAGL<GEYLFERLTFKYN

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
bodymap2_adipose	0.00 RPM	1863.91 RPM
bodymap2_adrenal	0.00 RPM	1058.95 RPM
bodymap2_brain	0.00 RPM	272.02 RPM
bodymap2_breast	0.04 RPM	1738.93 RPM
bodymap2_colon	0.00 RPM	670.92 RPM
bodymap2_heart	0.04 RPM	243.78 RPM
bodymap2_kidney	0.00 RPM	1729.69 RPM
bodymap2_liver	0.00 RPM	2015.73 RPM
bodymap2_lung	0.00 RPM	2849.70 RPM
bodymap2_lymph_node	0.16 RPM	1616.52 RPM
bodymap2_ovary	0.00 RPM	779.67 RPM
bodymap2_prostate	0.00 RPM	1402.23 RPM
bodymap2_skeletal_muscle	0.09 RPM	372.14 RPM
bodymap2_testis	0.02 RPM	363.05 RPM
bodymap2_thyroid	0.04 RPM	908.10 RPM
bodymap2_white_blood_cells	0.00 RPM	1684.33 RPM

ChIP-Seq

RNA Polymerase II actvity near the 5' end of retro_hsap_3842 was not detected

EST

No EST(s) were mapped for retro_hsap_3842 retrocopy.

TSS

No TSS is located nearby retro_hsap_3842 retrocopy 5' end.

Lab

retro_hsap_3842 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_hsap_3842 has 2 orthologous retrocopies within eutheria group .

Species	RetrogeneDB ID
Pan troglodytes	retro_ptro_2619
Macaca mulatta	retro_mmul_1617

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Parental genes homology:

Parental genes homology involve 23 parental genes, and 309 retrocopies.

