RetrogeneDB ID: retro_ggor_690

Retrocopy location

• Organism: Gorilla (Gorilla gorilla)
• Coordinates: 11:4173913..4175023(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: EZR
• Ensembl ID: ENSGGOG00000013301
• Aliases: None
• Description: None

Sequence

>retro_ggor_690
ACTGAATTGTGCCTAGGTGTTGATGCTTTGGGTCTGAATATTTATGAGCATGATGACAAGTTAACACCTAAAACTGGTTT
TCCGTGGAGTGAAATCAGAAATGTTTCATTTAATGACAAAAAATTTGTTATAAAGCCAATCAACAAAAAGACACCTGATT
TTGGTTTTTATGCCCCTCACCTGAGAGTCAATAAGCAGATTTTGGCCTTATGTATGGGAAACCACGAACTATACATGCGA
AGAAGGAAGCCTGATACTATTGAAGTATGACAGATGAGGGCTCAGGCTAGGAAGGAGAAACATCAGAAGCAGTTGGAGAG
GGCACAATTAGAGAATAAAAAGAAGAAAAGAGAAATAGCAGAAAAGGAAAGAATAGAATGTGAAAAGGAAGAGCTAATGG
AACGTCTAAAACAAATAGAAGAACAGACGATTAAAGCCCAGAAATAACTAGAAGAACGGACGCAAAAAGCTCTAGAACTG
GATCAAGAATGAAAACGAGCAAAAGAAGCAGCAGAGTGGCTTGAAAAGGAGCGTCGAGCTGCTGAAGAGGCGAAGTCTGC
CATAGCAAAACAAGCTGCCGACCAGAAGAAGAATCAGGAGCAGCTAGCAGCAAAACTTGCTCAATTCACTGCCAAGATTG
TACTTCTAGAAGAAGCCAAGAAGAAAAAGGAAGAGGAAGCTACTGAGTGGCAACACAAAGGTTTTGCAGCCCAGAAGACT
TGGAAAAGACCAAAGAAGAGTTAAAAACTGTGATGTCTGCCCCACCCCCGACCTCCACCACCACCACCACCAGTCATTCC
TTCGACAGAAAATGAACGTGATGAACATGATGAGATTAGTGCTGAGGCTCGTGCTGAATTATCAAATGAAGGGGTAATGA
ACCATAGAAGCAAAGAAGAACATGTAACATAAACACAGAAAAACGAGCGTGTTAAGAAGCAACTTCAGGCCTTAAGTTCA
GAATTAGCCCAAGCCAGAGATGAAACCAAGAAAACACAAAAGGATGTTCTTCAGGCTAAGAATGTTGAAACAGGCCATGG
TAAGTACAAGACTCTGTGACCGATTCGACAAGGCAACACAAAGCAGCGTACCAGTGAGTTTGAAGCAATG

Alignment

ORF - retro_ggor_690 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 57.82 %
• Parental protein coverage: 63.71 %
• Number of stop codons detected: 5
• Number of frameshifts detected: 2

Retrocopy - Parental Gene Alignment:

Parental  TDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQL
          T.L.LGVDALGLNIYE.DDKLTPK.GFPWSEIRN.SFNDKKFVIKPI.KK.PDF.FYAP.LR.NK.IL.L
Retrocopy TELCLGVDALGLNIYEHDDKLTPKTGFPWSEIRNVSFNDKKFVIKPINKKTPDFGFYAPHLRVNKQILAL

Parental  CMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERRQQLETEKKRRETVEREKEQMMREKEELMLRLQ
          CMGNHELYMRRRKPDTIEV.QM.AQAR.EKHQKQLER.Q.....................E..E......
Retrocopy CMGNHELYMRRRKPDTIEV*QMRAQARKEKHQKQLERAQXXXXXXXXXXXXXXXXXXXXEELMERLKQIE

Parental  DYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELA
          ....K..K...E.......AL.L..E.KRA.E.AE.LE..R.AA..AK.....QA.DQ.K.QEQLAA.LA
Retrocopy EQTIKAQK*LEERTQK---ALELDQE*KRAKEAAEWLEKERRAAEEAKSAIAKQAADQKKNQEQLAAKLA

Parental  EYTAKIALLEEARRRKEDEVEEWQHRAKEAQ-DDLVKTKEELHLVMTAPPP-PPPPVYEPVSYHVQESLQ
          ..TAKI.LLEEA...KE.E..EWQH....AQ..DL.KTKEEL..VM.APPP.PPPP...P......E...
Retrocopy QFTAKIVLLEEAKKKKEEEATEWQHKGFAAQ<EDLEKTKEELKTVMSAPPP>PPPP--PPPVIPSTENER

Parental  DEGTEPTGYS-AELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMR
          DE..E......AELS.EG....R..E...T...KNERV..QL..LSSEL.QARDE.K.T..D.....N..
Retrocopy DEHDEISAEARAELSNEGVMNHRSKEEHVT*TQKNERVKKQLQALSSELAQARDETKKTQKDVLQAKNVE

Parental  QGRDKYKTLRQIRQGNTKQRIDEFEAL
          .G..KYKTL..IRQGNTKQR..EFEA.
Retrocopy TGHGKYKTL*PIRQGNTKQRTSEFEAM

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	71.12 RPM
SRP007412_cerebellum	0.04 RPM	10.09 RPM
SRP007412_heart	0.00 RPM	58.38 RPM
SRP007412_kidney	0.00 RPM	384.72 RPM
SRP007412_liver	0.00 RPM	28.99 RPM
SRP007412_testis	0.00 RPM	168.04 RPM

ChIP-Seq

Gorilla gorilla was not studied using ChIP-Seq data.

EST

Gorilla gorilla was not studied using EST data.

TSS

Gorilla gorilla was not studied using FANTOM5 data.

Lab

retro_ggor_690 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_ggor_690 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 5 parental genes, and 7 retrocopies.

Species	Parental gene accession	Retrocopies number
Gorilla gorilla	ENSGGOG00000001823	1 retrocopy	retro_ggor_1359,
Gorilla gorilla	ENSGGOG00000013301	1 retrocopy	retro_ggor_690 ,
Gorilla gorilla	ENSGGOG00000027218	1 retrocopy	retro_ggor_689,
Myotis lucifugus	ENSMLUG00000001931	3 retrocopies	retro_mluc_2037, retro_mluc_358, retro_mluc_469,
Monodelphis domestica	ENSMODG00000007642	1 retrocopy	retro_mdom_78,