RetrogeneDB ID:

retro_hsap_2350

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:2:178861978..178863497(-)
Located in intron of:ENSG00000128655
Retrocopy
information
Ensembl ID:ENSG00000213962
Aliases:None
Status:KNOWN_PSEUDOGENE
Parental gene
information
Parental gene summary:
Parental gene symbol:API5
Ensembl ID:ENSG00000166181
Aliases:API5, AAC-11, AAC11
Description:apoptosis inhibitor 5 [Source:HGNC Symbol;Acc:594]


Retrocopy-Parental alignment summary:






>retro_hsap_2350
ATGCCGATGGTAGAGGAGCTTTACGGCAACTATGGCATCATGGCCGATACCACGGAGCGAGTGGGCCAGCATAAAGATGC
CTATCAAGTGATACTGGATGGTGTGAAAGGTGGTACTAAGGAAAAACGATTAGCAGCTCAATTTATTCTGAAATTCTTTA
AGCATTTTACAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAAGATGAAGATGTATCTATTTGACGT
CAAGCAATTAAAGAACTGCCTCAATTTACCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAATGCAACTTTTGGA
GTCAGATGGCTCTGCAGAATTTAACCTAGTGAACAATGCCCTGTTGAGTATATTTAACATGGATGGAAAAGGGACTTTAG
GTTCATTGTTCAGCCAAATACTTCAAGGAGAGGACATTGTTAGAGAATGAGCAATTAAATTCCTTTCTACAAAACTTAAG
ACTTTACCAGATGAAGTATTAACAAAGGAAGTGGAAGAGCTTATACTAACTGAATCCAAACACGTCCTAGAAGATGTGAC
TCATGAAGAATTTGTTCTATTCATGAATTACTGTCTGGGTTAAAAAGCTTACAGACAGTAAGTGGAAGACAGCAACTTGT
AAAGTTGGTGGCTGAACAGGCCGACCTAGAACAGACCTTCAATCCCTCAGATCCTGAGTGTGTGGGCAGGCTCTTACAGT
GCACTCAGCAGGCAGTACCCTTCTTCTCTAAAACTGTCCATTCCACAAGGTCTGTGACATATTTCTGTGAGCAGGTTCTC
CCTAACCTTGGTATCTTGACTACCGCAGTGGAAGGTCTTGACATACAGTTGGAGGTATTGAAATTGTTGGTGGAGATGAG
TTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAGGGAAACTATTTGATAAGTTATTGGAATACATGCCCCTCC
CTCCAGAAGAAGCAGAAAATGGAGGGAATGCTGGTGATGAAGAACCCAAACTACAGTTCAGTTATGTGGAATGTTTGTTG
TACAGTTTTCACCAGTTGGGCCAAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAACTCAAAGATTTCAA
AATCAGGCTGCAATACTTTGCACGAGGCCTGCAAGTTTATATCAGACAACTTCACTTAGCTCTCCAGGTGAAACAGGTGA
GAACAGAAAAGAACAGAAAACAGAAGAGAACAAAATTAAAGTTGTTGCATTGAAAGCAACAAACAATATCAATGTTTTAA
TCAAGGATCTCTTCCACATTCCTCCTTCTTGTAAGAGCACAGTAACACTATCCTGGAAACCTGTATAAAAGGTTGAGATT
GGGCAAAAGAGAGCCAGTGAATATACAACTTCAGGTTCACCACCCCAGAAATCTTCAGCAGAACAAAAAAGAGATGCCAG
GCAGATTTATAATCCTCCCAGTGAGAAATATAGCAGCAATTTGGGCAACTTTAATTATGAGAGGAGCCTTCAGGGAAAG

ORF - retro_hsap_2350 Open Reading Frame is not conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 89.78 %
Parental protein coverage: 100. %
Number of stop codons detected: 3
Number of frameshifts detected 2


Retrocopy - Parental Gene Alignment:

ParentalMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDL
MP.VEELY.NYGI.AD.TE.VGQHKDAYQVILDGVKGGTKEKRLAAQFI.KFFKHF.ELADSAINAQLDL
RetrocopyMPMVEELYGNYGIMADTTERVGQHKDAYQVILDGVKGGTKEKRLAAQFILKFFKHFTELADSAINAQLDL
ParentalCEDEDVSIRRQAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQI
CEDEDVSI.RQAIKELPQF.TGENLPRVADIL.QLL..D.SAEFNLVNNALLSIF.MD.KGTLG.LFSQI
RetrocopyCEDEDVSI*RQAIKELPQFTTGENLPRVADILMQLLESDGSAEFNLVNNALLSIFNMDGKGTLGSLFSQI
ParentalLQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFM-KILSGLKSLQTVSG
LQGEDIVRE.AIKFLSTKLKTLPDEVLTKEVEELILTESK.VLEDVT.EEFVLFM...LSGLKSLQTVSG
RetrocopyLQGEDIVRE*AIKFLSTKLKTLPDEVLTKEVEELILTESKHVLEDVTHEEFVLFM<ELLSGLKSLQTVSG
ParentalRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLGTLTTPVEG
RQQLV.LVAEQADLEQTFNPSDP.CV.RLLQCT.QAVP.FSK.VHSTR.VTYFCEQVLPNLG.LTT.VEG
RetrocopyRQQLVKLVAEQADLEQTFNPSDPECVGRLLQCTQQAVPFFSKTVHSTRSVTYFCEQVLPNLGILTTAVEG
ParentalLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYS
LDIQLEVLKLL.EMSSFCGDMEKLETNL.KLFDKLLEYMPLPPEEAENG.NAG.EEPKLQFSYVECLLYS
RetrocopyLDIQLEVLKLLVEMSSFCGDMEKLETNLGKLFDKLLEYMPLPPEEAENGGNAGDEEPKLQFSYVECLLYS
ParentalFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQ-GKTGEALK---TEENKIKVVAL
FHQLG.KLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQL.LALQ.G.TGE..K...TEENKIKVVAL
RetrocopyFHQLGQKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLHLALQ<GETGENRKEQKTEENKIKVVAL
ParentalKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPS
K.TNNINVLIKDLFHIPPS.KSTVTLSWKPV.KVEIGQKRASE.TTSGSPP.KSSA..KRDARQIYNPPS
RetrocopyKATNNINVLIKDLFHIPPSCKSTVTLSWKPV*KVEIGQKRASEYTTSGSPPQKSSAEQKRDARQIYNPPS
ParentalGKYSSNLGNFNYERSLQGK
.KYSSNLGNFNYERSLQGK
RetrocopyEKYSSNLGNFNYERSLQGK

