RetrogeneDB ID: retro_chof_1670

Retrocopy location

• Organism: Sloth (Choloepus hoffmanni)
• Coordinates: scaffold_35472:4784..5494(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: YWHAB
• Ensembl ID: ENSCHOG00000005782
• Aliases: None
• Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide [Source:HGNC Symbol;Acc:12849]

Sequence

>retro_chof_1670
AAAAATGAGTTCATGCAGAAAGCCAAACTGACAAAGCAGGTTGAGTGATATGATGACACAGCAGCCTGCATGAAGTCTGT
AAGTGAGCAGGGGGGCTGAATTACCCAATGCGGAGAGGAATCTTCTCTCAGTTTGCTTGCATAAGTTTTTCTATGTGCTC
GTAGGTCATCTTGGAGGATCATCTCAAGTATTGAGCAAAAGATAGAAGGTGCTGAGAAAAAGCAACTGATGGCTCAAGAA
CACAGAAAATTGTGACTGAGCTAAGAGATATCTGCAATGATTTACTGTCTCTCCTGTAAAAGTTCTTGATCCCCAGTGCC
TCACAAGCAGAGAGCAGTTTTCTATTTGAAAATGAAGGGAGACTATTATTATTACTTGTCCAAGGTTGCTGCTGGTGATG
CTAGGAATGGATTGTGGATCAGACACAACAAGTACACCAAGAAGCATTTGAAATCTGCAAAACAGAAATGCAACTAACAC
TTCCTATTAGATGGTGTCTAGCTCTGAACCTTTCTGTGTTCTATTATGAGATTCTGAACTCCCTGGAGAAAGCTTGCTCT
CTTACAAAGACAGCTTTTGATAATGCCATTGCTGAACTTGATACATTAAGTGGAGAGTCATACAAAGACATAATAATGCA
ATTACTGAAAGACAACTTGACATTGTGGACATTGGATACCCAAGGAGACAAAACTGAAGCAGGAGAAGGA

Alignment

ORF - retro_chof_1670 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 59.43 %
• Parental protein coverage: 97.56 %
• Number of stop codons detected: 4
• Number of frameshifts detected: 3

Retrocopy - Parental Gene Alignment:

Parental  KSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSN-KERNLLSVSYKNVVGARRSSWRVISSIEQKTER
          K.E..QKAKL..Q.E.YDD.AA.MK.V.EQG.......E...LS........ARRSSWR.ISSIEQK.E.
Retrocopy KNEFMQKAKLTKQVE*YDDTAACMKSVSEQGG*ITQCGEESSLSLLA*VFLCARRSSWRIISSIEQKIEG

Parental  NEKKQQMGKEYR-EKIEAELQDICNDVLELLDKYLIPNATQPESKVFYLKMKG-DYFRYLSEVASGDSK-
          .E.K.Q........KI..EL.DICND.L.LL.K.LIP.A.Q.ES..F.....G.DY..YLS.VA.GD...
Retrocopy AE-KKQLMAQEH<QKIVTELRDICNDLLSLL*KFLIPSASQAESS-FLFENEG>DYYYYLSKVAAGDAR<

Parental  QTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNE
          ...V...QQ..QEAFEI.K.EMQ.T.PIR..LALN.SVFYYEILNS.EKACSL.KTAFD.AIAELDTL..
Retrocopy EWIVDQTQQVHQEAFEICKTEMQLTLPIRWCLALNLSVFYYEILNSLEKACSLTKTAFDNAIAELDTLSG

Parental  ESYKDSTLIMQLLRDNLTXXTSETQGDEREAGGG
          ESYKD...IMQLL.DNLT..T..TQGD..EAG.G
Retrocopy ESYKD--IIMQLLKDNLTLWTLDTQGDKTEAGEG

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Choloepus hoffmanni was not studied using RNA-Seq expression data.

ChIP-Seq

Choloepus hoffmanni was not studied using ChIP-Seq data.

EST

Choloepus hoffmanni was not studied using EST data.

TSS

Choloepus hoffmanni was not studied using FANTOM5 data.

Lab

retro_chof_1670 was not experimentally validated.

Homology

Retrocopy orthology:

Choloepus hoffmanni does not belong to any of the species groups (eutheria, teleost or neognath), studied for retrocopy-based homology. For more information about studied groups, please go to help section.

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Parental genes homology:

Parental genes homology involve 28 parental genes, and 163 retrocopies.

