RetrogeneDB ID: retro_pabe_1205

Retrocopy location

• Organism: Orangutan (Pongo abelii)
• Coordinates: 14:102792513..102792981(-)
• Located in intron of: None

Retrocopy information

• Ensembl ID: None
• Aliases: None
• Status: NOVEL

Parental gene information

• Parental gene symbol: AKTIP
• Ensembl ID: ENSPPYG00000007351
• Aliases: AKTIP, FTS
• Description: AKT-interacting protein [Source:UniProtKB/Swiss-Prot;Acc:Q5RE48]

Sequence

>retro_pabe_1205
CCGCAAAGCACTTTACCCAGCATGGAGGCTCCACCTCTTGCCACAGCAGCACAGACAGCTAATGGCATACAGGGTTCTAG
AAGACCGTTCTACCTGGAGGATCTTCTTGTGGCATCTACCTCCATCATGAAGCAGAAGTCATCTGGCACCTGTGTGCAGT
CATCTTATCGCTCTGCATTTGTGTAGGTTGGAAGAGTTTCATTCAGCATGGACTTTATCAAGACTGTGCATTTAGGCCTA
CAGCTCATATCCCTGATAACTATCTGGGTGGTGCCTGTCCACACCTGGTATTTGACGTTCCTGCCTTTCACACCCTCATT
AATTCCATCTCTGTGAACTGGATGTGCAGAGAGATTTGCAAAGTGGAGGTGGAACCATAATTGCACTTGGGAAGTACCCA
TCAGTACAAAGAAACATTTCTTCAAGATTGATGCAGCAAACCCCCTAAACCCAGAGGCTACAGTAGTG

Alignment

ORF - retro_pabe_1205 Open Reading Frame is not conserved.

Retrocopy - Parental Gene Alignment summary:

• Percent Identity: 52.17 %
• Parental protein coverage: 53.92 %
• Number of stop codons detected: 1
• Number of frameshifts detected: 3

Retrocopy - Parental Gene Alignment:

Parental  PKNALPITKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRSALMWFGVI-FI
          P...LP.......A.AAQ..NG...S..PFYLE..LL...T...KQK..G..VQ.SYRSA....G...FI
Retrocopy PQSTLPSMEAPPLATAAQTANGIQGSRRPFYLE-DLLVASTSIMKQKSSGTCVQSSYRSAFV*VGRV<FI

Parental  RHGLYQDGVFKFTVYIPDNYPDGDCPRLVFDIPVFHPLVDPTS-GELDVKR-AFAKWRRNHNHIWQVLMY
          .HGLYQD..F..T..IPDNY..G.CP.LVFD.P.FH.L....S..ELDV.R..FAKWR.NHN..W.V...
Retrocopy QHGLYQDCAFRPTAHIPDNYLGGACPHLVFDVPAFHTLINSIS<CELDVQR<RFAKWRWNHNCTWEVPIS

Parental  ARRVFYKIDTASPLNPEAAVL
          ....F.KID.A.PLNPEA.V.
Retrocopy TKKHFFKIDAANPLNPEATVV

Legend:

• *: Stop codon
• >: Forward frameshift by one nucleotide
• <: Reverse frameshift by one nucleotide

Expression

RNA-Seq

Expression validation based on RNA-Seq data:

Library	Retrocopy expression	Parental gene expression
SRP007412_brain_prefrontal_cortex	0.00 RPM	49.10 RPM
SRP007412_cerebellum	0.00 RPM	20.31 RPM
SRP007412_heart	0.00 RPM	16.41 RPM
SRP007412_kidney	0.00 RPM	14.39 RPM
SRP007412_liver	0.00 RPM	6.06 RPM

ChIP-Seq

Pongo abelii was not studied using ChIP-Seq data.

EST

No EST(s) were mapped for retro_pabe_1205 retrocopy.

TSS

Pongo abelii was not studied using FANTOM5 data.

Lab

retro_pabe_1205 was not experimentally validated.

Homology

Retrocopy orthology:

Retrocopy retro_pabe_1205 has 0 orthologous retrocopies within eutheria group .

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Parental genes homology:

Parental genes homology involve 20 parental genes, and 32 retrocopies.

Species	Parental gene accession	Retrocopies number
Ailuropoda melanoleuca	ENSAMEG00000016345	1 retrocopy	retro_amel_392,
Canis familiaris	ENSCAFG00000009500	1 retrocopy	retro_cfam_1826,
Choloepus hoffmanni	ENSCHOG00000013690	2 retrocopies	retro_chof_2533, retro_chof_629,
Callithrix jacchus	ENSCJAG00000001498	1 retrocopy	retro_cjac_2895,
Cavia porcellus	ENSCPOG00000006523	1 retrocopy	retro_cpor_622,
Dasypus novemcinctus	ENSDNOG00000004906	4 retrocopies	retro_dnov_1376, retro_dnov_1776, retro_dnov_2080, retro_dnov_756,
Equus caballus	ENSECAG00000020381	1 retrocopy	retro_ecab_504,
Homo sapiens	ENSG00000166971	2 retrocopies	retro_hsap_1458, retro_hsap_3152,
Gorilla gorilla	ENSGGOG00000014821	1 retrocopy	retro_ggor_1122,
Microcebus murinus	ENSMICG00000010810	3 retrocopies	retro_mmur_124, retro_mmur_333, retro_mmur_985,
Microcebus murinus	ENSMICG00000016793	1 retrocopy	retro_mmur_1191,
Monodelphis domestica	ENSMODG00000025788	1 retrocopy	retro_mdom_1881,
Nomascus leucogenys	ENSNLEG00000001106	1 retrocopy	retro_nleu_2660,
Otolemur garnettii	ENSOGAG00000014495	1 retrocopy	retro_ogar_365,
Oryzias latipes	ENSORLG00000013747	1 retrocopy	retro_olat_30,
Pongo abelii	ENSPPYG00000007351	2 retrocopies	retro_pabe_1204, retro_pabe_1205 ,
Pan troglodytes	ENSPTRG00000008116	1 retrocopy	retro_ptro_2282,
Rattus norvegicus	ENSRNOG00000011956	1 retrocopy	retro_rnor_1611,
Tupaia belangeri	ENSTBEG00000017105	5 retrocopies	retro_tbel_1063, retro_tbel_2864, retro_tbel_3350, retro_tbel_4130, retro_tbel_853,
Tursiops truncatus	ENSTTRG00000012705	1 retrocopy	retro_ttru_348,