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 0 .00 RPM 91 .62 RPM
bodymap2_adrenal 0 .00 RPM 98 .66 RPM
bodymap2_brain 0 .00 RPM 138 .51 RPM
bodymap2_breast 0 .00 RPM 80 .31 RPM
bodymap2_colon 0 .00 RPM 120 .50 RPM
bodymap2_heart 0 .00 RPM 43 .05 RPM
bodymap2_kidney 0 .06 RPM 120 .96 RPM
bodymap2_liver 0 .02 RPM 63 .65 RPM
bodymap2_lung 0 .00 RPM 71 .01 RPM
bodymap2_lymph_node 0 .00 RPM 96 .56 RPM
bodymap2_ovary 0 .00 RPM 119 .56 RPM
bodymap2_prostate 0 .00 RPM 114 .04 RPM
bodymap2_skeletal_muscle 0 .00 RPM 51 .00 RPM
bodymap2_testis 0 .00 RPM 95 .10 RPM
bodymap2_thyroid 0 .00 RPM 144 .59 RPM
bodymap2_white_blood_cells 0 .00 RPM 156 .10 RPM

ChIP-Seq - click to see more details

RNA Polymerase II actvity near the 5' end of retro_hsap_2350 was not detected

EST - click to see more details

1 EST(s) were mapped to retro_hsap_2350 retrocopy
EST ID Start End Identity Match Mis-match Score
AA668659 178862785 178863171 99.5 383 2 380

TSS - click to see more details

No TSS is located nearby retro_hsap_2350 retrocopy 5' end.

Lab - click to see more details

retro_hsap_2350 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_2350 has 3 orthologous retrocopies within eutheria group .

Species RetrogeneDB ID
Pan troglodytes retro_ptro_1720
Gorilla gorilla retro_ggor_1784
Macaca mulatta retro_mmul_947
Parental genes homology:
Parental genes homology involve 5 parental genes, and 8 retrocopies.

Species Parental gene accession Retrocopies number
Homo sapiens ENSG00000166181 2 retrocopies
retro_hsap_2350 , retro_hsap_4893,
Gorilla gorilla ENSGGOG000000023582 retrocopies
retro_ggor_1784, retro_ggor_3055,
Myotis lucifugus ENSMLUG000000135461 retrocopy
retro_mluc_245,
Nomascus leucogenys ENSNLEG000000179561 retrocopy
retro_nleu_352,
Pan troglodytes ENSPTRG000000035162 retrocopies
retro_ptro_1720, retro_ptro_3261,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) > 0 RPM = 0.04 RPM Legend:


Library Retrogene expression
CEU_NA11831 0 .00 RPM
CEU_NA11843 0 .00 RPM
CEU_NA11930 0 .00 RPM
CEU_NA12004 0 .00 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .02 RPM
CEU_NA12760 0 .00 RPM
CEU_NA12827 0 .00 RPM
CEU_NA12872 0 .03 RPM
CEU_NA12873 0 .00 RPM
FIN_HG00183 0 .03 RPM
FIN_HG00277 0 .00 RPM
FIN_HG00315 0 .00 RPM
FIN_HG00321 0 .00 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .00 RPM
FIN_HG00349 0 .03 RPM
FIN_HG00375 0 .00 RPM
FIN_HG00377 0 .00 RPM
FIN_HG00378 0 .00 RPM
GBR_HG00099 0 .03 RPM
GBR_HG00111 0 .04 RPM
GBR_HG00114 0 .00 RPM
GBR_HG00119 0 .00 RPM
GBR_HG00131 0 .00 RPM
GBR_HG00133 0 .00 RPM
GBR_HG00134 0 .00 RPM
GBR_HG00137 0 .00 RPM
GBR_HG00142 0 .03 RPM
GBR_HG00143 0 .00 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .00 RPM
TSI_NA20518 0 .03 RPM
TSI_NA20532 0 .03 RPM
TSI_NA20538 0 .00 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .00 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .00 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .00 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .00 RPM
YRI_NA19093 0 .00 RPM
YRI_NA19099 0 .00 RPM
YRI_NA19114 0 .00 RPM
YRI_NA19118 0 .00 RPM
YRI_NA19213 0 .00 RPM
YRI_NA19214 0 .00 RPM
YRI_NA19223 0 .00 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).





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