Species	Parental gene accession	Retrocopies number
Bos taurus	ENSBTAG00000013343	33 retrocopies	retro_btau_1007, retro_btau_1011, retro_btau_1033, retro_btau_1197, retro_btau_1209, retro_btau_1277, retro_btau_1354, retro_btau_1396, retro_btau_1452, retro_btau_1464, retro_btau_1466, retro_btau_1481, retro_btau_1511, retro_btau_1540, retro_btau_1561, retro_btau_1683, retro_btau_1781, retro_btau_1798, retro_btau_1848, retro_btau_250, retro_btau_301, retro_btau_339, retro_btau_340, retro_btau_419, retro_btau_422, retro_btau_520, retro_btau_597, retro_btau_639, retro_btau_649, retro_btau_938, retro_btau_963, retro_btau_993, retro_btau_998,
Canis familiaris	ENSCAFG00000003861	1 retrocopy	retro_cfam_203,
Callithrix jacchus	ENSCJAG00000000250	13 retrocopies	retro_cjac_1171, retro_cjac_1208, retro_cjac_1264, retro_cjac_1643, retro_cjac_2272, retro_cjac_2780, retro_cjac_3113, retro_cjac_3254, retro_cjac_3879, retro_cjac_556, retro_cjac_60, retro_cjac_889, retro_cjac_997,
Cavia porcellus	ENSCPOG00000020558	1 retrocopy	retro_cpor_100,
Dasypus novemcinctus	ENSDNOG00000002455	9 retrocopies	retro_dnov_1096, retro_dnov_1135, retro_dnov_1177, retro_dnov_1737, retro_dnov_2006, retro_dnov_2352, retro_dnov_2678, retro_dnov_473, retro_dnov_993,
Dasypus novemcinctus	ENSDNOG00000004126	5 retrocopies	retro_dnov_1263, retro_dnov_1490, retro_dnov_1760, retro_dnov_2329, retro_dnov_299,
Dasypus novemcinctus	ENSDNOG00000005577	36 retrocopies	retro_dnov_103, retro_dnov_1164, retro_dnov_1215, retro_dnov_130, retro_dnov_1382, retro_dnov_1441, retro_dnov_1515, retro_dnov_1568, retro_dnov_1657, retro_dnov_1812, retro_dnov_1815, retro_dnov_1918, retro_dnov_1991, retro_dnov_2014, retro_dnov_2134, retro_dnov_2187, retro_dnov_236, retro_dnov_2376, retro_dnov_2379, retro_dnov_247, retro_dnov_2575, retro_dnov_2658, retro_dnov_2667, retro_dnov_285, retro_dnov_305, retro_dnov_432, retro_dnov_439, retro_dnov_543, retro_dnov_598, retro_dnov_642, retro_dnov_807, retro_dnov_841, retro_dnov_846, retro_dnov_849, retro_dnov_861, retro_dnov_897,
Dasypus novemcinctus	ENSDNOG00000007848	2 retrocopies	retro_dnov_1049, retro_dnov_1476,
Dasypus novemcinctus	ENSDNOG00000016683	8 retrocopies	retro_dnov_1134, retro_dnov_1329, retro_dnov_2023, retro_dnov_2194, retro_dnov_2228, retro_dnov_56, retro_dnov_757, retro_dnov_886,
Felis catus	ENSFCAG00000003348	37 retrocopies	retro_fcat_101, retro_fcat_1029, retro_fcat_1040, retro_fcat_1059, retro_fcat_1141, retro_fcat_1150, retro_fcat_1295, retro_fcat_1319, retro_fcat_1336, retro_fcat_1359, retro_fcat_139, retro_fcat_1522, retro_fcat_1523, retro_fcat_1602, retro_fcat_1658, retro_fcat_1741, retro_fcat_1747, retro_fcat_1764, retro_fcat_1765, retro_fcat_1766, retro_fcat_1799, retro_fcat_1812, retro_fcat_1901, retro_fcat_297, retro_fcat_298, retro_fcat_315, retro_fcat_343, retro_fcat_50, retro_fcat_533, retro_fcat_536, retro_fcat_620, retro_fcat_675, retro_fcat_68, retro_fcat_778, retro_fcat_918, retro_fcat_927, retro_fcat_964,
Homo sapiens	ENSG00000087086	11 retrocopies	retro_hsap_1647, retro_hsap_1955, retro_hsap_2407, retro_hsap_2484, retro_hsap_2942, retro_hsap_3842 , retro_hsap_4146, retro_hsap_431, retro_hsap_4665, retro_hsap_4805, retro_hsap_929,
Homo sapiens	ENSG00000167996	20 retrocopies	retro_hsap_1243, retro_hsap_139, retro_hsap_1432, retro_hsap_2240, retro_hsap_2351, retro_hsap_2662, retro_hsap_2835, retro_hsap_2985, retro_hsap_2996, retro_hsap_316, retro_hsap_3208, retro_hsap_3293, retro_hsap_3589, retro_hsap_4083, retro_hsap_4232, retro_hsap_4671, retro_hsap_484, retro_hsap_81, retro_hsap_87, retro_hsap_898,
Gorilla gorilla	ENSGGOG00000011999	9 retrocopies	retro_ggor_128, retro_ggor_1547, retro_ggor_2039, retro_ggor_25, retro_ggor_2784, retro_ggor_2894, retro_ggor_420, retro_ggor_677, retro_ggor_750,
Loxodonta africana	ENSLAFG00000031248	11 retrocopies	retro_lafr_1003, retro_lafr_1064, retro_lafr_1065, retro_lafr_1069, retro_lafr_1206, retro_lafr_255, retro_lafr_345, retro_lafr_346, retro_lafr_785, retro_lafr_836, retro_lafr_977,
Macaca mulatta	ENSMMUG00000003909	9 retrocopies	retro_mmul_1051, retro_mmul_1125, retro_mmul_1508, retro_mmul_1569, retro_mmul_1617, retro_mmul_1950, retro_mmul_481, retro_mmul_518, retro_mmul_989,
Mustela putorius furo	ENSMPUG00000003304	29 retrocopies	retro_mputfur_1012, retro_mputfur_1026, retro_mputfur_1133, retro_mputfur_1142, retro_mputfur_1150, retro_mputfur_1216, retro_mputfur_1222, retro_mputfur_1225, retro_mputfur_1238, retro_mputfur_1246, retro_mputfur_1268, retro_mputfur_1303, retro_mputfur_1335, retro_mputfur_1521, retro_mputfur_1620, retro_mputfur_195, retro_mputfur_222, retro_mputfur_265, retro_mputfur_350, retro_mputfur_356, retro_mputfur_368, retro_mputfur_482, retro_mputfur_66, retro_mputfur_702, retro_mputfur_741, retro_mputfur_80, retro_mputfur_820, retro_mputfur_906, retro_mputfur_952,
Mus musculus	ENSMUSG00000050708	1 retrocopy	retro_mmus_228,
Nomascus leucogenys	ENSNLEG00000004716	10 retrocopies	retro_nleu_1099, retro_nleu_1332, retro_nleu_1871, retro_nleu_1977, retro_nleu_2028, retro_nleu_2180, retro_nleu_2294, retro_nleu_2715, retro_nleu_272, retro_nleu_290,
Oryctolagus cuniculus	ENSOCUG00000000014	6 retrocopies	retro_ocun_1090, retro_ocun_1627, retro_ocun_223, retro_ocun_357, retro_ocun_530, retro_ocun_982,
Pan troglodytes	ENSPTRG00000011268	11 retrocopies	retro_ptro_1118, retro_ptro_1307, retro_ptro_1437, retro_ptro_2055, retro_ptro_2619, retro_ptro_2818, retro_ptro_3101, retro_ptro_3195, retro_ptro_328, retro_ptro_645, retro_ptro_98,
Rattus norvegicus	ENSRNOG00000020843	7 retrocopies	retro_rnor_109, retro_rnor_168, retro_rnor_263, retro_rnor_306, retro_rnor_362, retro_rnor_373, retro_rnor_4,
Sus scrofa	ENSSSCG00000003153	33 retrocopies	retro_sscr_1040, retro_sscr_1095, retro_sscr_1101, retro_sscr_1142, retro_sscr_1189, retro_sscr_1214, retro_sscr_1215, retro_sscr_124, retro_sscr_197, retro_sscr_212, retro_sscr_224, retro_sscr_305, retro_sscr_331, retro_sscr_400, retro_sscr_531, retro_sscr_532, retro_sscr_533, retro_sscr_534, retro_sscr_535, retro_sscr_536, retro_sscr_559, retro_sscr_589, retro_sscr_605, retro_sscr_74, retro_sscr_747, retro_sscr_799, retro_sscr_817, retro_sscr_830, retro_sscr_833, retro_sscr_839, retro_sscr_840, retro_sscr_862, retro_sscr_898,
Ictidomys tridecemlineatus	ENSSTOG00000020639	7 retrocopies	retro_itri_1606, retro_itri_1701, retro_itri_1857, retro_itri_24, retro_itri_355, retro_itri_719, retro_itri_741,

