RetrogeneDB ID:

retro_hsap_1473

Retrocopy
location
Organism:Human (Homo sapiens)
Coordinates:15:30515571..30517371(+)
Located in intron of:None
Retrocopy
information
Ensembl ID:ENSG00000259993
Aliases:None
Status:KNOWN_PSEUDOGENE
Parental gene
information
Parental gene summary:
Parental gene symbol:HCN2
Ensembl ID:ENSG00000099822
Aliases:HCN2, BCNG-2, BCNG2, HAC-1
Description:hyperpolarization activated cyclic nucleotide-gated potassium channel 2 [Source:HGNC Symbol;Acc:4846]


Retrocopy-Parental alignment summary:






>retro_hsap_1473
CCGCGCCGCAGCCGGGCCAGCTTCATGCAGCGCCACTTCGGCGCGCTCCTGCAGCTGGGCGTCAACAAGTTCTCGCTGCG
GATGTTCGGCAGCCAGAAGGCCGTGGAGCGCGAGCAGGAGCGCGTCCAGTCAGCGGGGTCCTGGATCATCCACCCGTACA
GCGACTTCAGGTTCTACTGGGACTTCACCATGCTGCTGTTCATGGTGGGAAACCTCATCATCATCCCAGTGGGCATCACC
TTCTTCAAGGACGAGACCACTGCCCTGTGGATCGTGTTCAACGTGGTCTCGGACACCTTCTGCCTCATGGACCTGGTGTT
GAACTTCCGCACCGGCATTGTGATCGAGGACAACACGGAGATCATCCTGGACCAAGAGAAGATCAAGAAGTACGTGCGCA
CGTGGTTCATGGTGGACTTCGTGTCCTCCATCCCCGTGGACTACATCTTCCTCATCGTGGAGAAGGGCATCGACTCCGAG
GTCTACAAGACGGCGTGCGCCCTGCGGATCGTGCGCTTCACCAAGATCCTCAGCCTCCTGCGGCTGCTGCGCCTCTCGCG
CCTGATCCGCTACATCCACCAGTGGGAGGAGATCTTCCACATGACCTATGACCTGGCCAGCGCGGTGATGCGGTTCTGCA
ACCTCATCAGTATGATGCTGCTGCTCTGCCACTGGGATGGCTGCCTGCAGTTCCTGGTGGCCATGCTGCAGGACTTCCCG
TGCAACTGCTGGGTGTCCATCAATGGCATGGTGAACCACTGGTGGAGCGAACTGTATTCCTTCGCACTCTTCAAGGCCAT
GAGCCACATGCTGTGCATTGGGTATGGCCGGCAGGCGCCCGAGAGCATGACGGACATCTGGCTGACCATGCTCAGCATGA
TTGTGAGTGACACCTGCTACGCCATGTTCATCGGCCACGCCACTGCCCTCATCCAGTCGCTGGACTCCTCGCGGCGCCAA
TACCAGAAGTACAAGCAGGTGGAGCAGTACATGTCCTTCCACAAGCTGCCGGCCGACTTCCGCCAGAAGATCCACGACTA
CTACGAGCACCGTTACCAGGGCAAGATGTTCGACGAGGACAGCATCCTGGGCGAGCTCAACGGGCCCCTGCGGGAGGAGA
TTGTCAACTTCAACTGCCGGAAGCTGGTGACCTCCATGCCGCTGTTCGCCAATGCTGACCCCAACTTCGTCACGGCCATG
CTGACCAAGCTCAAGTTCGAGGTCTTCCAGCCGGGTGACTACCTCATCCGCGAAGGCACCATCGGGAAGATGTACTTCAT
TCAGCACGGCGTGGTCAGCGTGCTCGCTAAGGGCAACAAGGAGATGAAGCTGTTCGATGGCTCCTACTTCGGAGAGATCT
GCCTGCTCACCCGGGGCCACCGCATGGCGAGCGTGCGGGCCAACACCTATTGCCGCCTCCTTTCGCTGAGCGTGGACAAC
TTCAACGAGGTGCTGGAGGAGTACCCCATGATGCGGCGCGCCTTCGAGACGGTGGCCATCGACCGCCTGGACCGCATCGG
CAAGAAGAATTCCATCCTCCTGCACAAGGTGCAGCATGACCTTAACTCGGGCGTATTCAACAACCAGTAGAACGCCATCA
TCCAGGAGATCGTCAAGTACGACGGCGAGATGGTGCAGCAGGCCGAGCTGGGTCAGCGCCTGGGCCTCTTCCCGCCGCCG
CCGCCGCCGCAGGTCACCTCGGCCATCGCCACGCTGCAGCAGGCCGTGGTCATGAGCTTCTGCCCGCAGGTGGCGCGGCC
GCTCGTGGGGCCGCTGGCGCTCGGCTCGCCGCGCCTCGTG