Species	Parental gene accession	Retrocopies number
Anolis carolinensis	ENSACAG00000011796	1 retrocopy	retro_acar_8,
Choloepus hoffmanni	ENSCHOG00000002798	9 retrocopies	retro_chof_1572, retro_chof_1703, retro_chof_1890, retro_chof_2321, retro_chof_2346, retro_chof_2669, retro_chof_292, retro_chof_315, retro_chof_933,
Choloepus hoffmanni	ENSCHOG00000004661	13 retrocopies	retro_chof_136, retro_chof_1427, retro_chof_1605, retro_chof_1835, retro_chof_2026, retro_chof_2115, retro_chof_2134, retro_chof_2233, retro_chof_429, retro_chof_481, retro_chof_489, retro_chof_527, retro_chof_863,
Choloepus hoffmanni	ENSCHOG00000005782	15 retrocopies	retro_chof_1049, retro_chof_1325, retro_chof_1630, retro_chof_1670 , retro_chof_1975, retro_chof_22, retro_chof_2221, retro_chof_2350, retro_chof_2423, retro_chof_2619, retro_chof_326, retro_chof_352, retro_chof_487, retro_chof_707, retro_chof_971,
Choloepus hoffmanni	ENSCHOG00000010861	2 retrocopies	retro_chof_1912, retro_chof_905,
Callithrix jacchus	ENSCJAG00000017664	2 retrocopies	retro_cjac_1002, retro_cjac_2214,
Dipodomys ordii	ENSDORG00000001064	14 retrocopies	retro_dord_235, retro_dord_236, retro_dord_255, retro_dord_256, retro_dord_258, retro_dord_259, retro_dord_262, retro_dord_263, retro_dord_332, retro_dord_442, retro_dord_545, retro_dord_681, retro_dord_725, retro_dord_9,
Echinops telfairi	ENSETEG00000009967	4 retrocopies	retro_etel_1221, retro_etel_1380, retro_etel_1536, retro_etel_1705,
Homo sapiens	ENSG00000166913	4 retrocopies	retro_hsap_4160, retro_hsap_4841, retro_hsap_622, retro_hsap_855,
Gorilla gorilla	ENSGGOG00000004580	2 retrocopies	retro_ggor_2795, retro_ggor_699,
Microcebus murinus	ENSMICG00000000973	7 retrocopies	retro_mmur_1044, retro_mmur_1100, retro_mmur_1288, retro_mmur_1576, retro_mmur_27, retro_mmur_305, retro_mmur_979,
Myotis lucifugus	ENSMLUG00000006319	1 retrocopy	retro_mluc_871,
Macaca mulatta	ENSMMUG00000013206	3 retrocopies	retro_mmul_1061, retro_mmul_236, retro_mmul_673,
Monodelphis domestica	ENSMODG00000016200	2 retrocopies	retro_mdom_1557, retro_mdom_212,
Nomascus leucogenys	ENSNLEG00000006643	2 retrocopies	retro_nleu_42, retro_nleu_422,
Oryctolagus cuniculus	ENSOCUG00000003002	1 retrocopy	retro_ocun_273,
Otolemur garnettii	ENSOGAG00000008909	3 retrocopies	retro_ogar_122, retro_ogar_1243, retro_ogar_2934,
Ochotona princeps	ENSOPRG00000011836	2 retrocopies	retro_opri_56, retro_opri_924,
Pongo abelii	ENSPPYG00000011041	5 retrocopies	retro_pabe_3453, retro_pabe_3454, retro_pabe_3519, retro_pabe_3520, retro_pabe_692,
Pan troglodytes	ENSPTRG00000013529	12 retrocopies	retro_ptro_1010, retro_ptro_1686, retro_ptro_2390, retro_ptro_2828, retro_ptro_2887, retro_ptro_3125, retro_ptro_3201, retro_ptro_3225, retro_ptro_412, retro_ptro_453, retro_ptro_594, retro_ptro_965,
Pteropus vampyrus	ENSPVAG00000012662	1 retrocopy	retro_pvam_157,
Sarcophilus harrisii	ENSSHAG00000011241	1 retrocopy	retro_shar_483,
Sus scrofa	ENSSSCG00000007381	1 retrocopy	retro_sscr_506,
Ictidomys tridecemlineatus	ENSSTOG00000003733	1 retrocopy	retro_itri_1214,
Tupaia belangeri	ENSTBEG00000002806	47 retrocopies	retro_tbel_1038, retro_tbel_1272, retro_tbel_1460, retro_tbel_1472, retro_tbel_1572, retro_tbel_1653, retro_tbel_1664, retro_tbel_2127, retro_tbel_2128, retro_tbel_2229, retro_tbel_2246, retro_tbel_228, retro_tbel_2371, retro_tbel_2373, retro_tbel_2379, retro_tbel_2397, retro_tbel_2512, retro_tbel_2536, retro_tbel_2540, retro_tbel_2542, retro_tbel_2583, retro_tbel_2584, retro_tbel_2615, retro_tbel_2617, retro_tbel_3502, retro_tbel_3554, retro_tbel_3604, retro_tbel_3642, retro_tbel_3743, retro_tbel_390, retro_tbel_3989, retro_tbel_3993, retro_tbel_40, retro_tbel_4101, retro_tbel_4121, retro_tbel_4338, retro_tbel_4447, retro_tbel_4456, retro_tbel_4459, retro_tbel_4510, retro_tbel_4514, retro_tbel_4604, retro_tbel_4664, retro_tbel_4690, retro_tbel_5, retro_tbel_705, retro_tbel_854,
Tarsius syrichta	ENSTSYG00000006537	4 retrocopies	retro_tsyr_1065, retro_tsyr_1473, retro_tsyr_1637, retro_tsyr_2084,
Tursiops truncatus	ENSTTRG00000007615	1 retrocopy	retro_ttru_762,
Vicugna pacos	ENSVPAG00000005023	3 retrocopies	retro_vpac_396, retro_vpac_516, retro_vpac_9,