Population studies

Expression level across human populations :

Library	Retrogene expression
CEU_NA11831	0.06 RPM
CEU_NA11843	0.00 RPM
CEU_NA11930	0.03 RPM
CEU_NA12004	0.00 RPM
CEU_NA12400	0.00 RPM
CEU_NA12751	0.00 RPM
CEU_NA12760	0.00 RPM
CEU_NA12827	0.00 RPM
CEU_NA12872	0.03 RPM
CEU_NA12873	0.00 RPM
FIN_HG00183	0.00 RPM
FIN_HG00277	0.00 RPM
FIN_HG00315	0.00 RPM
FIN_HG00321	0.03 RPM
FIN_HG00328	0.00 RPM
FIN_HG00338	0.00 RPM
FIN_HG00349	0.00 RPM
FIN_HG00375	0.00 RPM
FIN_HG00377	0.00 RPM
FIN_HG00378	0.00 RPM
GBR_HG00099	0.00 RPM
GBR_HG00111	0.00 RPM
GBR_HG00114	0.00 RPM
GBR_HG00119	0.00 RPM
GBR_HG00131	0.00 RPM
GBR_HG00133	0.00 RPM
GBR_HG00134	0.00 RPM
GBR_HG00137	0.00 RPM
GBR_HG00142	0.08 RPM
GBR_HG00143	0.00 RPM
TSI_NA20512	0.00 RPM
TSI_NA20513	0.00 RPM
TSI_NA20518	0.00 RPM
TSI_NA20532	0.03 RPM
TSI_NA20538	0.00 RPM
TSI_NA20756	0.00 RPM
TSI_NA20765	0.02 RPM
TSI_NA20771	0.00 RPM
TSI_NA20786	0.00 RPM
TSI_NA20798	0.00 RPM
YRI_NA18870	0.00 RPM
YRI_NA18907	0.00 RPM
YRI_NA18916	0.00 RPM
YRI_NA19093	0.00 RPM
YRI_NA19099	0.00 RPM
YRI_NA19114	0.00 RPM
YRI_NA19118	0.00 RPM
YRI_NA19213	0.00 RPM
YRI_NA19214	0.00 RPM
YRI_NA19223	0.02 RPM

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Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).