ORF - retro_hsap_1473 Open Reading Frame is not conserved.
Retrocopy - Parental Gene Alignment summary:
Percent Identity: 93.05 %
Parental protein coverage: 67.94 %
Number of stop codons detected: 1
Number of frameshifts detected 0


Retrocopy - Parental Gene Alignment:

ParentalPRGSQASFMQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVG
PR.S.ASFMQR.FGALLQ.GVNKFSLRMFGSQKAVEREQERV.SAG.WIIHPYSDFRFYWDFTMLLFMVG
RetrocopyPRRSRASFMQRHFGALLQLGVNKFSLRMFGSQKAVEREQERVQSAGSWIIHPYSDFRFYWDFTMLLFMVG
ParentalNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVD
NLIIIPVGITFFKDETTA.WIVFNVVSDTF.LMDLVLNFRTGIVIEDNTEIILD.EKIKK.Y.RTWF.VD
RetrocopyNLIIIPVGITFFKDETTALWIVFNVVSDTFCLMDLVLNFRTGIVIEDNTEIILDQEKIKK-YVRTWFMVD
ParentalFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAV
FVSSIPVDYIFLIVEKGIDSEVYKTA.ALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAV
RetrocopyFVSSIPVDYIFLIVEKGIDSEVYKTACALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAV
ParentalMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFKAMSHMLCIGYGRQA
MR.CNLISMMLLLCHWDGCLQFLV.MLQDFP.NCWVSINGMVNH.WSELYSFALFKAMSHMLCIGYGRQA
RetrocopyMRFCNLISMMLLLCHWDGCLQFLVAMLQDFPCNCWVSINGMVNHWWSELYSFALFKAMSHMLCIGYGRQA
ParentalPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYY
PESMTDIWLTMLSMIV..TCYAMFIGHATALIQSLDSSRRQYQ.KYKQVEQYMSFHKLPADFRQKIHDYY
RetrocopyPESMTDIWLTMLSMIVSDTCYAMFIGHATALIQSLDSSRRQYQ-KYKQVEQYMSFHKLPADFRQKIHDYY
ParentalEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIRE
EHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLV.SMPLFANADPNFVTAMLTKLKFEVFQPGDY.IRE
RetrocopyEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVTSMPLFANADPNFVTAMLTKLKFEVFQPGDYLIRE
ParentalGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEE
GTIG.KMYFIQHGVVSVL.KGNKEMKL.DGSYFGEICLLTRG.R.ASVRA.TYCRL.SLSVDNFNEVLEE
RetrocopyGTIG-KMYFIQHGVVSVLAKGNKEMKLFDGSYFGEICLLTRGHRMASVRANTYCRLLSLSVDNFNEVLEE
ParentalYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLF
YPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQ.NAIIQEIVKYD.EMVQQAELGQR.GLF
RetrocopyYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQ*NAIIQEIVKYDGEMVQQAELGQRLGLF
ParentalPPPPPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLV
........VTSAIATLQQA..MSFCPQVARPLVGPLALGSPRLV
Retrocopy-XXXXXXXVTSAIATLQQAVVMSFCPQVARPLVGPLALGSPRLV

Legend:
*Stop codon
>Forward frameshift by one nucleotide
<Reverse frameshift by one nucleotide






RNA-Seq - click to see more details

(Hint: click retrocopy or parental gene accession number on the plot's legend, to show / hide expression level values)

Expression validation based on RNA-Seq data:
Library Retrocopy expression Parental gene expression
bodymap2_adipose 0 .00 RPM 0 .20 RPM
bodymap2_adrenal 0 .00 RPM 0 .33 RPM
bodymap2_brain 0 .00 RPM 46 .32 RPM
bodymap2_breast 0 .00 RPM 0 .10 RPM
bodymap2_colon 0 .00 RPM 0 .60 RPM
bodymap2_heart 0 .00 RPM 7 .94 RPM
bodymap2_kidney 0 .00 RPM 1 .18 RPM
bodymap2_liver 0 .00 RPM 0 .08 RPM
bodymap2_lung 0 .00 RPM 0 .07 RPM
bodymap2_lymph_node 0 .00 RPM 1 .04 RPM
bodymap2_ovary 0 .00 RPM 0 .04 RPM
bodymap2_prostate 0 .00 RPM 0 .94 RPM
bodymap2_skeletal_muscle 0 .00 RPM 0 .00 RPM
bodymap2_testis 0 .11 RPM 7 .58 RPM
bodymap2_thyroid 0 .00 RPM 0 .02 RPM
bodymap2_white_blood_cells 0 .00 RPM 0 .93 RPM

ChIP-Seq - click to see more details

RNA Polymerase II actvity near the 5' end of retro_hsap_1473 was not detected

EST - click to see more details

No EST(s) were mapped for retro_hsap_1473 retrocopy.

TSS - click to see more details

No TSS is located nearby retro_hsap_1473 retrocopy 5' end.

Lab - click to see more details

retro_hsap_1473 was not experimentally validated.

Retrocopy orthology:
Retrocopy retro_hsap_1473 has 0 orthologous retrocopies within eutheria group .

Parental genes homology:
Parental genes homology involve 1 parental gene, and 2 retrocopies.

Species Parental gene accession Retrocopies number
Homo sapiens ENSG00000099822 2 retrocopies
retro_hsap_1473 , retro_hsap_1546,

Expression level across human populations :
image/svg+xml GBR_HG00142 GBR_HG00099 GBR_HG00114 GBR_HG00143 GBR_HG00131 GBR_HG00137 GBR_HG00133 GBR_HG00119 GBR_HG00111 GBR_HG00134 FIN_HG00378 FIN_HG00338 FIN_HG00349 FIN_HG00375 FIN_HG00315 FIN_HG00277 FIN_HG00328 FIN_HG00321 FIN_HG00377 FIN_HG00183 TSI_NA20756 TSI_NA20538 TSI_NA20798 TSI_NA20532 TSI_NA20765 TSI_NA20518 TSI_NA20513 TSI_NA20512 TSI_NA20771 TSI_NA20786 YRI_NA19114 YRI_NA19099 YRI_NA18870 YRI_NA18907 YRI_NA19223 YRI_NA19214 YRI_NA18916 YRI_NA19093 YRI_NA19118 YRI_NA19213 Toscaniin Italia: Finnish inFinland: British in England and Scotland: Utah Residents (CEPH) with Northernand Western European Ancestry: Yoruba in Ibadan, Nigeria: CEU_NA12760 CEU_NA12827 CEU_NA12872 CEU_NA12751 CEU_NA12873 CEU_NA12400 CEU_NA11930 CEU_NA12004 CEU_NA11831 CEU_NA11843 No expression ( = 0 RPM ) > 0 RPM = 0.03 RPM Legend:


Library Retrogene expression
CEU_NA11831 0 .00 RPM
CEU_NA11843 0 .00 RPM
CEU_NA11930 0 .00 RPM
CEU_NA12004 0 .00 RPM
CEU_NA12400 0 .00 RPM
CEU_NA12751 0 .02 RPM
CEU_NA12760 0 .00 RPM
CEU_NA12827 0 .00 RPM
CEU_NA12872 0 .00 RPM
CEU_NA12873 0 .03 RPM
FIN_HG00183 0 .00 RPM
FIN_HG00277 0 .00 RPM
FIN_HG00315 0 .00 RPM
FIN_HG00321 0 .00 RPM
FIN_HG00328 0 .00 RPM
FIN_HG00338 0 .00 RPM
FIN_HG00349 0 .00 RPM
FIN_HG00375 0 .00 RPM
FIN_HG00377 0 .00 RPM
FIN_HG00378 0 .00 RPM
GBR_HG00099 0 .00 RPM
GBR_HG00111 0 .00 RPM
GBR_HG00114 0 .00 RPM
GBR_HG00119 0 .00 RPM
GBR_HG00131 0 .00 RPM
GBR_HG00133 0 .00 RPM
GBR_HG00134 0 .00 RPM
GBR_HG00137 0 .00 RPM
GBR_HG00142 0 .00 RPM
GBR_HG00143 0 .00 RPM
TSI_NA20512 0 .00 RPM
TSI_NA20513 0 .00 RPM
TSI_NA20518 0 .00 RPM
TSI_NA20532 0 .00 RPM
TSI_NA20538 0 .00 RPM
TSI_NA20756 0 .00 RPM
TSI_NA20765 0 .00 RPM
TSI_NA20771 0 .00 RPM
TSI_NA20786 0 .00 RPM
TSI_NA20798 0 .00 RPM
YRI_NA18870 0 .00 RPM
YRI_NA18907 0 .00 RPM
YRI_NA18916 0 .00 RPM
YRI_NA19093 0 .00 RPM
YRI_NA19099 0 .00 RPM
YRI_NA19114 0 .00 RPM
YRI_NA19118 0 .00 RPM
YRI_NA19213 0 .00 RPM
YRI_NA19214 0 .00 RPM
YRI_NA19223 0 .00 RPM

Indel association:

No indels were associated with its genomic coordinates. Based on Kabza et al. 2015 (PubMed).





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